哈佛大学医学院高翔(Xiang

哈佛大学医学院高翔(Xiang 哈佛大学医学院高翔(Xiang Gao)博士简历 Harvard Medical School/Harvard School of Dental Medicine Format for the Curriculum Vitae Date Prepared: Oct 2009 Name: Xiang Gao Office Address: 665 Huntington Avenue, Bldg. 2, Room 310, Boston, MA 02115 Home Address: 3920 Mystic Valley Parkway, #607E, Medford, MA 02155 Work Phone: 617-432-5080 Work Email: xiang.gao@channing.harvard.edu Work FAX: 617-432-2435 Place of Birth: Shihezi, China Education 1994 MD Clinical Medicine Shanghai Second Medical University, Shanghai, China 2001 M.S. Epidemiology & Biostatistics Chinese Academy of Medical Science & Peking Union Medical College, Beijing, China 2005 Ph.D. Nutritional Epidemiology Tufts School of Nutrition (Katherine L. Tucker) and Food Policy, Boston, MA Postdoctoral Training 10/05-06/07 Research Fellow Neuro-epidemiology Department of Nutrition (Alberto Ascherio) Harvard School of Public Health, Boston, MA 07/07-12/08 Research Associate Neuro-epidemiology Department of Nutrition (Alberto Ascherio) Harvard School of Public Health Faculty Academic Appointments 1 09/97-08/98 Instructor Preventive Medicine Department of Preventive Medicine, Shihezi University School of Medicine, Xinjiang, P.R.China 01/09- Instructor Medicine Channing Laboratory, Department of Medicine, Harvard Medical School Appointments at Hospitals/Affiliated Institutions 01/09- Associate Channing Laboratory Brigham and Women's Epidemiologist Hospital 01/09- Research Scientist Department of Nutrition Harvard School of Public Health Other Professional Positions 1994-97 Teaching Assistant in Nutrition (Full time) Shihezi University, Xinjiang, China 1998-01 Research Assistant in Epidemiology Chinese Academy of Medical Science 2001-05 Research Assistant in Nutrition Jean Mayor USDA Human Nutrition Research Center on Aging at Tufts University Professional Societies 2002- American Society for Nutrition Member 2004-05 Society for Epidemiologic Research Member 2004-05 New York Academy of Science Member 2008- Parkinson Study Group 2008-11 Member, Mentoring Committee The Parkinson Study Group is a non-profit, cooperative group of Parkinson's disease experts from more than 120 medical centers in the United States and Canada who are dedicated to improving treatment for persons affected by Parkinson's disease, including more than 400 active investigators, coordinators and scientists. The Mentoring Committee includes 11 members and the main mission is to be responsible for soliciting, reviewing, and selecting candidates to receive the Mentored Clinical Research Fellowship Awards, serve as a resource for individuals who need assistance in formulating and developing protocols to the point where they are ready for review, and to develop and organize innovative programs to promote interest in Parkinson’s disease research, and facilitate the development of mentorship relationships. 2 Grant Review Activities 2008- Mentored Clinical Research Award Parkinson Study Group reviewer 2008 Permanent Member 2009 Permanent Member 2009 Cooperative Studies Program reviewer U.S. Department of Veterans Affairs 2009 Ad hoc reviewer Editorial Activities , Ad hoc Reviewer 1. The Journal of American Medical Association 2. Annals of Internal Medicine (top 10% of reviewers in 2007) 3. Archives of Neurology 4. American Journal of Epidemiology 5. American Journal of Clinical Nutrition 6. Journal of Nutrition 7. Journal of the American Dietetic Association 8. Nutrition & Metabolism 9. Cancer Epidemiology Biomarkers & Prevention 10. American Journal of Preventive Medicine 11. Journal of Immigrant & Minority Health 12. North American Journal of Medicine & Science 13. Clinical Nutrition 14. Neuroepidemiology 15. Asia Pacific Journal of Clinical Nutrition 16. Current Medical Chemistry 17. Parkinson’s Disease 18. Journal of the Neurological Sciences 19. Journal of Alzheimer Other Editorial Roles 2008- Member of Editorial Board Nutrition and Metabolic Insights Honors and Prizes 1997 Excellent Paper Award Shihezi Association of Science Research (second prize) 1997 Excellent Paper Award Hubei International Conference of Research (second prize) Maternal & Child Health 1997 Teaching Achievement Shihezi University, P.R.China Teaching Award (second prize) 1997 Outstanding Faculty Shihezi University, P.R.China Teaching 3 1999 Outstanding Graduate Chinese Academy of Medical Student Science & Peking Union Medical College, P.R.China 2003 Graduate Student 2003 Experimental Biology Research Award Annual Meeting, Nutritional Epidemiology Research Interest Section, American Society for Nutrition 2004 Fellowship Award Vitamin E and Health Conference, Research New York Academy of Science th2005 Travel Award 18 International Congress of Research Nutrition, American Society for Nutrition 2005 Graduate Student 2005 Experimental Biology Research Award Annual Meeting, Nutritional Epidemiology Research Interest Section, American Society for Nutrition 2006 Irwin H. Rosenberg Jean Mayor USDA Human Research Pre-doctoral Award Nutrition Research Center on Aging at Tufts University th2008 Travel Award 12 International Congress of Research Parkinson's Disease and Movement Disorders Report of Funded and Unfunded Projects Funding Information Past 2004-05 How to meet recommended adequate intake (AI) of calcium from food alone for children aged 9-18 y who avoid drinking milk: an analysis by linear programming Tufts University Center for Children & University College of Citizenship and Public Service, Applied Research Award 4 Role: PI The major goal of this project is to develop a novel dietary pattern methodology, linear programming, to examine whether a dairy-free diet can provide adequate intake of calcium for children 2007-08 Prospective study of diet quality, dietary urate index and survival of Parkinson’s disease patients Parkinson Study Group, Mentored Clinical Research Award Role: PI The major goal of this project is to examine whether a healthier dietary pattern and a higher dietary urate index are positively associated with survival of Parkinson’s disease patients Current 2009-12 Prospective Study of Restless Leg Syndrome NINDS R01 NS062879-01A1 Role: PI To prospectively investigate risk factors (obesity, blood donation, and genetic components) and clinical consequences of restless legs syndrome among ~100,000 men and women. 2009-14 Urate as a predictor of Parkinson’s disease risk and progression (PI: Ascherio) NINDS R01 NS061858-01A1 Role: Project Director To examine whether blood levels of urate (uric acid) and genetic mutations that affects the formation of urate or its excretion predict the risk of developing Parkinson's disease or the progression of symptoms among patients with Parkinson's disease. Current Unfunded Projects 2009 PI / Restless Legs Syndrome in Older Puerto Ricans We have submitted a NIH R21 grant to investigate whether obesity, homocysteine, and melatonin status are associated with risk of restless legs syndrome in a representative sample of older Puerto Ricans living in MA. The grant received a score of 67 (51 percentile). This application will be reviewed in February, 2010. 2009 PI / Oxidative Stress Biomarkers and Cognitive Decline in Older Puerto Ricans We have submitted a NIH R01 grant to prospectively investigate several oxidative stress biomarkers and cognitive decline in a representative sample of older Puerto Ricans living in MA (n=1,400). This application will be resubmitted in Mar, 2010. 2009 CI / Risk factors and biomarkers of Parkinson’s disease in the Women’s Health Initiative We have submitted a NIH R01 grant to prospectively investigate risk factors and biomakers of Parkinson’s disease in women. This application will be reviewed in 5 February, 2010. Report of Local Teaching and Training Teaching of Students in Courses Shihezi University School of Medicine 1995-97 Preventive Medicine (in Chinese) Shihezi University School of Medicine, rd3 year medical students China ~ 30 hours per year 1996-98 Clinical Nutrition (in Chinese) Shihezi University School of Medicine, th4 year medical students China ~ 60 hours per year Harvard School of Public Health 2009 Epidemiology of Neurologic Diseases, Harvard School of Public Health Harvard School of Public Health Three hour lecture Graduate Students Local Invited Presentations 2006 Dietary urate index and Parkinson’s disease / Monday Nutrition Seminar Department of Nutrition, Harvard School of Public Health Report of Regional, National and International Invited Teaching and Presentations Invited Presentations and Courses Regional 2005 Nutritional Epidemiology /Three hour lecture Tufts University School of Nutrition and Food Science, Boston 2006 Nutritional Epidemiology / Three hour lecture Tufts University School of Nutrition and Food Science, Boston 2006 The 2005 USDA Food Guide Pyramid is associated with more adequate nutrient Intakes within energy constraints than the 1992 Pyramid / HNRCA Seminar 6 Jean Mayor USDA Human Nutrition Research Center on Aging (HNRCA) at Tufts University, Boston National 2006 Dietary pattern, food policy and health / Seminar Department of Nutrition, The University of North Carolina at Chapel Hill, NC 2006 Dietary urate index and Parkinson’s disease / Oral presentation (abstract) th59 Annual Meeting of the American Academy of Neurology, Boston 2008 Change of diet quality among Parkinson’s disease patients / Plenary talk (abstract) 2008 Parkinson Study Group annual meeting, San Diego, CA International 2004 Dietary pattern and health / Seminar Institute of Basic Medical Science, Chinese Academy of Medical Science, Beijing, China 2005 Meeting adequate intake for dietary calcium without dairy foods in adolescents, aged 9-18 / Oral presentation (abstract) Society for Epidemiologic Research annual meeting, Toronto, Canada 2007 Dietary pattern, disease, and US food policy / Plenary talk Epidemiology Branch Annual Meeting, Chinese Academy of Medical Science, Beijing, China 2007 Diet and health / Seminar Peking Union Hospital, Beijing, China 2007 Diet and health / Seminar Shihezi University School of Medicine, Xinjiang, China 2009 Morbidity, co-morbidity and mortality in restless legs syndrome and periodic limb movements in sleep / Symposium Speaker rdth3 International Congress of Sleep Medicine and 12 Brazilian Congress on Sleep Medicine, Sao Paulo, Brazil Report of Scholarship Publications Peer reviewed publications in print or other media 7 Research investigations Chinese Gao X, Xu F. Body mass index, lean body weight and body fat percentage among Uygur and 1. Kazak adolescents aged 15-16 y in Shihezi City (Chinese). Journal of Practical Nutrition, 1996;3 (3): 16. Gao X, Wang H, Zhang W. Comprehensive evaluation of sanitation quality of hotels in Shihezi 2. city (Chinese). Journal of Shihezi Medical College, 1996;18 (1): 20-22. Gao X, Tang M. Evaluation of dietary intake among medical students (Chinese). Journal of 3. Shihezi Medical College, 1996;18 (2): 94-96. Tang M, Gao X. Skinfold thickness among Uygur and Kazak high school students (Chinese). 4. Journal of Shihezi Medical College, 1996;18 (2): 92-93. Wang L, Yang L, Gao X. Cigarette use and risk factors among medical students (Chinese). 5. Chinese Primary Health Care, 1997;11 (suppl): 52s-55s. Wang L, Gao X. An intervention study to change KABP of smoking among medical students 6. (Chinese). Chinese Primary Health Care, 1997;11 (suppl): 27s-29s. Yang L, Gao X. Validation of body mass indices among four ethnic groups of adolescent 7. (Chinese). Chinese Journal of School Health. 1999;20(1-B): 49-50. Gao X, Dong Z, Tang Y, Wu Z. Pooling of urine specimens for PCR method to detect of 8. Chlamydia trachomatis infection among university students (Chinese). Chinese Preventive Medicine, 2000;1(1): 32-36. Qin J, Guo S, Tang J, Jin L, Gao X, Yang L, et al. Factors associated with hospital costs in 9. Xinjiang production and construction corps (Chinese). Chinese Journal of Biostatistics, 2001;18(4);249-53. English Zhang L, Gao X, Dong Z, Tan Y, Wu Z. Premarital sexual activities among students in a 10. university in Beijing, China. Sexually Transmitted Diseases. 2002;29(4):212-5. Gao X, Yao M, McCrory MA, Ma G, Li Y, Roberts SB, Tucker KL. Dietary pattern is 11. associated with homocysteine and B vitamin status in an urban Chinese population. J Nutr. 2003;133(11):3636-42. Gao X, Bermudez OI, Tucker KL. Plasma C-reactive protein and homocysteine concentrations 12. are related to frequent fruit and vegetable intake in Hispanic and non-Hispanic white elders. J Nutr. 2004;134(4):913-8. Gao, X, Wilde PE, Maras JE, Bermudez OI, and Tucker KL. The maximal amount of α-13. tocopherol intake from foods alone in U.S. adults (1994-96 CSFII): An analysis by linear 8 programming. Ann N Y Acad Sci. 2004;1031:385-6. Gao X, LaValley MP, Tucker KL. Prospective studies of diary product and calcium intakes and 14. prostate cancer risk: a meta-analysis. J Natl Cancer Inst. 2005;97(23): 1768-77. Gao X, Wilde PE, Lichtenstein AH, Bermudez OI, Tucker KL. The maximal amount of dietary 15. α-tocopherol intake in U.S. adults (NHANES 2001-2002). J Nutr. 2006;136(4):1021-6. Gao X, Wilde PE, Lichtenstein AH, Tucker KL. The 2005 USDA food guide pyramid is 16. associated with more adequate nutrient intakes within energy constraints than the 1992 pyramid. J Nutr. 2006;136(5): 1341-6. Gao X, Wilde PE, Lichtenstein AH, Tucker KL. Meeting adequate intake (AI) for dietary 17. calcium without dairy foods in adolescents, aged 9-18 y (NHANES 2001-2002). J Am Diet Assoc. 2006;106(11): 1759-65; Related editorial: Weaver CM. Back to basics: Have milk with meals. JADA 2006;106:1756. Gao X, Martin A, Lin H, Bermudez OI, Tucker KL. Plasma α-tocopherol status of Hispanic and 18. non-Hispanic white elders is inadequate and is associated with intake patterns. J Nutr. 2006;136(10):2574-9. Gao J, Shan G, Sun B, Thompson PJ, Gao X. Association between polymorphism of tumor 19. necrosis factor α-308 and asthma: a meta-analysis. Thorax. 2006; 61(6):466-71. Gao X, Nelson ME, Tucker KL. Television viewing is associated with metabolic syndrome in 20. Hispanic elders. Diabetes Care. 2007;30(3):694-700. Carrera PM, Gao X, Tucker KL. A study of dietary patterns in the Mexican-American 21. population and their association with obesity. J Am Diet Assoc. 2007;107(10):1735-42. Gao X, Lu Q, Qiao N, Choi HK, Gurhan G, Tucker KL, Ascherio A. Intake of added sugar and 22. sugar-sweetened beverage is associated with serum uric acid. Hypertension. 2007;50(2);306-12. Gao X, Chen H, Schwarzschild MA, Glasser DB, Logroscino G, Rimm EB, Ascherio A. 23. Erectile function and risk of Parkinson’s disease. Am J Epidemiol. 2007;166:1446-50. Gao X, Chen H, Fung TT, Logroscino G, Schwarzschild MA, Hu FB, Ascherio A. Prospective 24. study of dietary pattern and risk of Parkinson’s disease. Am J Clin Nutr. 2007; 86: 1486-94. Wang H, Chen H, Gao X, McGrath M, Deer D, De Vivo I, Schwarzschild MA, Ascherio A. 25. Telomere length and risk of Parkinson's disease. Mov Disord. 2008;30;23(2):302-5. Choi J, Ford E, Gao X, Choi HK. Sugar-sweetened soft drinks, diet soft drinks, and serum uric 26. acid level – the Third National Health and Nutrition Examination Survey. Arthritis Rheum. 2008;15;59(1):109-16. Gao X, Chen H, Schwarzschild MA, Logroscino G, Ascherio A. Perceived imbalance and risk 27. of Parkinson’s disease. Mov Disord. 2008;23(4):613-6. 9 Gao X, Chen H, Choi HK, Curhan G, Schwarzschild MA, Ascherio A. Diet, urate, and risk of 28. Parkinson’s disease. Am J Epidemiol. 2008;167(7):831-8. Henkin S, Brugge D, Bermudez OI, Gao X. A case-control study of BMI and asthma in Asian 29. children. Annals of Allergy, Asthma & Immunology. 2008;100:447-51. Gao J, Gao X, Li W, Zhu Y. Thompson PJ. Observational studies on the effect of dietary 30. antioxidants on asthma: a meta-analysis. Respirology. 2008; 13(4):528-36. Gao X, Curhan G, Forman J, Ascherio A, Choi HK. Vitamin C intake and serum uric acid 31. concentration in men. J Rheumatol. 2008; 35:1853-58. De Vera M, Rahman MM, Rankin J, Kopec J, Gao X, Choi HK. Gout and the risk of 32. Parkinson's disease: a cohort study. Arthritis Care & Research. 2008; 59(11):1549-54. Logroscino G, Gao X, Chen H, Al Wing, and Ascherio A. Dietary iron intake and risk of 33. Parkinson’s disease. Am J Epidemiol. 2008;168(12):1381-8 O’Reilly EJ, Chen H, Gardener H, Gao X, Schwarzschild MA, Ascherio A. Smoking and 34 Parkinson's disease: using parental smoking as a proxy to explore causality. Am J Epidemiol, 2009. 169(6):678-82 Gao X, Simon KC, Han J, Schwarzschild MA, Ascherio A. Genetic determinants of hair color 35. and Parkinson’s disease risk. Ann Neurol . 2009; 65(1):76-82. Choi HK, Gao X, Curhan G. Vitamin C intake and the risk of gout in men – a prospective 36. study. Arch Intern Med. 2009;169;502-7 Gao X, Scott T, Falcon LM, Wilde PE, Tucker KL. Food insecurity and cognitive function in 37. Puerto Rican adults. Am J Clin Nutr. 2009;89;1197-1203 Gao X, Schwarzschild MA, Wang H, Ascherio A. Obesity and restless legs syndrome in men 38. and women. Neurology. 2009;72;1255-61 Wu T, Gao X, Chen M, van Dam RM. Long-term effectiveness of diet plus exercise versus 39. diet-only interventions for weight loss: a meta-analysis. Obes Rev. 2009. 10(3):313-23 Simon KC, Chen H, Gao X, Schwarzschild MA, Ascherio A. Reproductive factors, 40. exogenous estrogen use and risk of Parkinson's disease. Mov Disord, 2009;24:1359-65 Gao X, Simon KC, Han J, Schwarzschild MA, Ascherio A. Family history of melanoma and 41. Parkinson’s disease risk. Neurology, 2009;73:1286-91 Henkin S , Tucker KL, Gao X, Qiao N, Brugge D. Association of depression, psycho-social 42. stress and acculturation with respiratory disease among Puerto Rican adults in Massachusetts. Journal of Immigrant and Minority Health, in press 10 Gao X, Schwarzschild MA, O’Reilly EJ, Wang H, Ascherio A. Restless legs syndrome and 43. erectile dysfunction. Sleep, in press Gao X, Sahni S. Obesity, Diet, and Risk of Restless Legs Syndrome. The European 44. Neurological Journal, in press Non-peer reviewed scientific or medical publications/materials in print or other media Letters to Editors Gao X, La Valley M, Tucker KL. Response to Severi. J Natl Cancer Inst. 2006;9(11):795 1. Gao X, Simon KC, Han J, Schwarzschild MA, Ascherio A. Reply to Hernández. Ann Neurol. 2. 2009. 17;65(6):759 Professional educational materials or reports, in print or other media NA Clinical Guidelines and Reports NA Thesis Gao X. Using methods of optimization Programming and Meta-analysis to Evaluate Current United States Nutrition Recommendations. Boston: Nutritional Epidemiology, Tufts University; 2005. Abstracts, Poster Presentations and Exhibits Presented at Professional Meetings Gao X, Weisskopf MG, Schwarzschild MA, Grodstein F, Ascherio A. Tea, coffee, and 1. cognitive function among incident PD patients (Abstract). 2008 American Academy of Neurology Annual Meeting, Chicago, IL. Gao X, Schwarzschild MA, Wang H, Ascherio A. Restless legs syndrome, erectile dysfunction, 2. thand Parkinson’s disease (Abstract). 12 International Congress of Parkinson's Disease and Movement Disorders (2008), Chicago, IL. 11