迷走神经刺激创伤性脑损伤：可产生神经保护效应
SICENCE新闻发布 作者:周龙 稿号:NRR_263_14
迷走神经刺激创伤性脑损伤的神经保护效应
迷走神经刺激创伤性脑损伤:可产生神经保护效应
有研究显示迷走神经刺激能够对癫痫、帕金森病等疾病发挥脑保护作用。本课题组以往的研究结果表
明刺激迷走神经还可改善创伤性脑损伤的预后。来自中国厦门大学东南医院周龙所在团队在以往研究
的基础上，进一步探索了迷走神经刺激对兔脑爆炸伤的保护作用及其对创伤性脑损伤功能预后改善作
用的机制。结果发现，迷走神经刺激可减轻兔脑爆炸伤后脑组织水肿程度，下调血清及脑组织内促炎
因子肿瘤坏死因子α、白细胞介素1β的表达，上调抗炎因子白细胞介素10的表达，以此发挥了创伤
性脑损伤起神经保护效应。文章发表在《中国神经再生研究(英文版)》杂志2014年9月第17期。
苏木精-伊红染色显示，电刺激后迷走神经脑爆炸伤兔脑组织部分神经元溶解坏死，细胞核结构不清，
尼氏小体消失(白色?示);部分神经元包体肿胀(黑色?示)，间质疏松、轻微水肿;血管轻度扩张，
红细胞贴壁(?示)(×400)
Article: "Neuroprotective effects of vagus nerve stimulation on traumatic brain injury," by Long Zhou1,
Jinhuang Lin1, Junming Lin1, Guoju Kui1, Jianhua Zhang2, Yigang Yu1 (1 Affiliated Dongnan Hospital of Xiamen
University, the 175 Hospital of Chinese PLA, Trauma Neurosurgery Center of Nanjing Military Region, Xiamen, Fujian Province, China;2 The 73131 Corps of Chinese PLA, Xiamen, Fujian Province, China)
Zhou L, Lin JH, Lin JM, Kui GJ, Zhang JH, Yu YG. Neuroprotective effects of vagus nerve stimulation on traumatic brain injury. Neural Regen Res.
2014;9(17):1585-1591.
欲获更多资讯: Neural Regen Res
Neuroprotective effects of vagus nerve stimulation on traumatic brain injury
Previous studies have shown that vagus nerve stimulation technology is important for neuroprotection in diseases such as epilepsy, Parkinson’s disease, and Alzheimer’s disease. However, at present, the role of vagus nerve stimulation in the treatment of traumatic brain injury remains unclear. Long Zhou and co-workers who come from Dongnan Hospital of Xiamen University, China aimed to elucidate the mechanism of the neuroprotective effects of vagus nerve stimulation in
SICENCE新闻发布 作者:周龙 稿号:NRR_263_14
rabbits with brain explosive injury. Their findings suggest that vagus nerve stimulation may exert neuroprotective effects against explosive injury via regulating the expression of tumor necrosis factor-α, interleukin-1β and interleukin-10 in the
serum and brain tissue. The relevant study has been published in the Neural Regeneration Research (Vol. 9, No. 17, 2014).
Vagus nerve stimulation group: partial neuronal dissolution and necrosis, unclear nuclear structure, disappearance of Nissl bodies (white arrow); some neuronal swelling (black arrow), loose stroma, slight edema, slight vasodilatation, and adherent erythrocytes (arrowhead) (hematoxylin-eosin staining, × 400).
Article: "Neuroprotective effects of vagus nerve stimulation on traumatic brain injury," by Long Zhou1,
Jinhuang Lin1, Junming Lin1, Guoju Kui1, Jianhua Zhang2, Yigang Yu1 (1 Affiliated Dongnan Hospital of Xiamen
University, the 175 Hospital of Chinese PLA, Trauma Neurosurgery Center of Nanjing Military Region, Xiamen, Fujian Province, China;2 The 73131 Corps of Chinese PLA, Xiamen, Fujian Province, China)
Zhou L, Lin JH, Lin JM, Kui GJ, Zhang JH, Yu YG. Neuroprotective effects of vagus nerve stimulation on traumatic brain injury. Neural Regen Res.
2014;9(17):1585-1591.
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