阿司匹林胃漂浮微球的制备的论文
阿司匹林胃漂浮微球的制备的论文
【关键词】 胃漂浮微球 摘要:目的 制备阿司匹林胃内滞留漂
浮微球。方法 以乙基纤维素为载体
材料
关于××同志的政审材料调查表环保先进个人材料国家普通话测试材料农民专业合作社注销四查四问剖析材料
，采用乳化―溶剂扩散技术
制备阿司匹林微球，通过正交试验优选制备工艺，并对微球的体外漂
浮性能，包封率，载药量，释放度等理化性能进行考察。结果 该法
所制微球形态圆整，大小较均匀，粒径范围45~200 μm，载药量为
32%，包封率为20.5%，体外12 h漂浮率为37.6%。结论 本微球制备
工艺较简单，重现性好。体外呈现较好的漂浮性能与缓释特性。 关
键词:阿司匹林; 胃漂浮微球; 乳化―溶剂扩散法; 乙基纤维素
abstract: objective to develop a floating oral delivery system of aspirin in hollo microspheres.methods the aspirin microspheres ere prepared by emulsionsolvent diffusion technique using ethyl cellulose as carrier polymer. the technology as optimized by orthogonal test. the physicochemical properties of microspheres such as buoyancy,drug loading,encapsulation efficiency and in vitro drug release ere investigated. results the prepared microspheres ere spherical ith a size distribution range beteen 45 and 200 μm. the drug loading capacity and encapsulation efficiency as found to be 32% and 20.5%,respectively. the floating rate after 12 hours as 37.6%. conclusion he preparation technique of floating aspirin microspheres is simple and reproducible. the enhanced buoyancy and sustained in vitro release properties of the microspheres make them a potential candidate for floating drug dosage systems. key ords:aspirin; floating oral microspheres; emulsionsolvent diffusion; ethyl cellulose 阿司匹林是具有百年历史的传统药物，
近年来在临床研究中不断发现其新用途，小剂量(75~160 mg/d)的
阿司匹林具有较好的抗血栓作用，临床
表
关于同志近三年现实表现材料材料类招标技术评分表图表与交易pdf视力表打印pdf用图表说话 pdf
现为防治心肌梗死和缺血性
脑血管疾病,1,。WW.11665.阿司匹林为弱酸性药物，在胃及小肠上
段易吸收，但对胃肠道黏膜刺激性较大，长期服用易诱发胃肠道溃疡。
本实验以阿司匹林为模型药物研制多单元型胃内滞留漂浮型给药系
统and floating behavior ,j,. j controlled release,1991，
16:279. ,7,国家药典委员会.中华人民共和国药典:二部,s,.
北京:化学工业出版社，2000:附录75. ,8,yasunori s,yoshiaki
k,hirofumi t,et al. physicochemical properties to determine the buoyancy of hollo microspheres prepared by the emulsion solvent diffusion method,j,. eur j pharm biopharm,2003,55:297.
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