免疫球蛋白3nullImmunoglobulin:
Isotypes, Allotypes and IdiotypesImmunoglobulin:
Isotypes, Allotypes and IdiotypesImmunoglobulin IsotypesImmunoglobulin IsotypesDefinition - Antigenic determinants that characterize the classes and subclasses of heavy chains and types and s...
nullImmunoglobulin:
Isotypes, Allotypes and IdiotypesImmunoglobulin:
Isotypes, Allotypes and IdiotypesImmunoglobulin IsotypesImmunoglobulin IsotypesDefinition - Antigenic determinants that characterize the classes and subclasses of heavy chains and types and subtypes of light chainsnullHuman IgMantiserumReacts with
IgM, IgG, IgA, IgD, IgEReact with IgG, IgA, IgD and IgEAbsorbed antiserumReacts only with IgMRecognizes determinants
specific for heavy chains
(isotypes)Immunoglobulin Isotypes??????Immunoglobulin IsotypesImmunoglobulin IsotypesOccurrence
Importance
Ig levels
B cell tumors
Immunodeficiencies Definition LocationImmunoglobulin AllotypesImmunoglobulin Allotypes Definition - Antigenic determinants specified
by allelic forms of the Ig genes Location Occurrence Source of anti-allotypic AbsHuman Immunoglobulin AllotypesHuman Immunoglobulin Allotypes Nomenclature
G1m(3)
Km(1)Human Immunoglobulin AllotypesHuman Immunoglobulin Allotypes Genetics (alleles)
Co-dominant
autosomal genesKm(1)/Km(3) X Km(1)/Km(1)Km(1)/Km(1) and Km(1)/Km(3) Allelic exclusionHuman Immunoglobulin AllotypesHuman Immunoglobulin AllotypesGenetics (pseudoalleles)
Co-dominantG1m(17)G1m(1)214355-358Immunoglobulin AllotypesImmunoglobulin AllotypesDefinition
Location
Occurrence
Importance
Monitoring bone marrow grafts
Forensic medicine
Paternity testingImmunoglobulin IdiotypesImmunoglobulin IdiotypesDefinition - Unique antigenic determinants present on individual antibody molecules or on molecules of identical specificitynullDNP-BSAStrain A
MouseAnti-DNP Ab Purified
anti-DNP AbStrain A
Mouse Ab against
combining site of
anti-DNP Ab?? Immunoglobulin IdiotypesAntigenic determinants created by the HVR = IdiotypesImmunoglobulin IdiotypesImmunoglobulin IdiotypesDefinition
LocationIgG1 (kappa)
Person 1
anti-BIgG1 (kappa)
Person 1
anti-AImmunoglobulin IdiotypesImmunoglobulin IdiotypesDefinition
Location
Importance
V region marker
Regulation of immune responsesnullAgIdanti-Id+-anti-anti-Id+-Regulation by Id/anti-IdImmunoglobulin IdiotypesImmunoglobulin IdiotypesDefinition
Location
Importance
V region marker
Regulation of immune responses
VaccinesnullAnti-Idiotype VaccinesImmunoglobulin IdiotypesImmunoglobulin IdiotypesDefinition
Location
Importance
V region marker
Regulation of immune responses
Vaccines
Treatment of B cell tumors (T cell)
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