【doc】MMP-3和CollagenⅢ在盆底器官脱垂患者阴道壁组织中表达的研究

【doc】MMP-3和CollagenⅢ在盆底器官脱垂患者阴道壁组织中 表 关于同志近三年现实表现材料材料类招标技术评分表图表与交易pdf视力表打印pdf用图表说话 pdf 达的研究 MMP-3和Collagen?在盆底器官脱垂患者 阴道壁组织中表达的研究 43?s???>???6??2008??10?9?A6???A19?JGuideofChinaMedicine,October2008,Vo6,No.19 ?9?1???H[J].?????s?>?s???Y??,2007,2:48-49. [17]???J?1?d?p????.?S?z???L???s???L???1??[J].?????S???>???Y ???d2006?d11?91?G?r56-57. [18]OhuchiS,IzuotoH,KamataJ,etal.Acaseofaconitine poisdoningsavedwithcardiopulmonarybypass[J].Kyobu Geka,2000,53:541-544. [19]??????.???????0?????y???L???s?????????w?B?L??????[J].???? ?s?>??,2002,31?94?G:9. [20]???Y??,?????(.?????????0???????S?z?S?????L???s???L?????? [J].?????s?>????????,2002,20?94?G:57. [21]??????.?????????????L???s??26???L??????[J],?????s?>??, 1999,30:51. [22]?=???J.?????????????z?????w?B??????[J].?s???>???????Y??, 2004,20?911?G:664. [23]LinCC,ChouHL,LinJL.Acuteaconi-tinepoisoned patientswithventriculararrhythmiassuccessfullyreversed bycharcoalhemoperfusion[J].AmJEmergMed,2002,20: 66-67. [24]???.??,???s??,???g???d??.?x?????,???????L???s??[J].?s?? ?????Y??,2001,40?91?G:502. 1?W???o???? 1.1???????????1?? ?G??2006??10?9??2007??6?9?????z???A?G?W???>???????P?? ??POP???830???9POP???Gv4???????(?d?J?G???????????z???????? ?????????6???;??POP?,?????z?U?w?????820??v3 POP?????G?????r???????????z?U?w???????d?6??????v4?? ??????v4?U?????????????????U?w???d?????????/?G?s?????u?L???? ????v3?????????G?????r???U?w???????V???????????L?????????,?? ???w???V?g?o???1?????????(???????????3???????????]????????v3 ?x?????G???8?/?m???????]????v3 1.2???????? POP???????B?????H?L?f?,???f?????6???gv3?6?????8?L???? ??12???0?????d???i???????H?J?1???L?F?1?O???x???d?????R?????G ?s?z?a??????10%?y???????s????24h?d???o???7?8??v3?????6?A?? HE?????o?d?????i?????????????4?d???G?????6?Av3 1.3???Y ??????MMP-3?r????????v4??????Collagen7??r????????v4 SABC???Y???/?s????????????????v3 1.4???????,???? ???H???????,?????0?1?6?/v3???????0?1?o,???HSABC??,?d ??????????v3?6?/?B???w?7?L?,?d30%H2 02 ?>???????z???z?,?? ???d???????z???x?8?4???d?1?l????Collagen7?v4MMP-3????v4?? ?????????????]???J???]?e???z?,?????e?9???dDAB?R???d???H?]?e ???d?w?Lv4?f?ov4?4?/v3?????u???6?6????????v3 5???????,?????????1?? 5??G???e?????d???]???????,?/?u???(?G??5?m?????d?? ?m???????W5?F???/?V5????H?u???????????????G????????B DigitalImagingSystem?E???????(?????1???0???L?????????s MMP-3v4Collagen7??????????,?????????k?z?(???/?????)v3?P?o ???????/?)v3 1.6???????0?1 ?????W???????(,???HSPSS11.5????????????t?????d?6 ?6???????z???HPearson?????1???d?/??P?N0.05???(?????L??v3 2???? 2.1POP???????>?????????] ????POP???J???>?????]?G???8??????v4?1?K?7??,?u???>?? ???]????????v3?????h?????1???d???5?????0???]?????d???3?/???R ???z(P>0?o05)?d???o2?????????G?????z,????1v3 2.2MMP-3?H?e?d???l?????s?????? MMP-3?k?z???????(???????d?>???????????H?,???B?d???? ?]?6?/?H???e???i?????d?K?H?????(???????????????????)v3?????? ??????2v3 MMP-3??Collagen7??H?????????w?????8?L?????????s???????M?? ???]?e1 ?]?g?? 2 ?????J 3 vC????vh?????????????????w???9POP?G???8?????g?4?????s???????:???4?d?1?????????:?o???????J??????v3???????H???????,?????d ????30???????????w?????8?9POP???G?d???G???d?J20?????????z?????d???????6???g?8???(????(??????)?d?????g?s?????8?L???????d???H?? ???????,??????????MMP-3??Collagen7???????????v3????POP???L???????????sMMP-3?????o?R??????????(P<0.05)?dCollagen7????????o ?R??????????(P<0.05)v3????POP???8?L???????????s???????:?>??v4?????1???????????gPOP???????(?P????v3 vC???p??vh?????V?????w???V???H???????????V???????? ?s???1?????rR711.2???p?6???4?rA?????,???r1671-8194?92008?G19-0043-03 ?????4?????3????????????????(53) ?????4?????z???A?G?W???>???,??(55) 3?????4?????3?????>???,??(55) ??12?????8???JPOP???>?????????]????() ??22?????8?????sMMP-3???? ???rSUI???o??????????P<0.05 1. 400 iosens 14100 24002 4002 2008??10?9?A6???A19?JGuideofChinaMedicine,October2008,Vo6,No.1944 2.3????????????3v3 Collagen7??H2?????8?L???????????s?/?????????d?k?z?????? ?=???????,???C???????d???B????v3?K?H?????(?????????????????? ?)v3????????????3v3 2.4POP??MMP-3?oCollagen7??????L?????????z?1?? ??POP???L?????????sMMP-3?oCollagen7??????????/???? ?)?????????z?1???d?????(?rPOP??MMP-3?oCollagen7??????L ???=?R???J????(r?.-0.242?dP<0.05)?d????1v3 3???? ?????f???w??(POP)?8???J?????w??????????v4???????f???w ???L???d?g?4???????B???????d???s?J?????w???8???????w?????L?? ???o???w???d?A?M???sPOP???8???8???L???????w???????z???8v3?L ???????w???g?6?z?L?L???????????????????U???d?w???L?????????? ???w?d?????h?i?????d???????r???L??????v3?L???????w?????????? ???H?d?????9???????w?????L???o???w??v3???x???/???????????d?? ?????=?C?C????????[1] ?d???(?????????(?P???????G?????????????? ?????y????????v3 ?????g?4?????>???g???????I???????d?w??????????v4?C???? ?????????????C?d???g?4???k?????????>?????????????,???H?s?e?d ???????????????????H?d?>???8??????????v4???????mv4?D?z????v4?Y ???????????????????d?;?z???1?g?w??????????v3?????g???I???g?4 ???H???>???C?1?d?>???w7?????????7??????????Cv37????????o?g?4 ???H?G???d???????z?d?????????V7????????????????d?o?????D?z?G ??v3???r???8???????H?????z?U?w?????????????w??(pelvicfloor prolapse,POP)?????s?????H???????M???d????SUI??POP???8?L ????v4?>???????????d???????????1???I?s?????l???/?????B????[2] v3 ?H?A?????s?dPOP?????8?L?????????s7????????????????o?R???h?? ?g?4???????????d???w?????????????g?w???????????h?????????Iv4 ???????g?4?????????V?d????????POP?????Jv3 ???????d????POP???8?????g?4?????s????????(collagen)?l ??v4????v4???????????????3?B?????????z???M???d?????l???? ?????M???>?????s?H?????9?C?????:?L??v3???H?????????? ?9x,MM?G???????????x???????s?r ???????????????????:?????d?g?????,???H???????i?s???????? ??v3?????z?????????????P???9tissueinhibitorofmetalloprot- einese,TIMPs?G???o??????MMP?????????>?,???f???????9?d ???PMMP?????J???>?z?d???P??????????????[3] v3?M???????d?? ???,???H?sMMPs?oTIMPs???w???o?r?????1???4?G???d?5???g?o ?????????:???6????v3 3.1MMP-3v4TIMP-3?????z?o???? MMP?g???????d?????z???6???????d?H???H?????r?????????? ??????v3MMP-3???????H?????]1(Stromelysin-1)?d?????1???H ?????(57??103 ?d?w??????v4?????????,?(???Cv3MMP-3?????? ?????oMMP-1???)?d?B?w???M???H????v4?C????????v4?????x???? ??????v4?????????????5???????J?d???H?????????d????????????v4?? ??????v4?Y????????v4??????????????7?v47?v47?v47?v47?????????v3 MMP-3???>?z????TIMP-1v4TIMP-2v4TIMP-3?x???Pv3 TIMP-3?gTIMPs?s?????C???d???????p???s?????????????J ?,???z???M??v3TIMP-3?>???w?????s???Y???????????x???J?d TIMP-3??MMPs?G???,???2???????????????????,?????????)???? ?,[4] ?d??1:P1???1???????oMMPs?????,?>?z???????????9?d?? ?d???PMMPs?????>?,?????>?zv3?o????TIMPs?e?d?dTIMP-3???g ???????9ECM?????????z?????d?oTIMP-1v4TIMP-2???G2578?? ?d???z[4] v3?M???????dN?l???gTIMP-3???PMMPs?>?z???????? ???(?d???????????H?????????oMMPs?d?????>?z?s?????9?d???d?? ?PMMPs???>?z???????Jv3 3.2MMP-3v4TIMP-3?oPOP MMPs?oTIMPs???????H???4?????d??2?8?????w???d?1?r ???J?????O???1???,v3?L???uSUI?oPOP?B???L???J?d?M?????o2 ?8?G???d???????(?P?d???G????????MMP?HSUI?????(?P?s???M ??????MMP?????o??POP?????Jv3??MMP?HSUI?s???M?????? ?1?????i?rChen??[5] ???????????z?U?w?????z?o???????L???????? ?sMMP-1v4MMP-2v4MMP-9???????PTIMP-1v4TIMP-2?? TIMP-3mRNA??????v3?R?(?H???z?????z?U?w????TIMP-1 mRNA???????h?dMMP-1mRNA?????????d???o?????L???? ??????????????v3???G?M??????,?J?????w?????8?????l?????h?o?? ???????????>?z???(?G??v3 ?A?M???????dPOP???L?????????sMMP-3?????????l???/?? ???B???o?R????(P<0.05)v3???(POP?????J?????g?w??MMP-3?? ?r?d?r?????????????????????????g?4???????w?d???JPOPv3 ???u?x???dPOP???8?L???????s???HMMP-3?????????(,7? ???????????????????d2?8?????=?J?????????d???(?????g?w?? MMP-3???(?????d???L?????????s7???????????????,??????POP ?????Jv3????,????MMP?????????:?oPOP???Jv4???????????M ???d?r?0???.???P???d?????o?????????G???r?????G??????????v4?? ???????M????????v3 ???2???p [1]YuCK,ChiuC,McComackM,etal.Delayeddiagnosisof cervicalcancerinyoungwomen[J].JObstetGynaecol, 2005?d25:367-370. []L,B,f,qy fy7? []UR,,(5)3336 ??32?????8?????sCollagen7????? ???rSUI???o??????????P<0.05 ??1MMP-3?oCollagen7??????????? matrimetalloproteinasePs 2iapisaakasPPaitiAetal.Changesintheuantit ocollagentpeinwomenwithgenuinestressincontinence J.roles200028:2-2. 45?s???>???6??2008??10?9?A6???A19?JGuideofChinaMedicine,October2008,Vo 6,No.19 [3]BrewK,DinakarpandianD,NagaseH.Tissueinhibitorsof metalloproteinasesevolution,structureandfunction[J].Biochim BiophysActa,2000,1477:267-283. [4]ChungHW?dWenY?dChunSH?detal.Matrixmetallopro- teinase-9andtissueinhibitorofmetalloproteinase-3Mrna expressioninectopicendometriuminwomenwith endometriosis:arationaleforendometrioticinvasiveness[J]. FertilSteril?d2001?d75?r152-159. [5]ChenBH,WenY,LIH,etal.Collagenmetabolismand turnoverinwomenwithstressurinaryincontinenceand pelvicprolapse[J].IntUrogynecolJPelvicFloorDysfunct, 2002,13(2):80-87. ?????h?x???????C?(?????h???s?4???????????????J?????>???? ??v3??????????v4????????v4?????????????????????????????????? ?????=????????v3???s???q?g?r?q?>???7?f?d?g?????????????U???1 ?7?fv3?h????2007??4?9??2008??6?9?P?????S?z?(?x?z?h???s???8 202??,?1?(???s???q???????r??????v3???s???q???H???s???q???1?7 ?f?i???????9????,?P?v?????=??,?????????i: 1?W???o???? 1.1?????W??v? 2007??4?9??2008??6?9?h???????????x?G?I?9?????6???????? ?d?f???S?z?h???????8,?G???????A?????h?x???????g?r???r???????? ?6??[1] ,?x?G?????/?(?.???z?h???????8,?1?l?P?????s???q?????r?? ?Uv3?????6??:???L?????????????????z?h???????8v3???s???q??134 ???d?%81???d??53???d????25??83???d???/61.39??12.70???d?? ????????????????(NIHSS)?((11.03??4.79)?1v4?J?>????????(BI)?( (60.34??27.38)?1v4?D??RanKin???????1(2.94??1.19)?1v3???r?? ?U??68???d?%40???d??28???d????41??81???d???/????63.93?? 10.09???d??????????????????(NIHSS)?((11.42??5.38)?1v4?J?>?? ??????(BI)?((56.32??34.86)?1v4?D??RanKin???????1(2.88??1.44) ?1?d???8???z?lv4????v4???rv4??????????v4???????????5???/???G ?????z(?v>0.05)v3 1.2???????????????6?6 ??????????v4????????v4????????????(NIHSS????)v4?J?> ????????(Barthel?6??,BI)v4?D??RanKin???????1,?1?l?H?????o24h ?????????????1,???o???????11?7,????????1?7v3???8???????D?H ?????????C?8???(??v3 1.3????????v? ???s???q??:5??D??vu?s???h?x???y???6??vi???s?????s???? ?s???,????vu?h?x???????L?????2vi?,?????3?9?h?????????6???V5? ?C???w?L???>?9v4???e?9v4?????9v4???1?????9v4???????C?????s?f ???V5?????vu?????6??vi,???9????????,?????????????????e?? ???d???????8?P????????????????;5??(?2???e?????J????,???J???? ???k???d????48h?o?????????e????v3???e?>?9???o???U,?????? ?????8?????????5???????i?????????v,?P?o?P?????e???n,???w???? ???????9?<??,???????i?=?d???s?f?????U?d????????????????v4???e ????v4???1???4???????????????d???2?????e???=v4???1?????????? ????;5??????????????????8???????1?????d???G???1???1?????????8 ???????1??????????;5??w???e?>?9???a?????????J????????????;5? ?C?????????????(?>,?????,??v4???x??????v4???1????v4?????R?0 ??v4?S???>?????????d???o???r?a????????v3???r???U???G???]???? ???????????????????????d?????9???P?????????r???U???8???e????, ?;?e?g?B??,?w?L???>?9???>?w????v3???L??CT?????,,???6?????? ????,???B??????????v3 1.4??????????v? ???HSPSS9.0?????1??v3 2???? 2.1??????????v4NIHSSv4BI??Rankin ?????????????s???q??2.2%(3/134),???r???U??8.8%(6/68),?? ?s???q??????????(P<0.05);?5??INHSSv4BI??Rankin???1?d???s ???q???d???r??????????,???1?G?R???z???l(P<0.05)?d????1??3v3 ???s???q???1???S?z?(?x?z?h???s???J???=?????? ?7?????=?????????q?]?B?????V???k?t?.?????k?? vC????vh?????r?????S?z?(?x?z?h???s???8??NIHSS???1v4???B?J?>???????1(BI)v4?D??RanKin???????1???????D?H?d?1?????s???q?????? ?=??????????????v3?????????????s???q(n=134??)?????r???U(n=68??)???S?z?(?x?z?h?x???????8?????????J??NIHSS???1v4?J?>???????? (BI)v4?D??RanKin???1???????D?H?????1??,????SPSS9.0???????????1?????s???q???????=??v3???????s???q?????r???U??NIHSS???1v4BI ?6??v4?D??RanKin???????1?o?R?D???dP?N0.05v3?????>?D?H???R???????dP& gt;0.05v3???????s???q???o?R?????h???s???8???????????(???d ???????B?J?>????,???????8?????i???d?;?x???????D?????r???U???8???R??????,?? ?s???q???D?????8???x?d?;?????D?H???o?R????v3 vC???p??vh???s???q;?S?z?(?x?z?h???s;?=?????? ?s???1?????rR743.3???p?6???4?rA?????,???r1671-8194?92008?G19-0045-02 ?????4???????A?????h?>??(66) ??:5??o???r??????????,P<0.01;5??o??????????,P<0.01 ??1???????o?5??NIHSS??????(,?1) ??2???????o?5??BI??????(,?1) ??5??o???r??????????,<5;5??o??????????,< 1100 :P0.0P0.01