CALCIUM CITRATE
Prepared at the 19th JECFA (1975), published in NMRS 55B (1976) and in
FNP 52 (1992). Metals and arsenic specifications revised at the 59th JECFA
(2002). An ADI 'not limited' was established at the 17th JECFA (1973)
SYNONYMS INS No. 333
DEFINITION
Chemical names Tricalcium citrate, tricalcium salt of 2-hydroxy-1,2,3- propanetricarboxylic acid,
tricalcium salt of ß-hydroxy-tricarballylic acid
C.A.S. number 813-94-5
Chemical formula C12H10Ca3O14 · 4H2O
Structural formula
Formula weight 570.51
Assay Not less than 97.5% after drying
DESCRIPTION Odourless, fine white powder
FUNCTIONAL USES Sequestrant, buffer, firming agent
CHARACTERISTICS
IDENTIFICATION
Solubility (Vol. 4)
Very slightly soluble in water. Insoluble in ethanol.
Test for citrate (Vol. 4)
Passes test
Test for calcium (Vol. 4)
Passes test
Test a solution obtained by igniting 0.5 g of the sample at as low a
temperature as possible, cooling and dissolving the residue in 10 ml of water
and adding 1 ml of glacial acetic acid.
PURITY
Loss on drying (Vol. 4)
Not less than 10% and not more than 14% (150o, 4 h)
Fluorides (Vol. 4)
Not more than 30 mg/kg (Method I or III)
Free acid and alkali Passes test
To 1 g of the sample, add 5 ml of water, shake well for 1 min, and add 2 drops
of phenolphthalein TS. No pink colour is produced. Add 0.5 ml of 0.1 N sodium
hydroxide. A pink colour is produced.
Oxalate Dissolve 1 g of the sample in 5 ml of warm dilute hydrochloric acid TS and
filter the solution if necessary. Add 2 g of sodium acetate and dilute to 10 ml
with water. No turbidity is produced within 1 h.
Lead (Vol. 4) Not more than 2 mg/kg
Determine using an atomic absorption technique appropriate to the specified
level. The selection of sample size and method of sample preparation may be
based on the principles of the method described in Volume 4, “Instrumental
Methods.”
METHOD OF
ASSAY
Weigh accurately about 350 mg of the sample, previously dried at 150o for 4 h,
dissolve in a mixture of 10 ml of water and 2 ml of dilute hydrochloric acid TS,
and dilute to about 100 ml with water. While stirring (preferably with a
magnetic stirrer) add about 30 ml of 0.05 M disodium ethylenediaminetetra-
acetate from a 50-ml buret, then add 15 ml of sodium hydroxide TS and 300
mg of hydroxynaphthol blue indicator, and continue the titration to a blue
endpoint. Each ml of 0.05 M disodium ethylenediaminetetraacetate is
equivalent to 8.303 mg of C12H10Ca3O14.
CALCIUM CITRATE
SYNONYMS
DEFINITION
Chemical names
C.A.S. number
Chemical formula
Structural formula
Formula weight
Assay
DESCRIPTION
FUNCTIONAL USES
CHARACTERISTICS
IDENTIFICATION
PURITY
Free acid and alkali
Oxalate
Lead (Vol. 4)
METHOD OF ASSAY
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