植物转基因技术生产疫苗进展

植物转基因技术生产疫苗进展 (),?w,?????]????,?????:?,???j?3?????e?h???1?r????????,????,?M?????2?S?8???h???? L) ?A???????????W?h?????????? ?????????????D???'?? (?????:?,???j?3?????e?h???1?r????,????????678000) ????:???????A???????W?8?A?????????9???W?1?S???????S?8?????:,???r???????a?? ?A??????,???h?????? ?????????)????????????????,??????????????,???;????L(????L(?;?O?j?o??L)?T?????A ?????????9??????????, ?n?????????9???????????K??????L)?d???????M???Y,???????n???????????d?A???Y? ??L??????,?????????????? ??????L) ???F??:???????A??;????;???? ?Y???8????:Q94???F?0???(:A?????r??:1008-6587(2008)02-052-04 ?????W???????r?????h???????H?????????G ?;?????r?????????h??(??????)L)?t?d?????????? ?r?H????????,?r?7?d?????????'?????????%?h?? ?TL)?r?7?d???????8???????????d???S????,???? ???????r???????5????????L(?????????????h???? ?H?PL(???4???b?????????h???z??L)???d?I?????W ?h?????????d?%????????????L(?;?????dL(?A???? ?j????L)???%?A???h?8???A?????????9???W?????? ???5??,???n?????????7?8?h?????????h??,???? ?t?d???h???????????????????S?????????????2 ???A???S???????r???????h?????d??????????L)?? ???P?n???A???????????P???8??,?????i???????? ?:?)???????????????n???????8?r?r?????????? ?8?r?M?????5???????A?iL)?4???????d?????p???Q ???????T????,?8???????????r?L?A??????,???? ???????????T?????5?S?A???????T????,?K?????i ?A???????T???P,???????????d?A??????,?A???? ???????????9?'?W?t?d???????P?????????r?(?H ?d?H?P?????dL(?n?????????????????A??,???A?? ???h?P???h?????d????L(???d?????j,?A???????d ?5?S???;???????????k???)?????????h??????L) 1.?A?????????9???????h?????? ?r?????????r?A???????h???????????????% ?8???h???????W???????4?A?????rL)????,?t?d?? ?????A???h?????????H???????;?g??:?v???????? ???????(????????L) 1.1?v?????????? ?????????W?8?????????????d?A?????????? 2008??3?:?????:?3????Mar.,2008 ?y27???y2?hJournalofBaoshanTeachersTbCollegeVol.27No.2 ProductionVaccineProgressofPlant TransferGeneTechnology YinFei,WangJianyun,YuLi,YanAifen (BaoshanTeachers'College,Baoshan,Yunnan,678000) Abstract:Planttransfergenevaccineistounifyplantgeneticengineeringtechnologyandorga nismim- munitymechanism,toinputextraneoussourcegeneintoplantsoastoproducenewvaccinetha tenables humanbodytoobtainspecialimmunityability,whichischeap,safeandeffective,comparedw ithother vaccines.Theoutputintraditionalplantgeneticengineeringvaccineislow.Newimproveme ntmethod throughthegeneticengineeringhasbeenmade.Intherecentresearch,themoreandmoreantig enprotein intheplanthavebeentestedinbothanimalandhumanbody. Keyword:Transfer-geneplant;Vaccine;Progress :2008-01-20 :1978- ,?t?d???]???r?7??????????????,?8???????? ???r?L?A???????Y???1?A???????????:,?????v?? ?????????????A?iL)?d???????????Y???????O???? ?????W?z?8???F??,?????H?????dCaMV35S???5 ???????W????,?]???????p??????L)?????'?????? ?d???????A?????S?????????????????????????? ?)??????????,?????5?????????????????H???;?? ??????????????????(HBsAg)L(?P???]?????????? ?TL(????????????????????????????(Norkwalk)?? ??????????L) 1.2???(???????? ???W???????????S??????????????????,???? ???W?8???????????????????????Y,???5?????? ??,?x?1?8?????????????L?A???????Z?Q,?????3 ??,?r???????????????A?x?4???O????L)???????? ???8?S?g?????-:?????W?8???????????????????? ???W?????9;?????W?8?????????1?????r???????? ?????:?d????L)???S???????????????????W???? 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(SEKDEL)???I???r?(???JL)????6???W???d???? ????????,???;???%???????r???????d???d???Y?W ???????dL)?????????2?????????W?8?r?????????2 ????????L)?n?????r?(??????DNA???:???????? ?????????r?I??????,?d?)?????????????,???9, ?????d???d???????Y?:?5L(?W??L)?d???????Y???? ?r??????,???????????P?P????L)?d?????????r?? ?A???????Y??????????????,?????????????????? ???T?????????A?????4?????h???n?w?P??????L) D?j??????TB?d???j???Z???????Y???? ??54???????:?3?????y27?? aniellC- ,???????1CT-B??????????????????4.1%L)?4 Tregoning?j?8?p?g????????C?Z??(TetC)???r?L ???j?????????Y,????????????????????25%L) 5.???l ??????,???%???T???W???A?????????9?????? ????,????(??????????L(?H???????????I???????j) ???M?????h????????L)?g???W?t?d???????A?????W ?h???A?????????M?????L????????????,?d?????? ?A??(?y??L(?p??L(??????)???????d?????????????h ?????r?????????d???????????????????W?S???? ?P???????M?x?????????M??,?????????????????? ??L)?A???????????????;???n?o??,?h???5?y??L(?3 ??????L(????????????L(?n???A?????????r?j?6?8 ?4???????dL)???????;???n???????A???????????? ?????????h??L)?d?A?????8??,?????n?????d???? ?;???????????????A??,?????B??L(???6?j?'???? ????????????????????,?4???????????6????L)?4 ???????n?????d?????;???????????A???????'?? ??????????????????????,???w?A???????(?P???d ????????????????????L(????,?????????W?????? ?T?????????????????????N????????????L) ???,???F: [1]GustavoA.delaRiva,JielGonz??lez-Cabreraetal. 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