Cbz脱去方法

- Task History November 30, 2010 11:15 AM Explore reactions by substructure structure initiated Query Limiters 1 Non-participating functional group Acyclic Alkene Any source Number of Steps: 1 Explore complete Explore results Answer set 17 created with 76 reactions Kept 43 reaction answers from Answer set 17 Answer set 18 created with 43 reactions SciFinder® Page 1 1. Use of an endoxifen prodrug for treatment of breast cancer By Kushner, Peter et al From PCT Int. Appl., 2009120999, 01 Oct 2009 Copyright © 2010 American Chemical Society. All Rights Reserved. CASREACT contains reactions from CAS and from: ZIC/VINITI database (1974-1999) provided by InfoChem; INPI data prior to 1986; Biotransformations database compiled under the direction of Professor Dr. Klaus Kieslich; organic reactions, portions copyright 1996-2006 John Wiley & Sons, Ltd., John Wiley and Sons, Inc., Organic Reactions Inc., and Organic Synthesis Inc. Reproduced under license. All Rights Reserved. 5. SciFinder® Page 2 Preparation of pyridazine derivatives as factor XIa inhibitors By Corte, James R. et al From PCT Int. Appl., 2009114677, 17 Sep 2009 Copyright © 2010 American Chemical Society. All Rights Reserved. CASREACT contains reactions from CAS and from: ZIC/VINITI database (1974-1999) provided by InfoChem; INPI data prior to 1986; Biotransformations database compiled under the direction of Professor Dr. Klaus Kieslich; organic reactions, portions copyright 1996-2006 John Wiley & Sons, Ltd., John Wiley and Sons, Inc., Organic Reactions Inc., and Organic Synthesis Inc. Reproduced under license. All Rights Reserved. 6. SciFinder® Page 3 Total synthesis of cyclotheonamide C by use of an α-keto cyanophosphorane methodology for peptide assembly By Roche, Stephane P. et al From European Journal of Organic Chemistry, (30), 5067-5078, S5067/1-S5067/14; 2008 Copyright © 2010 American Chemical Society. All Rights Reserved. CASREACT contains reactions from CAS and from: ZIC/VINITI database (1974-1999) provided by InfoChem; INPI data prior to 1986; Biotransformations database compiled under the direction of Professor Dr. Klaus Kieslich; organic reactions, portions copyright 1996-2006 John Wiley & Sons, Ltd., John Wiley and Sons, Inc., Organic Reactions Inc., and Organic Synthesis Inc. Reproduced under license. All Rights Reserved. 7. SciFinder® Page 4 Passerini Reaction-Amine Deprotection-Acyl Migration Peptide Assembly: Efficient Formal Synthesis of Cyclotheonamide C By Faure, Sophie et al From Organic Letters, 11(5), 1167-1170; 2009 Copyright © 2010 American Chemical Society. All Rights Reserved. CASREACT contains reactions from CAS and from: ZIC/VINITI database (1974-1999) provided by InfoChem; INPI data prior to 1986; Biotransformations database compiled under the direction of Professor Dr. Klaus Kieslich; organic reactions, portions copyright 1996-2006 John Wiley & Sons, Ltd., John Wiley and Sons, Inc., Organic Reactions Inc., and Organic Synthesis Inc. Reproduced under license. All Rights Reserved. 8. One-pot tandem decarboxylative allylation-Heck cyclization of allyl diphenylglycinate imines: rapid access to polyfunctionalized 1-aminoindanes By Fields, Wendy H. et al SciFinder® Page 5 From Organic Letters, 10(22), 5131-5134; 2008 Copyright © 2010 American Chemical Society. All Rights Reserved. CASREACT contains reactions from CAS and from: ZIC/VINITI database (1974-1999) provided by InfoChem; INPI data prior to 1986; Biotransformations database compiled under the direction of Professor Dr. Klaus Kieslich; organic reactions, portions copyright 1996-2006 John Wiley & Sons, Ltd., John Wiley and Sons, Inc., Organic Reactions Inc., and Organic Synthesis Inc. Reproduced under license. All Rights Reserved. 9. Total synthesis of cyclotheonamide C using a tandem backbone-extension-coupling methodology By Roche, Stephane P. et al From Angewandte Chemie, International Edition, 47(36), 6840-6842; 2008 Copyright © 2010 American Chemical Society. All Rights Reserved. CASREACT contains reactions from CAS and from: ZIC/VINITI database (1974-1999) provided by InfoChem; INPI data prior to 1986; Biotransformations database compiled under the direction of Professor Dr. Klaus Kieslich; organic reactions, portions copyright 1996-2006 John Wiley & Sons, Ltd., John Wiley and Sons, Inc., Organic Reactions Inc., and Organic Synthesis Inc. Reproduced under license. All Rights Reserved. 10. SciFinder® Page 6 Phenylimidazole Derivatives of 4-Pyridone as Dual Inhibitors of Bacterial Enoyl-Acyl Carrier Protein Reductases FabI and FabK By Kitagawa, Hideo et al From Journal of Medicinal Chemistry, 50(19), 4710-4720; 2007 Copyright © 2010 American Chemical Society. All Rights Reserved. CASREACT contains reactions from CAS and from: ZIC/VINITI database (1974-1999) provided by InfoChem; INPI data prior to 1986; Biotransformations database compiled under the direction of Professor Dr. Klaus Kieslich; organic reactions, portions copyright 1996-2006 John Wiley & Sons, Ltd., John Wiley and Sons, Inc., Organic Reactions Inc., and Organic Synthesis Inc. Reproduced under license. All Rights Reserved. 11. SciFinder® Page 7 Preparation of nucleoside analogs as inhibitors of DNA methyltransferase isoforms DNMT1 and DNMT3b2 By Wahhab, Amal et al From PCT Int. Appl., 2006078752, 27 Jul 2006 Copyright © 2010 American Chemical Society. All Rights Reserved. CASREACT contains reactions from CAS and from: ZIC/VINITI database (1974-1999) provided by InfoChem; INPI data prior to 1986; Biotransformations database compiled under the direction of Professor Dr. Klaus Kieslich; organic reactions, portions copyright 1996-2006 John Wiley & Sons, Ltd., John Wiley and Sons, Inc., Organic Reactions Inc., and Organic Synthesis Inc. Reproduced under license. All Rights Reserved. 12. SciFinder® Page 8 Preparation of stilbene amino acid derivatives for inhibiting cancer cell growth and microbial growth By Pettit, George R. and Anderson, Collin R. From PCT Int. Appl., 2006124511, 23 Nov 2006 Copyright © 2010 American Chemical Society. All Rights Reserved. CASREACT contains reactions from CAS and from: ZIC/VINITI database (1974-1999) provided by InfoChem; INPI data prior to 1986; Biotransformations database compiled under the direction of Professor Dr. Klaus Kieslich; organic reactions, portions copyright 1996-2006 John Wiley & Sons, Ltd., John Wiley and Sons, Inc., Organic Reactions Inc., and Organic Synthesis Inc. Reproduced under license. All Rights Reserved. 13. SciFinder® Page 9 Regioselective and Diastereoselective Amination of Polybenzyl Ethers Using Chlorosulfonyl Isocyanate: Total Syntheses of 1, 4-Dideoxy-1,4-imino-D-arabinitol and (-)-Lentiginosine By Kim, In Su et al From Organic Letters, 8(18), 4101-4104; 2006 Copyright © 2010 American Chemical Society. All Rights Reserved. CASREACT contains reactions from CAS and from: ZIC/VINITI database (1974-1999) provided by InfoChem; INPI data prior to 1986; Biotransformations database compiled under the direction of Professor Dr. Klaus Kieslich; organic reactions, portions copyright 1996-2006 John Wiley & Sons, Ltd., John Wiley and Sons, Inc., Organic Reactions Inc., and Organic Synthesis Inc. Reproduced under license. All Rights Reserved. 14. SciFinder® Page 10 The synthesis of tethered ligand dimers for PPARγ-RXR protein heterodimers By Mohler, Debra L. and Shen, Gang From Organic & Biomolecular Chemistry, 4(11), 2082-2087; 2006 Copyright © 2010 American Chemical Society. All Rights Reserved. CASREACT contains reactions from CAS and from: ZIC/VINITI database (1974-1999) provided by InfoChem; INPI data prior to 1986; Biotransformations database compiled under the direction of Professor Dr. Klaus Kieslich; organic reactions, portions copyright 1996-2006 John Wiley & Sons, Ltd., John Wiley and Sons, Inc., Organic Reactions Inc., and Organic Synthesis Inc. Reproduced under license. All Rights Reserved. 15. SciFinder® Page 11 Synthetic Studies on (+)-Ophiobolin A: Asymmetric Synthesis of the Spirocyclic CD-Ring Moiety By Noguchi, Naoyoshi and Nakada, Masahisa From Organic Letters, 8(10), 2039-2042; 2006 Copyright © 2010 American Chemical Society. All Rights Reserved. CASREACT contains reactions from CAS and from: ZIC/VINITI database (1974-1999) provided by InfoChem; INPI data prior to 1986; Biotransformations database compiled under the direction of Professor Dr. Klaus Kieslich; organic reactions, portions copyright 1996-2006 John Wiley & Sons, Ltd., John Wiley and Sons, Inc., Organic Reactions Inc., and Organic Synthesis Inc. Reproduced under license. All Rights Reserved. 16. SciFinder® Page 12 Antineoplastic Agents. 515. Synthesis of Human Cancer Cell Growth Inhibitors Derived from 3,4-Methylenedioxy-5,4'- dimethoxy-3'-amino-Z-stilbene By Pettit, George R. et al From Journal of Natural Products, 68(8), 1191-1197; 2005 Copyright © 2010 American Chemical Society. All Rights Reserved. CASREACT contains reactions from CAS and from: ZIC/VINITI database (1974-1999) provided by InfoChem; INPI data prior to 1986; Biotransformations database compiled under the direction of Professor Dr. Klaus Kieslich; organic reactions, portions copyright 1996-2006 John Wiley & Sons, Ltd., John Wiley and Sons, Inc., Organic Reactions Inc., and Organic Synthesis Inc. Reproduced under license. All Rights Reserved. 17. SciFinder® Page 13 Synthesis of oligodeoxynucleotides containing a single diastereoisomer of α-(N2-2'-deoxyguanosinyl)-N-desmethyltamoxifen By Santosh Laxmi, Y. R. et al From Bioorganic & Medicinal Chemistry Letters, 14(15), 4051-4054; 2004 Copyright © 2010 American Chemical Society. All Rights Reserved. CASREACT contains reactions from CAS and from: ZIC/VINITI database (1974-1999) provided by InfoChem; INPI data prior to 1986; Biotransformations database compiled under the direction of Professor Dr. Klaus Kieslich; organic reactions, portions copyright 1996-2006 John Wiley & Sons, Ltd., John Wiley and Sons, Inc., Organic Reactions Inc., and Organic Synthesis Inc. Reproduced under license. All Rights Reserved. 19. SciFinder® Page 14 Synthesis of tripeptide inhibitors of peptidylglycine α-amidating monooxygenase (PAM) containing D- and L-styrylglycine By Andrews, Mark D. et al From Tetrahedron, 53(25), 8295-8306; 1997 Copyright © 2010 American Chemical Society. All Rights Reserved. CASREACT contains reactions from CAS and from: ZIC/VINITI database (1974-1999) provided by InfoChem; INPI data prior to 1986; Biotransformations database compiled under the direction of Professor Dr. Klaus Kieslich; organic reactions, portions copyright 1996-2006 John Wiley & Sons, Ltd., John Wiley and Sons, Inc., Organic Reactions Inc., and Organic Synthesis Inc. Reproduced under license. All Rights Reserved. 20. SciFinder® Page 15 Total synthesis of WS9326A, a potent tachykinin antagonist from Streptomyces violaceoniger By Shigematsu, Nobuharu et al From Chemical & Pharmaceutical Bulletin, 45(2), 236-242; 1997 Copyright © 2010 American Chemical Society. All Rights Reserved. CASREACT contains reactions from CAS and from: ZIC/VINITI database (1974-1999) provided by InfoChem; INPI data prior to 1986; Biotransformations database compiled under the direction of Professor Dr. Klaus Kieslich; organic reactions, portions copyright 1996-2006 John Wiley & Sons, Ltd., John Wiley and Sons, Inc., Organic Reactions Inc., and Organic Synthesis Inc. Reproduced under license. All Rights Reserved. 22. SciFinder® Page 16 Synthesis of dehydrophenylalanine-containing analogs of the 6-11 fragment of substance P additionally modified in position 9 By Wasiak, Tadeusz et al From Polish Journal of Chemistry, 60(4-6), 477-83; 1986 Copyright © 2010 American Chemical Society. All Rights Reserved. CASREACT contains reactions from CAS and from: ZIC/VINITI database (1974-1999) provided by InfoChem; INPI data prior to 1986; Biotransformations database compiled under the direction of Professor Dr. Klaus Kieslich; organic reactions, portions copyright 1996-2006 John Wiley & Sons, Ltd., John Wiley and Sons, Inc., Organic Reactions Inc., and Organic Synthesis Inc. Reproduced under license. All Rights Reserved. 28. SciFinder® Page 17 Dehydro-dermorphins. II. Synthesis and biological activity of unsaturated dermorphin hexa and heptapeptides By Salvadori, Severo et al From International Journal of Peptide & Protein Research, 28(3), 262-73; 1986 Copyright © 2010 American Chemical Society. All Rights Reserved. CASREACT contains reactions from CAS and from: ZIC/VINITI database (1974-1999) provided by InfoChem; INPI data prior to 1986; Biotransformations database compiled under the direction of Professor Dr. Klaus Kieslich; organic reactions, portions copyright 1996-2006 John Wiley & Sons, Ltd., John Wiley and Sons, Inc., Organic Reactions Inc., and Organic Synthesis Inc. Reproduced under license. All Rights Reserved. 31. SciFinder® Page 18 Dehydro-dermorphins. I. Influence of the stereo-orientation of aromatic groups in dermorphin-(1-5)-peptides to opioid activity By Salvadori, Severo et al From International Journal of Peptide & Protein Research, 28(3), 254-61; 1986 Copyright © 2010 American Chemical Society. All Rights Reserved. CASREACT contains reactions from CAS and from: ZIC/VINITI database (1974-1999) provided by InfoChem; INPI data prior to 1986; Biotransformations database compiled under the direction of Professor Dr. Klaus Kieslich; organic reactions, portions copyright 1996-2006 John Wiley & Sons, Ltd., John Wiley and Sons, Inc., Organic Reactions Inc., and Organic Synthesis Inc. Reproduced under license. All Rights Reserved. 32. Synthesis of a protected monodehydro Leu-enkephalin and its hydrogenation catalyzed by chiral rhodium complexes SciFinder® Page 19 By Nuzillard, J. M. et al From Tetrahedron Letters, 27(26), 2993-6; 1986 Copyright © 2010 American Chemical Society. All Rights Reserved. CASREACT contains reactions from CAS and from: ZIC/VINITI database (1974-1999) provided by InfoChem; INPI data prior to 1986; Biotransformations database compiled under the direction of Professor Dr. Klaus Kieslich; organic reactions, portions copyright 1996-2006 John Wiley & Sons, Ltd., John Wiley and Sons, Inc., Organic Reactions Inc., and Organic Synthesis Inc. Reproduced under license. All Rights Reserved. 43. Synthesis of peptides with α,β-dehydroamino acids, III. Debenzyloxycarbonylation and detrifluoroacetylation of dehydroalanine and dehydrophenylalanine peptides By Makowski, Maciej et al From Liebigs Annalen der Chemie, (7), 1457-64; 1985 Copyright © 2010 American Chemical Society. All Rights Reserved. CASREACT contains reactions from CAS and from: ZIC/VINITI database (1974-1999) provided by InfoChem; INPI data prior to 1986; Biotransformations database compiled under the direction of Professor Dr. Klaus Kieslich; organic reactions, portions copyright 1996-2006 John Wiley & Sons, Ltd., John Wiley and Sons, Inc., Organic Reactions Inc., and Organic Synthesis Inc. Reproduced under license. All Rights Reserved. SciFinder® Page 20