抗精神病新药阿立哌唑（Antipsychotic drugs aripiprazole）

抗精神病新药阿立哌唑（Antipsychotic drugs aripiprazole） 抗精神病新药阿立哌唑(Antipsychotic drugs aripiprazole) Antipsychotic drug aripiprazole.Txt: "I envy some older people who envy them hand in hand until the last.". - pay the bill when they found themselves so valuable. This paper consists of 1308421381 contributions Pdf documents may experience poor browsing on the WAP side. It is recommended that you first select TXT, or download the source file to the local view. Shanghai psychiatry No. No. stage Overview Anti psychotic drugs launched Gua WOW Huang Wenwu Jiang Deguo , In the history of the search for antipsychotic drugs, human beings have never stopped making progress. Traditional antipsychotics have been discovered by chance, and have retained them , Receptor high pair , Receptors have two-way antagonism and agonistic action Receptor [[receptor] Screw, dragon, combine, measure and aim at That is . A pituitary gland in mice , On the basis of the mechanism of action, atypical antipsychotics have increased or decreased some , Receptor subtype protection assay The fluorine Gua suck alcohol , Prolactin . year Horizontal quantitative ribonucleic acid research , , The effect is more comprehensive and safer , , . Latest by , One Shi " Precious jade and Japan " The company developed a new type of antipsychotic aripiprazole Gua WOW to " , increase The Department of Screw joint ratio makes and Passed the United States in nineteen sixty " The review was hailed as the first ". Recipient Levels increased respectively year , Prolactin snail , Three generation antipsychotics Dopamine system stabilizer , This paper reviews recent years . Horizontal increase Uplift binding rate Decrease [ Decrease in levels . year come A comprehensive report on the drug is given in this paper send , Recipient and Pharmacokinetics Prolactin , No effect of sulpiride level respectively. . Increase when Recipient Clozapine . as Chemical name Two hydrogen Eleven one The name of the product is One , , The Chinese launched quack miles One , One Two chloro phenyl One One One It ca base Ding Jizhao oxide Eleven one , The inhibition of pituitary by inhibiting the action of receptor continuously is the basis of very few hyperprolactinemia in clinic , The cha , One , One which work One I. One Tuo Bu , "[ . In human body . Affinity for the family , One For humans , , One several ,, , Dopamine , Receptors are very high Oral bioavailability was Food has no effect on it Oral The receptor also has a higher affinity to the receptor and a receptor , One One Plasma peak concentration was reached after 24 hours One . The half-life of the parent drug The half-life of , hour hour , The adrenergic / histamine , Dehydrogenation of major metabolite . Force pair , , One criminal , Adrenergic One heart . , , , day , Metabolism is mainly mediated , , The form, dehydrogenation, de action, and trans The affinity of the field histamine receptor is low . Hepatic enzymes Substitute catalysis , , Tamar Inactivated and . In vitro test intestines , , In human The functional performance of the receptor clone strain, such as , Dehydrogenation is mainly dependent on the action of glycation, and is mediated by . Pakistan The [ Catalysis , Dynamic partial agonistic antagonism has a particular cellular type of selectivity, which selectively selectively affects dopamine and other biogenic amines, in particular In Sichuan . One " " After single oral administration Bid sign The mechanism suggests that it is functional in the human body , The volume distribution is Discharge from urine . Fecal excretion , . Intravenous homeostasis Its master . Receptor and , Receptors and options , One When treating blood levels , Bamboo receptor production interaction One The protein binding rate of the metabolite is Among them, mainly albumin Sure take off , Secretary heart Also found that it has a stronger Eleven one Through the blood-brain barrier and associated with dose , . A part of the excitement of receptor receptor antagonism and ondansetron on Qi Gung affinity is very low but with the receptor , ,, . Pharmacological action Unlike the classical nonclassical antipsychotic drugs listed, receptor agonists partially agonists ,, Or was it the first known as the dopamine system stabilizer? , " " as . than medicine . The normal stabilization of dopaminergic neurotransmission in the brain is achieved by balancing stimulation of presynaptic postsynaptic receptors , yes about , Dopamine . Presynaptic , Recipient , Receptor, it is both a presynaptic receptor agonist and a postsynaptic receptor antagonist The part of a brain tissue that is stimulated by a specific site of postsynaptic activity " The release is closed so that it can . Its receptor activity is reversed in the brain of rats Diamine synthesis . . Induced multiple Bu , Excessive concentrations or hyperactivity are controlled, while other dopamine system stabilizers are present . Two Also call , , Postsynaptic antagonism, however Two Normal activities are allowed The concept is that it can , Behavior can inhibit apomorphine induced catalepsy , When the level of nerve transmission is too low, this kind of medicine is also taken by the soup , In animal experiments Does not cause stereotypic behavior in the midbrain Maintaining or enhancing neurotransmission is known to reduce transmission function at too high a level , There is a typical antagonism on the pathway of limbic system Receptors function in the midbrain cortex , , Antipsychotic drugs, that is, it's right , , Receptor stimulation and occlusion " , But it's unique Amine transport "[]. The partial excitation of the receptor can be used simultaneously in the covered areas of Sichuan , Used just right, not too far, not too weak, like pseudo Hot "" Neurons are excited and antagonistic, and can inhibit dopa in the nigrostriatal pathway , It's too cold " . It can be lowered in the treatment of psychosis , Affinity ratio of receptor and The activity of improving positive symptoms was upregulated by low excitatory States , Neurons improve negative Physiological function does not affect transportation The symptoms and cognitive functions remained normal at the same time Author unit Department of psychosomatic medicine, Wenzhou psychiatric hospital, Zhejiang Dynamic function and prolactin levels . "China Academic Journal Electronic Publishing House. All rights reserved." Http://www.cnki.net curative effect An item cited Amine primary amine system stabilizer ,, , It is positive for schizophrenia, negative symptoms, and , , , Depression, anxiety and cognitive function have obvious curative effect, but safety is higher A randomized, double-blind, controlled trial was conducted to treat schizophrenia and schizophrenia , Special pharmacological features will lead to new explorations in the field of Psychiatry , . Results of research on sexual insanity The total score and positive symptom score were analyzed Years old can significantly improve , With fluoride alcohol can significantly improve quack sucking , Test . writing , offer One One The negative symptoms of the age scale and the fluorine scale were only , One One Li , , [ One , One . One . , Qingqing One , One , One nail name Changes in the incidence, weight, and prolactin levels were comparable to placebo and found in studies such as Sichuan . Yan intestines , Mao . Call two . , Play brother Ding Peng , One D & F " , , Risperidone , year persuade " beat , Two Servants , The efficacy is similar, but in terms of sustained efficacy and efficacy in depressed patients , Li , Higher than the rate of alcohol sucking fluorine Gua and risperidone similar to placebo does not affect patient's glucose tolerance of other than risperidone fast onset in improving negative symptoms , , , . Shantou. as if One Rather Eleven one , One , order A multicenter study will show that chronic stabilization is currently being used in other oral antipsychotics , Yan Knock day One ] La , , One , Households. , The schizophrenic patient is converted to Stop using the raw drugs immediately , Treatment ] . A total of three programs Gradually stopped in the week Dose in intestines Secretary of state One One K two bites plus . year , nail , TC , Two expand , Coffeeholic . Gradually stopping technology Gradually increase over the week Results the three groups can be safely transferred to single use " . . intestines , heart stare at , order , Fine One , , Treatment of psychiatric symptoms has been further improved One Qiao ADHD can be treated with attention deficit hyperactivity disorder . intestines , S , night common Flail used , But higher doses are less effective Security Admonish knife Two " , , , Clinical results showed that nature . . It has high safety and tolerance time , Merit] Luo Cheek currency Yan , , A Findings " [] It never happens No findings were found , More than earlier trials of receptor occupancy were also found in the continuing treatment of sperm , Bite of Science Noodles plus , , , Significant reductions in prolactin levels were observed in patients from immediate to long-term clinical trials Extended household Two , , blood household , " Today. Bite . A One Multicenter double blind randomized controlled trial group , .. , , [stay] Group abbreviation Two , , One , common BA One Noodles Brother's Placebo group Two The incidence of side effects was similar to that of the fluoro alcohol group , , , One Sit down The incidence of sleepiness was significantly higher than that of the former , group To our , , There was no significant correlation between sitting and dose, compared with placebo Main exercise scale Group not from Two , Qin , Animal intestines , The letter One , Hu companion Luo potassium The score decreased more significantly , Like the corpse Group slightly Ratio difference Turn Noodles heart , Degrees of weight change were not significant . , Association with fluorine and alcohol group , BA , , " sand , mountain in addition , There was no group Prolongation and serum prolactin gain ,, , , Secretary of state song high " Each other F currency site That lies Noodles Combination C Masi Bing Ding Ke makes ,, Inhibitor Palo Si Dean Sitiquini , Secretary of state Add up Commandment , " , Efficacy, plasma concentration, and drug toxicity were increased in red mold , A vegetarian capsule can reduce its concentration Salt does not affect its pharmacokinetics . . Famotidine, valproate, and rasp One , , , Dish Dish , , , stay Research , The pharmacokinetics of aged people over the age of 5 are still not better Dish Sichuan , . Gamma] , One There have been more common reports ,,, The side effects of the drug were anxiety head , ,, , , , A e , day " Pain, insomnia, dizziness, drowsiness, nausea, vomiting, urinary incontinence, stiff neck, cramp, occasionally One Suck while It is first Palmer seven" Bite There are sedentary, constipation, rash, cough, nasal congestion rare Tremor, fever, pain, myalgia, blurred vision , , , , , , , , . Lang One which , Namely. ton , , conclusion Resistance Is the first dopamine system stabilizer, also known as DOPA , , city department Thanks to a few wonderful , ] Shantou , city Girl One foot , . "China Academic Journal Electronic Publishing House. All rights reserved." Http://www.cnki.net One