妊娠与甲状腺疾病PPT课件

妊娠与甲状腺疾病 * 概 述 * 血清甲状腺素结合球蛋白（TBG）增加 血清绒毛膜促性腺激素（hCG）增加 胎盘Ⅱ型、Ⅲ型脱碘酶活性增加 肾脏对碘清除率增加 妊娠期母体TH产生和代谢的变化 * TBG对妊娠期TH水平的影响 TBG在排卵后第20天开始升高，20-24周达高峰，维持到产后数周 TBG水平是非妊娠时的1.5-2倍 血清TT4和TT3增加 血清TT4水平是非妊娠时的1.5-2倍 Mandel SJ, Thyroid.2005,15:44-53. * TSH hCG与TSH 有相同的α亚单位、相似的β亚单 位和受体亚单位,所以对甲状腺细胞TSH 受体有轻 度的刺激作用。由于这种刺激作用,在妊娠8～14 周可以导致垂体—甲状腺轴的抑制。血清hCG 的水平与血清TSH 水平呈现一种镜像关系。血清hCG浓度每增加10 000 IU/ L , 血清T4 浓度增加0. 6pmol/ L ,同时血清TSH 浓度减少0. 1 mIU/ L 。 * Changes in Thyroid Tests during Gestation iodine sufficient and no AITD Courtesy of Dr. C. Spencer This slide summarizes data from longitudinal studies of changes in thyroid test values throughout gestation. In iodine sufficient populations with no AITD, rising estrogen levels over the first trimester result in an approximately 2-fold increase in TBG which plateaus in the second trimester. In response, TT4 concentrations rise sharply over the first trimester and stabilize around mid gestation at roughly 1.5 times non- pregnant values. The hCG that peaks around 8-10 weeks gestation stimulates the thyroid gland and is responsible for a small rise in total and free T4. Thereafter FT4 levels fall progressively until the the end of gestation. As would be expected, the first trimester rise in FT4 is associated with a reciprocal suppression in TSH. Thyroglobulin and Thyroid volume assessed by ultrasound remain essentially unchanged. Thus, the physiologic changes that accompany normal pregnancy dictate the need for trimester-specific reference ranges for total and free T4 as well as TSH. * 　妊娠期母体甲状腺相关检测指标的变化 TSH TSH 是判断甲状腺功能的最敏感指标 美国甲状腺协会和疾病控制中心等组织根据目前的研究结果,提出妊娠早期母体TSH 水平的正常上限可能接近2. 0mIU/ L ,并将2. 5 mIU/ L 定为妊娠早期母体血清TSH水平的保守上限值 * 血清TT4/FT4 目前尚没有妊娠期特异的TT4/FT4参考范围 FT4波动较大，受检测 方法 快递客服问题件处理详细方法山木方法pdf计算方法pdf华与华方法下载八字理论方法下载 影响 TT4浓度增加稳定，约为非妊娠时的1.5倍 国际上推荐应用TT4评估妊娠期甲状腺功能 * 妊娠期母体甲状腺自身免疫的变化 妊娠对免疫系统的影响 妊娠与甲状腺功能亢进症 * 病 因 主要包括两种类型 妊娠一过性甲状腺毒症 ( gestational transient thyrotoxicosis, GTT )， 与hCG浓度增高有关 妊娠Graves病，与甲状腺自身免疫异常有关 GTT是妊娠早期甲亢最常见的原因 * 妊娠一过性甲状腺毒症临床特点 常在妊娠前三个月发生 是一种hCG相关性甲亢, hCG增高的水平与病情的 程度相关 无自身免疫性甲状腺疾病史 TRAb及TPOAb阴性 甲状腺功能的改变多为暂时性 妊娠剧吐一过性甲亢（THHG）：伴剧烈恶心、呕吐， 体重下降5%以上、严重时出现脱水和酮症 Kimura M,et al. Clin Endocrinol.1993 * 诊断与鉴别诊断 疑诊甲亢：体重不随妊娠月数而相应增加， 或四肢近端肌肉消瘦， 或休息时心率在100次/分 确诊甲亢：血TSH<0.3mIU/L，T3或T4升高 鉴别甲亢原因： GTT：一过性，不需治疗 妊娠Graves病：临床表现妊娠前5个月 症状加重，后5个月症状减轻 * 妊娠期甲亢的危害 母体：妊高症、先兆子痫、心力衰竭 甲状腺危象、流产、胎盘早剥 胎儿：宫内生长停滞、早产儿、死胎 先天畸形、新生儿死亡 足月小样儿：是正常妊娠妇女的9倍 新生儿甲亢：GD孕妇中患病率1-2％ Millar LK. Obstet Gynecol,1994, 84:946 –949. Momotani N. J Clin Endocrinol Metab, 1997,82:3633-3636. * 342例甲亢患者妊娠结果 ATD治疗组 手术治疗组 未治疗组 总样本数 265 43 34 死 胎 13（5%） 3（7%） 8（24%） 早 产 29（11%） 4（9%） 18（53%） 发育异常 3（1%） 1（2%） 甲状腺危象 5（2%） 1（2%） 7（21%） 未治疗组的死胎、早产和甲状腺危象的发病率较治疗组增加。经治疗控制甲亢上述疾病的发生率降低 Davis LE. Am J Obstet Gynecol,1989,160:63-70. 消化系统 食欲差，体重增加。腹胀，便秘，严重者出现粘液水肿性巨结肠或麻痹性肠梗阻。由于抗胃泌素抗体存在，50％患者胃酸缺乏或无胃酸。 呼吸系统 由于肥胖、粘液性水肿、心包、胸腔积液、贫血及循环系统功能减退等综合因素可导致呼吸急促，肺泡中二氧化碳弥散能力降低，从而产生二氧化碳增多甚至二氧化碳麻醉症状。 内分泌系统 女性常有月经失常，月经过多或闭经。男性性功能低下，性成熟延迟、阳痿。长期严重的患者可导致垂体增生，蝶鞍增大。原发性甲减，可同时出现泌乳素增高，甚至溢乳。如本病伴特发性肾上腺皮质功能减退症和1型糖尿病属多发性内分泌腺自身免疫综合征的一种，称为Schmidt综合征。交感神经的活性在甲状腺激素缺乏时降低，胰岛素降解率下降且患者对胰岛素敏感性增强。 泌尿系统及水电解质代谢 肾血流量降低，酚红试验排泌延缓，肾小球基底膜增厚可出现少量蛋白尿。由于肾脏排水功能受损，导致组织水潴留。Na+交换增加，可出现低血钠，但K+的交换常属正常，血清Mg2+可增高。 血液系统 可以出现各种类型的贫血，可能与下列四种原因有关。①甲状腺激素缺乏引起血红蛋白合成障碍，红细胞生成素减少；②胃酸缺乏使铁及维生素B12吸收障碍，肠道吸收叶酸障碍；③月经量过多；④与自身免疫性甲状腺炎伴发的器官特异性自身免疫病如恶性贫血有关。血沉可增快。Ⅷ和Ⅸ因子的缺乏导致机体凝血机制障碍，故易有出血倾向。 血脂代谢 甲状腺激素一方面促进肝脏胆固醇的合成，另一方面促进胆固醇及其代谢产物从胆汁中排泄。甲状腺激素不足时，虽胆固醇合成降低，但其排出的速度更低，血中总胆固醇浓度增加。久病者出现明显的脂质代谢紊乱，如高胆固醇血症、高甘油三酯血症以及高β－脂蛋白血症、高低密度脂蛋白胆固醇（LDL-C）血症。 粘液性水肿昏迷 见于病情严重的患者，常为年老长期未获治疗者。大多在冬季寒冷时发病。甲状腺激素替代治疗中断、受寒及感染是最常见的诱因，其他如创伤，手术，麻醉，使用镇静剂等均可促其发病。临床表现为嗜睡，低体温（低于35℃，呼吸浅慢，心动过缓，心音微弱，血压降低，四肢肌肉松弛，反射减弱或消失，休克、昏迷，可伴发心、肾功能衰竭，常威胁生命。 * 妊娠期甲亢的治疗 抗甲状腺药物治疗 首选 手术治疗 合适时机 放射性131碘治疗 禁忌 * 手术适应证及时机 手术适应证 对ATD过敏 抗ATD治疗效果不佳，不能规律服药 甲状腺肿显著，需要大剂量ATD 心理负担重，过度担心药物副作用 手术时机：妊娠4-6个月较合适 * 妊娠期ATD的比较 丙硫氧嘧啶 甲巯咪唑 胎儿/母体药物浓度比 0.27-0.35 0.72-1.0 胎盘通过率 低 较高 先天畸形发生率 3% 2.7% 胚胎发育不良 先天性皮肤缺损 气管-食管瘘 面部畸形等 药物选择 优先 第二线药物 * 妊娠期ATD的应用 最大剂量PTU 50-100mg，q8h 或MMI 20mg/天 治疗初期每2周查甲功，以后延长至2-4周一次 临床症状和甲状腺功能改善，ATD的剂量应当减半 多数患者在3-8周甲功恢复正常 当患者依赖最小剂量的ATD（PTU 50mg/天或MMI 5mg/天）维持甲功正常持续数周后，可以停药 目前主张维持治疗至妊娠32周，避免复发 如果复发可以再次用ATD治疗 * 治疗目标 尽小ATD剂量 尽快控制症状 尽早甲功正常，血清FT4 在正常值的上1/3范围 用FT4 作为监测甲状腺功能的指标 TSH水平不 能作为甲亢治疗时的监测指标 保证母亲和胎儿无并发症发生 　妊娠期甲亢要使用FT4 作为监测甲状腺功能的指标,因为孕妇血清FT4 水平与脐带血的FT4 水平显著相关, * ATD与其他药物的联合使用 ATD与LT4联合使用 合并L-T4后，ATD控制甲亢的剂量需要增加 所以妊娠期甲亢不建议合并使用L-T4 β受体阻断剂的应用 普奈洛尔（心得安）与自发性流产有关， 患病率为24.4%, 正常人5.5%；可能引起胎儿 宫内生长迟缓、产程延长、新生儿心动过缓、 低血压、等并发症，故应慎重使用 * ATD与哺乳 丙硫氧嘧啶 甲巯咪唑 乳汁/母体摄入量比 0.025% 0.1-1.17% 乳汁透过率 低 较高 药物选择 优先 第二线药物 Kampmann JP. Lancet. 1980. 1: 736-38 哺乳期使用PTU 150mg/天或MMI 10mg/天对婴儿 脑发育没有明显影响，应当监测婴儿的甲状腺功能 哺乳完毕后服ATD，间隔3-4小时再行下一次哺乳 * 甲亢患者妊娠的时机 既往患甲亢的患者，如在ATD治疗中，血清TSH达到 正常范围，停用ATD后或减少ATD的剂量，使血清FT4处于正常值的上限 部分学者主张怀孕前应当停用MMI，改用PTU， 避免MMI可能引起的畸形 甲亢放射碘治疗后的6个月内应当避免怀孕。 目前尚无证据证实放射性碘对胎儿和后代的负作用 妊娠与甲状腺功能减退症 * 母体甲减对妊娠和胎儿的影响 临床甲减比亚临床甲减发生上述的并发症危险更大 亚临床甲减妊娠并发症的危险性是否升高结论不一 Stephen H. Thyroid 2005, 15(1):60-71. 发病率（%） 正常对照 临床甲减 妊高症 3.8 11.6 自然流产 3.3 8.0 早产 3.4 9.3 围产期死亡 0.9 8.1 低体重儿 6.8 22 * 神经克汀病 先天性甲状腺功能减退症 MCT8 突变 (Allan-Herndon-Dudley综合征) 明显的母体低甲状腺素 妊娠中期 新生儿甲状腺发育不全或不发育 未知 可能的早期胎儿 * * 两个主要的综合征为神经克汀病和先天性甲状腺减退症。虽然神经克汀病是因母体中甲状腺功能低下导致胎儿甲状腺激素不足，但是损伤的根本原因是严重的T4缺乏。 问 题 快递公司问题件快递公司问题件货款处理关于圆的周长面积重点题型关于解方程组的题及答案关于南海问题 ：能够将母体”甲减”隔离吗？ Continuar con la siguiente o con la de berbel et al, thyroid？？？？ * 于孕16周前获取的 25,216例血清样本(经过3次筛查) 62 名孕妇 高水平TSH (>98%) 124名 对照组孕妇 正常水平TSH 对后代的检测(年龄在7-9岁) IQ, Language, Attention, Motor skills, etc. NEJM 1999;341;549 * * Maternal hypothyroidism is a cause for retarded development, as was shown in the study of Hadow et al. * 母体甲减对后代智力的影响 James Haddow et al N Engl J Med 1999; 341:549-55 妊娠17周妇女回顾性甲状腺功能 分析 定性数据统计分析pdf销售业绩分析模板建筑结构震害分析销售进度分析表京东商城竞争战略分析 病例 对照 P值 例数 62 124 TSH(mU/l) 13.2±0.3* 1.4±0.2 <0.001 TT4(ug/dl) 7.4±0.1* 10.6±0.1 <0.001 FT4(ng/dl) 0.71±0.1* 0.97±0.07 <0.001 TPOAb(%) 77* 14 <0.001 本病发病隐匿，病程较长，不少患者缺乏特异症状和体征。症状主要表现以代谢率减低和交感神经兴奋性下降为主，病情轻的早期病人可以没有特异症状。典型病人畏寒、乏力、手足肿胀感、嗜睡、记忆力减退、少汗、关节疼痛、体重增加、便秘、女性月经紊乱，或者月经过多、不孕。 * 母体甲减对后代智力的影响 韦氏儿童智力量表测定7-9岁儿童的智商 124名对照组孕妇的后代智商分值107±12 48名未治疗甲减孕妇的后代智商分值100 14名已治疗甲减孕妇的后代智商分值111 妊娠妇女未诊断的甲减会对后代神经发育 产生不良影响；如果对妊娠合并甲减者给 予L-T4治疗，儿童智力将不受影响 James Haddow et al N Engl J Med 1999; 341:549-55 典型病人可有表情呆滞、反应迟钝、声音嘶哑、听力障碍，面色苍白、颜面和/或眼睑浮肿、唇厚舌大、常有齿痕，皮肤干燥、粗糙、脱皮屑、皮肤温度低、浮肿、手脚掌皮肤可呈姜黄色，毛发稀疏干燥，跟腱反射时间延长，脉率缓慢。少数病例出现胫前粘液性水肿。本病累及心脏可以出现心包积液和心力衰竭。重症病人可以发生粘液性水肿昏迷。 * 母体甲减对后代智力的影响 在妊娠12周时母体低T4血症（血清FT4低下, TSH 正常（0.15-2.0mIU/L)），其后代在1岁、2岁时的智力发育和运动能力评分均低于正常对照 Pop，et al. Clinical Endocrinology, 2003, 282. 病例 对照 P值 1岁 智力发育 运动能力 95 91 105 99 0.004 0.02 2岁 智力发育 运动能力 98 92 106 102 0.02 0.005 血清促甲状腺激素（TSH）和TT4和FT4是甲减的第一线指标。原发性甲减血清TSH增高，TT4和FT4均降低。TSH增高，TT4和FT4降低的水平与病情程度相关。血清TT3、FT3早期正常，晚期减低。因为T3主要来源于外周组织T4的转换，所以不作为诊断原发性甲减的必备指标。亚临床甲减仅有TSH增高，TT4和FT4正常。 甲状腺过氧化物酶抗体（TPOAb）、甲状腺球蛋白抗体（TgAb）是确定原发性甲减病因的重要指标和诊断自身免疫甲状腺炎（包括桥本甲状腺炎、萎缩性甲状腺炎）的主要指标。一般认为TPOAb的意义较为肯定。日本学者经甲状腺细针穿刺细胞学检查证实，TPOAb阳性者的甲状腺均有淋巴细胞浸润。如果TPOAb阳性伴血清TSH水平增高，说明甲状腺细胞已经发生损伤。我国学者经过对甲状腺抗体阳性，甲状腺功能正常的个体随访五年发现：当初访时TPOAb＞50IU/ml和TgAb＞40IU/ml，临床甲减和亚临床甲减的发生率显著增加。 * 诊 断 妊娠伴甲减 妊娠前确诊甲减 妊娠期初诊甲减 妊娠期甲减的诊断 临床甲减： TSH升高，TT4/FT4降低 亚临床甲减：TSH升高，TT4/FT4正常 低T4血症： TSH正常，TT4/FT4降低 ATA：TSH正常（0.3-2.5mIU/L） TT4低于100nmol/L（7.8μg/dL） 根据病变发生的部位分类。①由于甲状腺腺体本身病变引起的甲减称为原发性甲减（primary hypothyroidism）。此类甲减占全部甲减的95%以上。原发性甲减的原因中自身免疫、甲状腺手术和甲亢131I治疗三大原因占90%以上；②由于下丘脑和垂体病变引起的促甲状腺激素释放激素（TRH）或者促甲状腺激素（TSH）产生和分泌减少所致的甲减称为中枢性甲减（central hypothyroidism）。垂体外照射、垂体大腺瘤、颅咽管瘤及产后大出血是较常见原因；③由于甲状腺激素在外周组织实现生物效应障碍引起的综合征称为甲状腺激素抵抗综合征（resistance to thyroid hormones，RTH）。 * 治 疗 L-T4为首选替代治疗药物 L-T4治疗目标和剂量调整 妊娠前确诊甲减，调整L-T4剂量，TSH正常再怀孕 妊娠期间，L-T4剂量较非妊娠时增加30%-50% 妊娠期间诊断甲减，即刻治疗，L-T4 2.0μg/kg/d 依据妊娠妊娠特异的TSH正常范围，调整L-T4剂量 有学者建议TSH 2.5 mIU/L作为补充L-T4的目标值 Mandel SJ, Thyroid.2005,15:44-53. J Clin Endocrin Metab. 2007 * 胎儿甲状腺功能的建立 妊娠第11周以前，胎儿的神经系统发育主要依赖母体的甲状腺激素。 从第11周开始，胎儿的下丘脑、垂体开始产生TRH和TSH，甲状腺开始摄碘。 妊娠第12周起，胎儿甲状腺开始分泌甲状腺激素。 妊娠26周，胎儿甲状腺功能完整建立。 妊娠第35～40周血清T4达到高峰，出生前血清TT4100μg/L，血清FT415ng/L，血清TSH8mU/L。 * 胎儿的脑发育和甲状腺激素 研究证实：母体的甲状腺激素几乎不能通过胎盘。一项从自愿者体内试验得到的结果证实，妊娠分娩前给予母体4～8mg的左旋甲状腺素（LT4），仅有1%-～3%通过胎盘。 近年来开始重视胎儿自身甲状腺激素产生以前的母体甲状激素的作用。妊娠第6周的胎儿体腔内已经发现T4的存在。妊娠第10周胎儿的脑组织内出现T3核受体，妊娠第12周和第16周，胎儿T3核受体分别增加了6倍和10倍。 这些结果提示在胎儿甲状腺工作之前，即妊娠的第4～6个月（T2期），胎儿的脑结构发育依赖于母体的甲状腺激素。从妊娠的第7～9个月（T3期）开始，胎儿的脑发育依赖于胎儿自身甲状腺产生的甲状腺激素 * 如果调整L-T4剂量，每2-4周测定TSH 达标的时间越早越好（最好在妊娠8周之内） TSH达标以后，每6-8周监测TSH、FT4和TT4 亚临床甲减妊娠妇女是否治疗目前尚无一致 意见 文理分科指导河道管理范围浙江建筑工程概算定额教材专家评审意见党员教师互相批评意见 L-T4应当避免与离子补充剂、含离子多种维生素、 钙剂和黄豆食品等同时摄入，应间隔4小时以上 Mandel SJ, Thyroid 2005, 15:44-53. 治 疗 * 孕期亚甲减的L-T4治疗 已服用L-T4的甲减患者，如仍处于亚甲减状态，应调整剂量，并注意患者的依从性 每4-8周随访TSH，调整L-T4的剂量 使TSH降至参考值范围的低值部分 L-T4的需要量在孕期明显升高 * 孕期L-T4需要量增加的原因 孕激素血症-----TGB水平增高，甲状腺激素结合容量增加，即血液中激素的游离部分减少 胎盘水平T4脱碘不足，妊娠前3月T4通过胎盘对胎儿神经系统发育、儿童期智商（IQ）很重要 HCG没能发挥作用 * 筛 查 对妊娠妇女做TSH常规筛查意见不一 主张者： AACE 鉴于甲减和轻度甲减对后代的危害 反对者：ATA 鉴于目前缺乏大规模前瞻性研究结果 Consensus Statement #2 ATA Statement Thyroid,2005,15: 77-79. Ladenson, PW. ATA guidelines Arch Intern Med, 2000,160:1573-1575. * 预 防 一致的观点：对甲减的高危人群做妊娠前的筛查 甲减的高危人群包括 有甲状腺疾病个人史和家族史者 有甲状腺肿和甲状腺手术切除和131I治疗史者 既往发现血清TSH增高或甲状腺自身抗体阳性者 有其他自身免疫性疾病个人史和家族史者 Consensus Statement #2 ATA Statement Thyroid,2005,15: 77-79. Ladenson, PW. ATA guidelines Arch Intern Med, 2000,160:1573-1575. J Clin Endocrin Metab. 2007 低基础代谢率症群 怕冷、少汗及体温低于正常。易疲乏，行动迟缓，嗜睡，记忆力减退，反应迟钝，注意力不集中。 粘液性水肿面容 面部表情可以形容为"淡漠"，"假面具样"，"呆板"。面色苍白或蜡黄，面颊及眼睑虚肿，目光呆滞。鼻、唇增厚。舌大而发音不清，言语缓慢，音调低哑。头发干燥，稀疏，脆细，眉毛外1/3脱落，男性胡须生长缓慢。 皮肤 因轻度贫血而苍白或因甲状腺激素缺乏导致高胡萝卜素血症，病人手脚皮肤呈姜黄色。全身皮肤干燥、粗糙、少光泽、易脱屑。水肿为非凹陷性，以颜面和下肢为主。指甲生长缓慢，厚脆，表面常有裂纹。腋毛和阴毛稀疏脱落。 精神神经系统 反应迟钝，嗜睡，理解力和记忆力减退。有时可呈神经质，抑郁、失眠。可有手足麻木，痛觉异常。腱反射变化具有特征性，反射的收缩期往往敏捷，而松弛期延缓，跟腱反射减退，大于350毫微秒有利于诊断(正常为240-320ms)。膝反射多正常。 肌肉和关节 肌肉松弛无力，主要累及肩、背部肌肉，常感肌肉疼痛、僵硬。关节也常疼痛，活动不灵，有强直感，受冷后加重。发育期间骨龄常延迟。骨质代谢缓慢，骨形成与吸收均减少。 心血管系统 脉搏缓慢，心动过缓，心音低弱，心输出量减低。由于心肌间质水肿、非特异性心肌纤维肿胀、左心室扩张和心包积液导致心脏增大。心包积液，经治疗后可恢复正常。10%患者伴有血压增高。久病者易并发动脉粥样硬化。冠心病发病率高于一般人群，由于组织耗氧量和心输出量的减低相平行，故心肌耗氧量减少，很少发生心绞痛和心力衰竭。心力衰竭，一旦发生，因洋地黄在体内的半衰期延长，且由于心肌有粘液性水肿故常常疗效不佳且易发生洋地黄中毒。心绞痛在经左甲状腺素治疗后可加重。ECG显示低电压，T波倒置，QRS波增宽，P－R间期延长，个别患者可出现心肌梗塞的心电图表现。SGOT、LDH及CPK可增高，经治疗后均可消失。心肌纤维肿胀，有PAS染色阳性的粘液性糖蛋白沉积以及间质纤维化，称甲减性心肌病变。 * 孕妇甲状腺功能筛查及干预 在既往无甲状腺疾病的孕妇中，筛查孕妇合并的甲状腺疾病 临床及亚临床甲减 低甲状腺素血症 临床及亚临床甲亢 TPOAb阳性孕妇出现甲状腺功能异常的患病率增加 是否需要干预治疗？ 吴艺捷，等。待发表资料。 * 孕妇甲状腺功能筛查及干预 Yijie Wu, et al. 5th Huaxia Congress of Endocrinology，2008: Taipei, p49. * 孕妇甲状腺功能筛查及干预 Yijie Wu, et al. 5th Huaxia Congress of Endocrinology，2008: Taipei, p49. * 孕妇甲状腺功能筛查及干预 甲功异常中，SCH最常见，构成比为36.19% Yijie Wu, et al. 5th Huaxia Congress of Endocrinology，2008: Taipei, p49. * 孕妇甲状腺功能筛查及干预 TPOAb阳性孕妇，甲状腺功能异常的比率增加 * * P<0.01 Yijie Wu, et al. 5th Huaxia Congress of Endocrinology，2008: Taipei, p49. Chart4 28.75 20.56 TPOAb+ TPOAb- % Sheet1 2032 58 71 TPOAB阳性比例 315 2133 0.1476793249 328 2192 0.1496350365 351 2196 0.1598360656 312 2030 0.1536945813 325 2088 0.155651341 348 2092 0.1663479924 364 2255 0.1614190687 361 2150 0.1679069767 Euthyroid TPOAb+ 223 10.99% 33.48% Overt hypothyroidism 47 2.32% 7.21% subclinical hypothyroidism 241 11.87% 36.04% Overt hyperthyroidism 4 0.20% 0.60% subclinical hyperthyroidism 22 1.08% 3.30% hypothyroxinemia 129 6.35% 19.37% total 666 100.00% 表2 孕妇甲状腺功能异常666例各疾病治疗情况 甲状腺功能情况 总例数 未治疗 治疗 甲功正常TPOAB阳性 223 205 18 8.07% 临床甲减 47 38 9 19.15% 亚临床甲减 241 215 26 10.79% 临床甲亢 4 4 0 0.00% 亚甲亢 22 22 0 0.00% 低甲状腺素血症 129 123 6 4.65% 表3 所研究的2030孕妇妊娠期TPOAb阳性率 control group 14.05% 甲状腺功能异常分类 例数 TPOAb阳性例数 阳性率 thytoid dysfunction 20.32% 甲功正常 1587 223 14.05% total 15.42% 甲功异常 443 90 20.32% 孕妇群体 2030 313 15.42% groups 临床甲减 47 12 25.53% control group 14.05% 亚临床甲减 241 58 24.07% 临床甲亢 4 1 25.00% overt hypothyroidism 25.53% 亚甲亢 22 5 22.73% subclinical hypothyroidism 24.07% 低甲状腺素血症 129 14 10.85% overt hyperthyroidism 25.00% subclinical hyperthyroidism 22.73% hypothyroxinemia 10.85% 无既往史孕妇群体 2030 313 15.42% 仅包括既往自身免疫性疾病史 2089 326 15.61% 仅包括既往甲状腺疾病史 2097 353 16.83% 无既往史 15.42% 包括既往史阳性孕妇群体 2156 366 16.98% 包括既往自身免疫性疾病史 15.61% 包括既往甲状腺疾病史 16.83% 包括既往史阳性 16.98% 3 4 2 6 10 18 5 甲功分类 TPOAb阳性 TPOAb阴性 合计 total （例） 甲功正常 223 1364 1587 Prevalence of thyroid dysfunction 28.75% 20.56% 21.82% 甲功异常 90 353 443 合计 313 1717 2030 甲功异常患病率 28.75% 20.56% 21.82% Sheet1 0 0 0 Sheet2 0 0 0 0 0 0 Sheet3 0 0 0 TPOAb+% positive rate of TPOAb group Sheet4 0 0 0 0 0 0 0 TPOAb阳性率 分组 % 腹围 0 0 0 0 无既往史 包括既往自身免疫性疾病史 包括既往甲状腺疾病史 包括既往史阳性 不同群体孕妇甲状腺过氧化物酶抗体阳性率 双顶径 0 0 0 Prevalence of thyroid dysfunction group % 股骨 0 0 0 0 0 0 control group overt hypothyroidism subclinical hypothyroidism overt hyperthyroidism subclinical hyperthyroidism hypothyroxinemia group TPOAb+% 0 0 0 0 0 0 control group overt hypothyroidism subclinical hypothyroidism overt hyperthyroidism subclinical hyperthyroidism hypothyroxinemia TPOAb+% 223 47 241 4 22 129 0 0 0 0 0 0 control group overt hypothyroidism subclinical hypothyroidism overt hyperthyroidism subclinical hyperthyroidism hypothyroxinemia TPOAb+% 14.05 25.53 无既往史 2030 313 1717 包括既往自身免疫性疾病史阳性 2089 326 1763 包括既往甲状腺疾病史阳性 2097 353 1744 包括既往史阳性 2156 366 1790 甲状腺功能异常分类 例数 TPOAb阳性例数 TPOAb阴性例数 TPOAb阳性率 TPOAb阳性率 临床甲减 47 12 35 0.2553191489 临床甲减 25.53% 亚临床甲减 241 58 183 0.2406639004 亚临床甲减 24.07% 临床甲亢 4 1 3 0.25 临床甲亢 25.00% 亚甲亢 22 5 17 0.2272727273 亚甲亢 22.73% 低甲状腺素血症 129 14 115 0.1085271318 低甲状腺素血症 10.85% 甲功异常 443 90 353 0.2031602709 甲功异常 20.32% 甲功异常 25 22 3 0.88 0.12 2131 792 1339 0.3716564993 0.6283435007 甲状腺既往史 25 7 18 0.28 0.72 2131 60 2071 0.0281557954 0.9718442046 抗体阳性 25 16 9 0.64 0.36 2131 336 1795 0.1576724542 0.8423275458 甲功异常 甲功正常 甲状腺既往史阳性 甲状腺既往史阴性 TPOAB阳性 TPOAB阴性 甲状腺家族史阳性 88.00% 12.00% 28.00% 72.00% 64.00% 36.00% 甲状腺家族史阴性 37.17% 62.83% 2.82% 97.18% 15.77% 84.23% 异常孕妇群体分类 总例数 排除既往史阳性 排除家族史与既往史 甲功正常TPOAB阳性 248 223 201 81.05% 201(81.0483870967742%) euthyroid TPOAb+ 81.0500 18.9500 临床甲减 59 47 44 74.58% 44(74.5762711864407%) overt hypothyroidism 74.5800 25.4200 亚临床甲减 255 241 222 87.06% 222(87.0588235294118%) subclinical hypothyroidism 87.0600 12.9400 临床甲亢 21 4 4 19.05% 4(19.047619047619%) overt hyperthyroidism 19.0500 80.9500 亚甲亢 23 22 22 95.65% 22(95.6521739130435%) subclinical hyperthyroidism 95.6500 4.3500 低甲状腺素血症 137 129 125 91.24% 125(91.2408759124088%) hypothyroxinemia 91.2400 8.7600 total 83.1800 16.8200 表1-4 既往史和家族史阴性孕妇经甲状腺筛查发现的甲状腺疾病百分比 异常孕妇群体分类 总例数 既往史或家族史阳性 既往史和家族史均阴性 既往史和家族史均阴性 euthyroid TPOAb+ 248 47 201(81.05%) 0.8105 0.1895 overt hypothyroidism 59 15 44(74.58%) 0.7458 0.2542 subclinical hypothyroidism 255 33 222(87.06%) 0.8706 0.1294 overt hyperthyroidism 21 17 4(19.05%) 0.1905 0.8095 subclinical hyperthyroidism 23 1 22(95.65%) 0.9565 0.0435 hypothyroxinemia 137 12 125(91.24%) 0.9124 0.0876 FT3 in untreated group FT3 in treated group control -0.01837 euthyroid TPOAb+ -0.04836 -0.00372 overt hypothyroidism 0.05042 0.4278 subclinical hypothyroidism 0.0339 -0.10341 hypothyroxinemia 0.20865 0.185229 FT4 in untreated group FT4 in treated group control -0.02822 euthyroid TPOAb+ -0.07063 0.009342 overt hypothyroidism 0.17588 0.30181 subclinical hypothyroidism -0.0174 -0.00901 hypothyroxinemia 0.4314 0.5448 TSH in untreated group TSH in treated group control 0.157655 euthyroid TPOAb+ 0.424253 -0.38599 overt hypothyroidism 0.571869 -0.32195 subclinical hypothyroidism 0.6118 -0.25766 hypothyroxinemia 0.73138 0.081295 表4-4甲状腺疾病治疗组和未治疗组FT3、FT4、TSH、TPOAb妊娠中期与晚期相比较的P值 FT3 FT4 TSH TPOAb 正常对照组 ↘ 0 ↘ 0 ↗ 0.244 ↗ 0.653 ↘ 0 ↘ 0 ↘ 0.1 ↘ 0.062 ↘ 0.928 ↘ 0.958 ↘ 0.001 ↘ 0.001 临床甲减未治疗组 ↘ 0.304 ↗ 0.034 ↘ 0.151 临床甲减治疗组 ↗ 0.437 ↗ 0.005 ↘ 0.173 亚临床甲减未治疗组 ↘ 0.414 ↘ 0.014 ↗ 0 亚临床甲减治疗组 ↘ 0.026 ↘ 0.976 ↘ 0.001 低甲状腺素血症未治疗组 ↗ 0.099 ↗ 0 ↗ 0.066 低甲状腺素血症治疗组 ↗ 0.873 ↗ 0.347 ↗ 0.195 有2次化验 FT3 FT4 TSH TPOAb 正常对照组 -1.84% -1.84 -2.82% -2.82 53.71% 53.71 -4.84% -4.84 -7.06% -7.06 42.43% 42.43 -0.37% -0.37 0.93% 0.93 -38.60% -38.60 临床甲减未治疗组 5.04% 5.04 17.59% 17.59 57.19% 57.19 临床甲减治疗组 42.78% 42.78 30.18% 30.18 -32.20% -32.20 亚临床甲减未治疗组 3.39% 3.39 -1.74% -1.74 130.06% 130.06 亚临床甲减治疗组 -10.34% -10.34 -0.90% -0.90 -25.77% -25.77 低甲状腺素血症未治疗组 20.87% 20.87 43.14% 43.14 73.14% 73.14 低甲状腺素血症治疗组 18.52% 18.52 54.48% 54.48 8.13% 8.13 FT3 in untreated group FT3 in treated group FT4 in untreated group FT4 in treated group TSH in untreated group TSH in treated group control -0.01837 -0.02822 0.537057 euthyroid TPOAb+ -0.04836 -0.00372 -0.07063 0.009342 0.424253 -0.38599 overt hypothyroidism 0.05042 0.4278 0.17588 0.30181 0.571869 -0.32195 subclinical hypothyroidism 0.0339 -0.10341 -0.0174 -0.00901 1.3006 -0.25766 hypothyroxinemia 0.20865 0.185229 0.4314 0.5448 0.73138 0.081295 分组 例数 年龄 分娩孕周 新生儿体重 1’评分 5’评分 正常对照组 1017 28.5±4.2 38.8±1.8 3280.6±454.5 9.46±0.7 9.66±0.6 153 38.8±1.6 3273.3±483.6 12 27.6±2.9 38.4±1.5 3086.3±322.7 9.67±0.5 9.83±0.4 临床甲减未治疗组 29 27.0±3.2 39.2±1.3 3186.4±354.9 9.46±0.5 9.64±0.5 临床甲减治疗组 6 29.3±4.8 39.6±1.0 3222.5±274.8 9.5±0.5 9.50±0.5 亚临床甲减未治疗组 166 28.3±4.2 亚临床甲减治疗组 16 27.4±3.6 39.3±0.9 3267.8±475.9 9.31±0.5 9.37±0.5 低甲状腺素血症未治疗组 88 29.4±4.2 38.7±1.4 3304.9±453.5 9.38±0.6 9.57±0.6 低甲状腺素血症治疗组 5 27.0±5.1 40.2±0.7 3384.0±403.2 9.40±0.5 9.40±0.5 临床甲亢 1 31 39.1 2700 9 9 亚临床甲亢未治疗组 10 28.5±2.6 39.1±1.3 3338.0±378.4 9.50±0.5 9.60±0.5 分组 例数 年龄 分娩孕周 新生儿体重 1’评分 5’评分 Apgar 1 minute's grade in untreated groups Apgar 1 minute's grade in treated groups 正常对照组 1017 28.5±4.2 38.8±1.8 3280.6±454.5 9.46±0.7 9.66±0.6 control 9.46 153 38.8±1.6 3273.3±483.6 euthyroid TPOAb+ 9.3 9.67 12 27.6±2.9 38.4±1.5 3086.3±322.7 9.67±0.5 9.83±0.4 overt hypothyroidism 9.46 9.5 临床甲减未治疗组 29 27.0±3.2 39.2±1.3 3186.4±354.9 9.46±0.5 9.64±0.5 subclinical hypothyroidism 9.24 9.31 临床甲减治疗组 6 29.3±4.8 39.6±1.0 3222.5±274.8 9.5±0.5 9.50±0.5 hypothyroxinemia 9.38 9.4 亚临床甲减未治疗组 166 28.3±4.2 亚临床甲减治疗组 16 27.4±3.6 39.3±0.9 3267.8±475.9 9.31±0.5 9.37±0.5 Apgar 5 minute's grade in untreated groups Apgar 5 minute's grade in treated groups 低甲状腺素血症未治疗组 88 29.4±4.2 38.7±1.4 3304.9±453.5 9.38±0.6 9.57±0.6 control 9.66 低甲状腺素血症治疗组 5 27.0±5.1 40.2±0.7 3384.0±403.2 9.40±0.5 9.40±0.5 euthyroid TPOAb+ 9.48 9.83 临床甲亢 1 31 39.1 2700 9 9 overt hypothyroidism 9.64 9.5 亚临床甲亢未治疗组 10 28.5±2.6 39.1±1.3 3338.0±378.4 9.50±0.5 9.60±0.5 subclinical hypothyroidism 9.55 9.37 hypothyroxinemia 9.57 9.4 incidence of untreated groups incidence of treated groups control 49.1 euthyroid TPOAb+ 66.7 58.3 overt hypothyroidism 51.7 16.7 subclinical hypothyroidism 55.4 37.5 hypothyroxinemia 70.5 40 胎窘 胎儿宫内发育迟缓 早产 胎膜早破 糖代谢异常 妊娠期高血压疾病 新生儿畸形 新生儿肺炎 死胎、围产儿死亡 合计 组 例 0 752 158 594 1 112 44 68 11 10 5 5 5 22 7 15 55 5 0 5 2 117 25 92 22 12 2 10 4 62 23 39 44 4 1 3 FT3 in untreated group FT3 in treated group control -1.837 -0.01837 euthyroid TPOAb+ -4.836 -0.372 -0.04836 -0.00372 overt hypothyroidism 5.042 42.78 0.05042 0.4278 subclinical hypothyroidism 3.39 -10.341 0.0339 -0.10341 hypothyroxinemia 20.865 18.5229 0.20865 0.185229 FT4 in untreated group FT4 in treated group control -2.822 -0.02822 euthyroid TPOAb+ -7.063 0.9342 -0.07063 0.009342 overt hypothyroidism 17.588 30.181 0.17588 0.30181 subclinical hypothyroidism -1.74 -0.901 -0.0174 -0.00901 hypothyroxinemia 43.14 54.48 0.4314 0.5448 TSH in untreated group TSH in treated group control 15.7655 0.157655 euthyroid TPOAb+ 42.4253 -38.599 0.424253 -0.38599 overt hypothyroidism 57.1869 -32.195 0.571869 -0.32195 subclinical hypothyroidism 61.18 -25.766 0.6118 -0.25766 hypothyroxinemia 73.138 8.1295 0.73138 0.081295 by thyroid screening by personal or family history groups percentage FT3 in untreated group FT3 in treated group groups percentage 0 0 0 0 0 0 0 0 0 0 FT4 in untreated group FT4 in treated group groups percentage 0 0 0 0 0 0 0 0 0 0 TSH in untreated group TSH in treated group groups percentage 0 0 0 0 0 0 0 0 0 0 TSH in untreated group TSH in treated group groups percentage 0 0 0 0 0 0 0 0 0 0 Apgar 1 minute's grade in untreated groups Apgar 1 minute's grade in treated groups groups score 0 0 0 0 0 0 0 0 0 0 Apgar 5 minute's grade in untreated groups Apgar 5 minute's grade in treated groups groups score 0 0 0 0 0 0 0 0 0 0 incidence of untreated groups incidence of treated groups groups % 0 0 0 0 0 0 0 0 0 0 incidence of untreated groups incidence of treated groups groups % by thyroid screening by personal or family history groups % 0 0 0 0 0 0 0 0 0 0 FT3 in untreated group FT3 in treated group groups % 0 0 0 0 0 0 0 0 0 0 FT4 in untreated group FT4 in treated group groups % 0 0 0 0 0 0 0 0 0 0 TSH in untreated group TSH in treated group groups % 临床甲减 亚临床甲减 临床甲亢 亚甲亢 低甲状腺素血症 表4-3妊娠中晚期FT3、FT4、TSH平均水平 FT3 (pmol/L) FT4 (pmol/L) TSH (mIU/L) TPOAb (IU/mL) 例 妊娠中期 妊娠晚期 妊娠中期 妊娠晚期 妊娠中期 妊娠晚期 妊娠中期 妊娠晚期 正常对照组 1364 3.22 3.1 14.18 13.57 2.03 2.1 7.01 7.12 205 3.22 3.05 14.14 13.21 2.04 1.87 221.65 137.14 18 3.15 3.14 13.9 13.87 2.37 1.48 903.33 320.93 临床甲减未治疗组 38 2.91 2.76 10.59 11.78 5.43 4.65 158.17 112.83 临床甲减治疗组 9 2.73 2.94 10.96 13.85 4.81 3.83 341.73 356.24 亚临床甲减未治疗组 215 3.14 3.09 13.66 13.09 4.05 5.37 59.87 66.92 亚临床甲减治疗组 26 3.09 2.86 13.21 13.2 5.11 3.68 457.81 204.12 低甲状腺素血症未治疗组 123 2.79 2.92 10.63 12.16 1.86 2.12 18.31 13.96 低甲状腺素血症治疗组 6 2.67 2.71 10.87 12.01 1.44 1.92 255.07 121.76 临床甲亢未治疗组 4 5.47 3.59 22.12 18.02 0.37 0.9 18.31 5.543 亚临床甲亢未治疗组 22 . 3.06 14.9 14.27 0.28 0.27 8.21 10.93 表4-3妊娠中晚期FT3、FT4、TSH平均水平 FT3 (pmol/L) FT4 (pmol/L) TSH (mIU/L) TPOAb (IU/mL) 例 妊娠中期 妊娠晚期 妊娠中期 妊娠中期 妊娠晚期 妊娠晚期 妊娠中期 妊娠晚期 正常对照组 1364 3.22±0.43 3.10±0.41 14.18±2.12 13.57±1.95 2.03±0.97 2.10±0.99 7.01±4.00 7.12±4.01 205 3.22±0.45 3.05±0.37 13.21±1.91 18 3.15±0.36 3.14±0.44 13.90±1.91 13.87±2.22 临床甲减未治疗组 38 158.17±534.51 112.83±400.68 临床甲减治疗组 9 2.94±0.58 13.85±2.71 356.24±580.25 亚临床甲减未治疗组 215 3.09±0.73 亚临床甲减治疗组 26 13.20±1.76 低甲状腺素血症未治疗组 123 18.31±88.42 低甲状腺素血症治疗组 6 255.07±341.61 121.76±322.92 临床甲亢未治疗组 4 5.47±1.57 18.02±5.64 18.31±88.42 5.543±6.01 亚临床甲亢未治疗组 22 . 3.06±0.39 14.27±2.74 8.21±5.50 10.93±7.58 control group 14.05% thytoid dysfunction 20.32% total 15.42% TPOAb+ TPOAb- total groups 28.75 20.56 21.82 controls thytoid dysfunction total groups 14.05 20.32 15.42 ﹡ ﹡ 0 0 0 TPOAb+ TPOAb- total % controls thytoid dysfunction total % 0 0 0 TPOAb+ TPOAb- total % TPOAb+ TPOAb- total % TPOAb+ TPOAb- total % TPOAb+ TPOAb- % TPOAb+ TPOAb- % 正常对照 TSH 分期 分期 0 3.74 1 S1 0 1.81 1 S1 0 3.82 1 S1 0 3.05 1 S1 0 2.59 1 S1 0 2.54 1 S1 0 0.36 1 S1 0 2.66 1 S1 0 0.81 1 S1 0 2.09 1 S1 0 1.9 1 S1 0 0.25 1 S1 0 1.61 1 S1 0 1.44 1 S1 0 2.48 2 S2 0 0.86 2 S2 0 1.57 2 S2 0 1.76 2 S2 0 1.23 2 S2 0 0.62 2 S2 0 1.71 2 S2 0 1.56 2 S2 0 0.4 2 S2 0 2.02 2 S2 0 1.4 2 S2 0 1.35 2 S2 0 1.74 2 S2 0 1.27 2 S2 0 2.45 2 S2 0 2.57 2 S2 0 1.85 2 S2 0 3.85 2 S2 0 0.8 2 S2 0 1.88 2 S2 0 0.3 2 S2 0 2.57 2 S2 0 3.66 2 S2 0 1.98 2 S2 0 0.58 2 S2 0 0.26 2 S2 0 2.32 2 S2 0 2.3 2 S2 0 1.71 2 S2 0 1.76 2 S2 0 1.51 2 S2 0 0.45 2 S2 0 0.86 2 S2 0 2.02 2 S2 0 1.66 2 S2 0 3.89 2 S2 0 2.46 2 S2 0 1.17 2 S2 0 2.76 2 S2 0 1.49 2 S2 0 2.74 2 S2 0 1.75 2 S2 0 1.77 2 S2 0 0.29 2 S2 0 2.14 2 S2 0 0.98 2 S2 0 0.98 2 S2 0 0.26 2 S2 0 2.8 2 S2 0 1.4 2 S2 0 3.37 2 S2 0 1.23 2 S2 0 2.07 2 S2 0 1.92 2 S2 0 0.47 2 S2 0 0.44 2 S2 0 2.21 2 S2 0 0.85 2 S2 0 0.78 2 S2 0 1.38 2 S2 0 0.92 2 S2 0 2.12 2 S2 0 3.34 2 S2 0 3.33 2 S2 0 2.81 2 S2 0 2.41 2 S2 0 3.43 2 S2 0 3.68 2 S2 0 2.1 2 S2 0 2.07 2 S2 0 1.43 2 S2 0 3.99 2 S2 0 1.82 2 S2 0 2.62 2 S2 0 2.95 2 S2 0 2.36 2 S2 0 0.74 2 S2 0 1.1 2 S2 0 1.34 2 S2 0 0.99 2 S2 0 1.79 2 S2 0 1.81 2 S2 0 1.59 2 S2 0 2.92 2 S2 0 1.84 2 S2 0 0.81 2 S2 0 3.43 2 S2 0 2.44 2 S2 0 0.81 2 S2 0 2.11 2 S2 0 1.28 2 S2 0 0.39 2 S2 0 2 2 S2 0 1.21 2 S2 0 0.49 2 S2 0 0.8 2 S2 0 1.63 2 S2 0 1.68 2 S2 0 3 2 S2 0 1.06 2 S2 0 0.25 2 S2 0 0.7 2 S2 0 2.43 2 S2 0 1.12 2 S2 0 3.64 2 S2 0 1.44 2 S2 0 2.22 2 S2 0 2.29 2 S2 0 1.13 2 S2 0 1.77 2 S2 0 3.25 2 S2 0 3.02 2 S2 0 1.69 2 S2 0 2.5 2 S2 0 3.23 2 S2 0 0.86 2 S2 0 1.52 2 S2 0 1.92 2 S2 0 2.51 2 S2 0 2.7 2 S2 0 1.39 2 S2 0 2.16 2 S2 0 1.11 2 S2 0 3.79 2 S2 0 3.24 2 S2 0 0.54 2 S2 0 0.69 2 S2 0 1.45 2 S2 0 1.97 2 S2 0 0.89 2 S2 0 1.9 2 S2 0 1.85 2 S2 0 2.52 2 S2 0 0.25 2 S2 0 1.57 2 S2 0 3.28 2 S2 0 3.91 2 S2 0 1.86 2 S2 0 3.84 2 S2 0 1.75 2 S2 0 3.12 2 S2 0 1.36 2 S2 0 2.66 2 S2 0 2.34 2 S2 0 1.46 2 S2 0 3.25 2 S2 0 1.56 2 S2 0 3.56 2 S2 0 3.87 2 S2 0 2.06 2 S2 0 2.8 2 S2 0 3.09 2 S2 0 2.18 2 S2 0 3.32 2 S2 0 2.12 2 S2 0 3.16 2 S2 0 3.47 2 S2 0 2.7 2 S2 0 1.78 2 S2 0 1.11 2 S2 0 2.42 2 S2 0 3.25 2 S2 0 1.44 2 S2 0 0.9 2 S2 0 0.26 2 S2 0 2.36 2 S2 0 1.06 2 S2 0 1.01 2 S2 0 1.12 2 S2 0 3.14 2 S2 0 3.9 2 S2 0 2.32 2 S2 0 1.68 2 S2 0 2.45 2 S2 0 1.67 2 S2 0 3.62 2 S2 0 1.7 2 S2 0 3.4 2 S2 0 3.07 2 S2 0 2.8 2 S2 0 1.41 2 S2 0 3.42 2 S2 0 2.69 2 S2 0 2.48 2 S2 0 2.29 2 S2 0 1.22 2 S2 0 2.34 2 S2 0 2.83 2 S2 0 1.3 2 S2 0 1.02 2 S2 0 1.16 2 S2 0 3.12 2 S2 0 3.99 2 S2 0 1.37 2 S2 0 3.38 2 S2 0 0.43 2 S2 0 2.45 2 S2 0 2.01 2 S2 0 1.89 2 S2 0 1.7 2 S2 0 1.47 2 S2 0 0.96 2 S2 0 2.9 2 S2 0 0.44 2 S2 0 3.16 2 S2 0 3.97 2 S2 0 2.66 2 S2 0 1.49 2 S2 0 0.86 2 S2 0 2.13 2 S2 0 1.25 2 S2 0 1.96 2 S2 0 0.77 2 S2 0 1.05 2 S2 0 3.39 2 S2 0 0.26 2 S2 0 2.27 2 S2 0 3.55 2 S2 0 1.2 2 S2 0 2.94 2 S2 0 1.13 2 S2 0 1.86 2 S2 0 0.52 2 S2 0 1.12 2 S2 0 2.53 2 S2 0 0.8 2 S2 0 1.33 2 S2 0 0.8 2 S2 0 2.65 2 S2 0 2.01 2 S2 0 1.64 2 S2 0 2.25 2 S2 0 1.48 2 S2 0 1.37 2 S2 0 3.43 2 S2 0 2.97 2 S2 0 1.91 2 S2 0 1.84 2 S2 0 0.57 2 S2 0 0.97 2 S2 0 1.74 2 S2 0 2.33 2 S2 0 3.11 2 S2 0 1.47 2 S2 0 1.94 2 S2 0 1.72 2 S2 0 3.72 2 S2 0 0.26 2 S2 0 1.65 2 S2 0 1.15 2 S2 0 1.67 2 S2 0 1.18 2 S2 0 0.81 2 S2 0 0.99 2 S2 0 2.84 2 S2 0 1.76 2 S2 0 2.78 2 S2 0 3.73 2 S2 0 1.62 2 S2 0 3.35 2 S2 0 1.94 2 S2 0 0.26 2 S2 0 2.18 2 S2 0 2.48 2 S2 0 1.66 2 S2 0 1.33 2 S2 0 1.52 2 S2 0 1.79 2 S2 0 2.75 2 S2 0 3.45 2 S2 0 2.04 2 S2 0 2.56 2 S2 0 3.44 2 S2 0 3.75 2 S2 0 3.29 2 S2 0 1.64 2 S2 0 1.25 2 S2 0 2.54 2 S2 0 2.86 2 S2 0 1.84 2 S2 0 3.8 2 S2 0 0.64 2 S2 0 2.52 2 S2 0 1.09 2 S2 0 2.59 2 S2 0 2.46 2 S2 0 3.25 2 S2 0 2.11 2 S2 0 3.56 2 S2 0 0.26 2 S2 0 3.02 2 S2 0 2.48 2 S2 0 3.82 2 S2 0 2.27 2 S2 0 1.87 2 S2 0 1.27 2 S2 0 0.49 2 S2 0 2.05 2 S2 0 1.78 2 S2 0 3.65 2 S2 0 3.86 2 S2 0 1.28 2 S2 0 3 2 S2 0 2.67 2 S2 0 3.14 2 S2 0 2.26 2 S2 0 1.19 2 S2 0 3.94 2 S2 0 0.89 2 S2 0 1.87 2 S2 0 3.28 2 S2 0 1.22 2 S2 0 3.9 2 S2 0 2.25 2 S2 0 1.75 2 S2 0 1.55 2 S2 0 1.46 2 S2 0 1.57 2 S2 0 3.25 2 S2 0 0.53 2 S2 0 2 2 S2 0 1.11 2 S2 0 3.13 2 S2 0 0.91 2 S2 0 3.52 2 S2 0 1.99 2 S2 0 2.16 2 S2 0 1.7 2 S2 0 1.39 2 S2 0 2.41 2 S2 0 0.82 2 S2 0 3.65 2 S2 0 0.73 2 S2 0 0.25 2 S2 0 3.94 2 S2 0 0.34 2 S2 0 0.43 2 S2 0 0.79 2 S2 0 0.84 2 S2 0 1.07 2 S2 0 2.16 2 S2 0 1.79 2 S2 0 2.09 2 S2 0 0.84 2 S2 0 1.23 2 S2 0 1.23 2 S2 0 3.14 2 S2 0 1.17 2 S2 0 1.3 2 S2 0 3.37 2 S2 0 3.5 2 S2 0 0.25 2 S2 0 1.34 2 S2 0 1.78 2 S2 0 1.23 2 S2 0 2.26 2 S2 0 2.85 2 S2 0 3.62 2 S2 0 1.32 2 S2 0 2.39 2 S2 0 1.03 2 S2 0 1.53 2 S2 0 2.87 2 S2 0 1.45 2 S2 0 1.22 2 S2 0 1.26 2 S2 0 3.87 2 S2 0 2.29 2 S2 0 2.01 2 S2 0 2.18 2 S2 0 1.86 2 S2 0 3.31 2 S2 0 1.58 2 S2 0 2.13 2 S2 0 1.47 2 S2 0 2.07 2 S2 0 0.39 2 S2 0 0.72 2 S2 0 2.09 2 S2 0 2.14 2 S2 0 1.02 2 S2 0 1.66 2 S2 0 1.82 2 S2 0 2.54 2 S2 0 3.13 2 S2 0 2.66 2 S2 0 3.92 2 S2 0 2.07 2 S2 0 0.25 2 S2 0 1.31 2 S2 0 1.17 2 S2 0 3.71 2 S2 0 2.26 2 S2 0 1.98 2 S2 0 2.06 2 S2 0 1.51 2 S2 0 2.98 2 S2 0 1.92 2 S2 0 1.94 2 S2 0 1.42 2 S2 0 1.83 2 S2 0 0.93 2 S2 0 1.38 2 S2 0 3.15 2 S2 0 1.58 2 S2 0 3.31 2 S2 0 1.15 2 S2 0 0.25 2 S2 0 1.61 2 S2 0 0.92 2 S2 0 3.42 2 S2 0 0.91 2 S2 0 2 2 S2 0 2.07 2 S2 0 2.64 2 S2 0 3.79 2 S2 0 2.4 2 S2 0 3.25 2 S2 0 2.94 2 S2 0 1.23 2 S2 0 2.41 2 S2 0 1.9 2 S2 0 3.87 2 S2 0 1.17 2 S2 0 2.86 2 S2 0 2.49 2 S2 0 0.79 2 S2 0 2.43 2 S2 0 2.98 2 S2 0 0.25 2 S2 0 1.16 2 S2 0 2.89 2 S2 0 2.78 2 S2 0 2.11 2 S2 0 2.79 2 S2 0 1.7 2 S2 0 3.15 2 S2 0 3.36 2 S2 0 0.93 2 S2 0 3.1 2 S2 0 3 2 S2 0 1.94 2 S2 0 2.22 2 S2 0 1.55 2 S2 0 2.36 2 S2 0 1.52 2 S2 0 3.86 2 S2 0 2.79 2 S2 0 2.2 2 S2 0 2.34 2 S2 0 2.44 2 S2 0 2.36 2 S2 0 2.64 2 S2 0 3.13 2 S2 0 3.98 2 S2 0 2.03 2 S2 0 2.58 2 S2 0 0.84 2 S2 0 0.26 2 S2 0 0.99 2 S2 0 0.64 2 S2 0 1.65 2 S2 0 3.63 2 S2 0 2.4 2 S2 0 0.4 2 S2 0 2.11 2 S2 0 3.59 2 S2 0 2.29 2 S2 0 0.65 2 S2 0 1.17 2 S2 0 2.32 2 S2 0 0.96 2 S2 0 3.19 2 S2 0 2.26 2 S2 0 1.39 2 S2 0 2.8 2 S2 0 1.06 2 S2 0 2.11 2 S2 0 3.16 2 S2 0 1.44 2 S2 0 1.79 2 S2 0 2.15 2 S2 0 1.28 2 S2 0 1.05 2 S2 0 2.43 2 S2 0 1.12 2 S2 0 1.77 2 S2 0 2.56 2 S2 0 1.61 2 S2 0 1.61 2 S2 0 0.65 2 S2 0 1.35 2 S2 0 3.28 2 S2 0 3.27 2 S2 0 1.12 2 S2 0 2.1 2 S2 0 0.59 2 S2 0 2.13 2 S2 0 2.43 2 S2 0 2.94 2 S2 0 0.43 2 S2 0 1.76 2 S2 0 0.68 2 S2 0 1.87 2 S2 0 1.39 2 S2 0 0.66 2 S2 0 3.76 2 S2 0 1.2 2 S2 0 0.73 2 S2 0 0.9 2 S2 0 2.03 2 S2 0 2.78 2 S2 0 1.57 2 S2 0 1.32 2 S2 0 2.42 2 S2 0 0.88 2 S2 0 0.77 2 S2 0 1.35 2 S2 0 2.12 2 S2 0 2.81 2 S2 0 0.91 2 S2 0 1.44 2 S2 0 3.6 2 S2 0 3.75 2 S2 0 1.18 2 S2 0 0.63 2 S2 0 3.34 2 S2 0 0.99 2 S2 0 2.37 2 S2 0 1.02 2 S2 0 1.08 2 S2 0 3.08 2 S2 0 2.25 2 S2 0 1.89 2 S2 0 1.97 2 S2 0 1.09 2 S2 0 1.14 2 S2 0 2.44 2 S2 0 0.9 2 S2 0 3.45 2 S2 0 1.74 2 S2 0 1.05 2 S2 0 3.42 2 S2 0 3.32 2 S2 0 0.74 2 S2 0 2.37 2 S2 0 3.18 2 S2 0 2.99 2 S2 0 0.25 2 S2 0 1.04 2 S2 0 2.01 2 S2 0 3.15 2 S2 0 3.62 2 S2 0 1.5 2 S2 0 0.25 2 S2 0 3.08 2 S2 0 2.45 2 S2 0 2.82 2 S2 0 1.99 2 S2 0 1.86 2 S2 0 3.73 2 S2 0 3.77 2 S2 0 3.03 2 S2 0 2.57 2 S2 0 0.46 2 S2 0 1.52 2 S2 0 3.82 2 S2 0 2.2 2 S2 0 2.81 2 S2 0 3.89 2 S2 0 2.73 2 S2 0 2.63 2 S2 0 2.66 2 S2 0 1.33 2 S2 0 3.91 2 S2 0 2.63 2 S2 0 1.74 2 S2 0 2.95 2 S2 0 2.08 2 S2 0 1.25 2 S2 0 3.21 2 S2 0 1.6 2 S2 0 1.71 2 S2 0 3.34 2 S2 0 3.97 2 S2 0 2.96 2 S2 0 1.73 2 S2 0 2.66 2 S2 0 3.32 2 S2 0 1.75 2 S2 0 2.16 2 S2 0 1.14 2 S2 0 2.46 2 S2 0 1.5 2 S2 0 3.4 2 S2 0 2.05 2 S2 0 1.1 2 S2 0 3.41 2 S2 0 1.8 2 S2 0 1.82 2 S2 0 1.97 2 S2 0 0.8 2 S2 0 1.43 2 S2 0 1.3 2 S2 0 1.73 2 S2 0 2.39 2 S2 0 1.96 2 S2 0 2.6 2 S2 0 1.54 2 S2 0 0.7 2 S2 0 0.64 2 S2 0 3.53 2 S2 0 1.46 2 S2 0 0.99 2 S2 0 2.02 2 S2 0 1.81 2 S2 0 2.22 2 S2 0 1.47 2 S2 0 1.62 2 S2 0 1.71 2 S2 0 3.38 2 S2 0 1.05 2 S2 0 1.93 2 S2 0 1.28 2 S2 0 1.16 2 S2 0 0.71 2 S2 0 1.46 2 S2 0 0.75 2 S2 0 1.37 2 S2 0 2.31 2 S2 0 1.28 2 S2 0 2.13 2 S2 0 3.23 2 S2 0 1.05 2 S2 0 0.92 2 S2 0 3.53 2 S2 0 1.29 2 S2 0 2.1 2 S2 0 2.9 2 S2 0 2.03 2 S2 0 2.96 2 S2 0 2.58 2 S2 0 1.28 2 S2 0 3.31 2 S2 0 1.86 2 S2 0 1.64 2 S2 0 2.11 2 S2 0 2.95 2 S2 0 0.96 2 S2 0 1.66 2 S2 0 3.44 2 S2 0 2.92 2 S2 0 1.08 2 S2 0 2.05 2 S2 0 1.48 2 S2 0 1.29 2 S2 0 2.86 2 S2 0 1.19 2 S2 0 0.25 2 S2 0 0.59 2 S2 0 1.83 2 S2 0 3.46 2 S2 0 1.31 2 S2 0 2.69 2 S2 0 1.79 2 S2 0 2 2 S2 0 2.16 2 S2 0 1.69 2 S2 0 3.13 2 S2 0 1.76 2 S2 0 0.85 2 S2 0 1.67 2 S2 0 1.66 2 S2 0 1.49 2 S2 0 2.15 2 S2 0 1.61 2 S2 0 1.53 2 S2 0 1.06 2 S2 0 1.33 2 S2 0 2.32 2 S2 0 1.86 2 S2 0 1.97 2 S2 0 1.93 2 S2 0 2.1 2 S2 0 3.88 2 S2 0 1.06 2 S2 0 3.83 2 S2 0 3.87 2 S2 0 1.37 2 S2 0 2.14 2 S2 0 3.06 2 S2 0 3.96 2 S2 0 3.48 2 S2 0 3.08 2 S2 0 1.7 2 S2 0 2.18 2 S2 0 1.17 2 S2 0 1.66 2 S2 0 3.98 2 S2 0 0.51 2 S2 0 2.32 2 S2 0 1.44 2 S2 0 3.27 2 S2 0 1.1 2 S2 0 1.08 2 S2 0 2.28 2 S2 0 1.62 2 S2 0 2.03 2 S2 0 1.72 2 S2 0 1.4 2 S2 0 3.21 2 S2 0 1.98 2 S2 0 2.02 2 S2 0 2.64 2 S2 0 2.49 2 S2 0 1.11 2 S2 0 3.92 2 S2 0 3.84 2 S2 0 1.28 2 S2 0 1.41 2 S2 0 1.84 2 S2 0 2.44 2 S2 0 2.3 2 S2 0 1.17 2 S2 0 0.25 2 S2 0 2.32 2 S2 0 3.87 2 S2 0 0.93 2 S2 0 1.88 2 S2 0 0.42 2 S2 0 2.41 2 S2 0 2.21 2 S2 0 2.78 2 S2 0 1.3 2 S2 0 1.96 2 S2 0 3.35 2 S2 0 1.98 2 S2 0 3.14 2 S2 0 1.54 2 S2 0 1.33 2 S2 0 3.87 2 S2 0 3.22 2 S2 0 3.98 2 S2 0 2.17 2 S2 0 3.67 2 S2 0 0.91 2 S2 0 1.26 2 S2 0 2.6 2 S2 0 2.05 2 S2 0 3.9 2 S2 0 1.21 2 S2 0 1.68 2 S2 0 0.95 2 S2 0 3.47 2 S2 0 3.94 2 S2 0 3.37 2 S2 0 1.73 2 S2 0 1.15 2 S2 0 2.63 2 S2 0 3.86 2 S2 0 2.03 2 S2 0 1.36 2 S2 0 2.64 2 S2 0 1.23 2 S2 0 2.46 2 S2 0 1.78 2 S2 0 1.1 2 S2 0 2.18 2 S2 0 2.59 2 S2 0 0.51 2 S2 0 2.67 2 S2 0 1.96 2 S2 0 1.24 2 S2 0 1.04 2 S2 0 1.35 2 S2 0 3.45 2 S2 0 1.49 2 S2 0 3.57 2 S2 0 1.51 2 S2 0 3.18 2 S2 0 1.12 2 S2 0 1.38 2 S2 0 2.47 2 S2 0 2.44 2 S2 0 3.3 2 S2 0 1.75 2 S2 0 3.34 2 S2 0 2.09 2 S2 0 1.21 2 S2 0 2.2 2 S2 0 0.97 2 S2 0 2.05 2 S2 0 0.49 2 S2 0 3 2 S2 0 1.57 2 S2 0 2.77 2 S2 0 3.19 2 S2 0 3.02 2 S2 0 2.56 2 S2 0 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0 3.92 2 S2 0 1.43 2 S2 0 0.8 2 S2 0 1.13 2 S2 0 1.19 2 S2 0 1.71 2 S2 0 3.7 2 S2 0 0.49 2 S2 0 1.89 2 S2 0 0.98 2 S2 0 3.45 2 S2 0 3.75 2 S2 0 1.71 2 S2 0 2.94 2 S2 0 2.1 2 S2 0 1.67 2 S2 0 1.32 2 S2 0 1.54 2 S2 0 0.51 2 S2 0 2.86 2 S2 0 1.09 2 S2 0 3.4 2 S2 0 1.33 2 S2 0 1.47 2 S2 0 3.02 2 S2 0 3.2 2 S2 0 0.49 2 S2 0 2.61 3 S3 0 2.6 3 S3 0 0.9 3 S3 0 3.41 3 S3 0 3.75 3 S3 0 1.52 3 S3 0 1 3 S3 0 1.64 3 S3 0 2.01 3 S3 0 2.29 3 S3 0 1.55 3 S3 0 3.91 3 S3 0 1.58 3 S3 0 0.47 3 S3 0 1.02 3 S3 0 1.18 3 S3 0 1.5 3 S3 0 1.8 3 S3 0 0.46 3 S3 0 0.36 3 S3 0 1.26 3 S3 0 1.98 3 S3 0 2.9 3 S3 0 0.78 3 S3 0 2.61 3 S3 0 1.58 3 S3 0 1.2 3 S3 0 0.55 3 S3 0 2.54 3 S3 0 2.17 3 S3 0 2.43 3 S3 0 1.36 3 S3 0 3.22 3 S3 0 3.37 3 S3 0 2.74 3 S3 0 3.42 3 S3 0 2.6 3 S3 0 1.35 3 S3 0 3.24 3 S3 0 1.04 3 S3 0 1.64 3 S3 0 3.51 3 S3 0 1.76 3 S3 0 2.79 3 S3 0 1.15 3 S3 0 1.61 3 S3 0 2.05 3 S3 0 0.26 3 S3 0 3.78 3 S3 0 0.66 3 S3 0 1.93 3 S3 0 0.89 3 S3 0 1.58 3 S3 0 1.17 3 S3 0 2.12 3 S3 0 3.15 3 S3 0 0.32 3 S3 0 3.32 3 S3 0 2.13 3 S3 0 2.4 3 S3 0 0.84 3 S3 0 2.67 3 S3 0 2.55 3 S3 0 2.19 3 S3 0 2.93 3 S3 0 1.84 3 S3 0 0.64 3 S3 0 1.63 3 S3 0 1.9 3 S3 0 3.91 3 S3 0 1.1 3 S3 0 3.95 3 S3 0 1.94 3 S3 0 1.31 3 S3 0 0.82 3 S3 0 2.59 3 S3 0 1.75 3 S3 0 0.25 3 S3 0 1.57 3 S3 0 2.17 3 S3 0 0.39 3 S3 0 1.73 3 S3 0 1.32 3 S3 0 0.66 3 S3 0 0.96 3 S3 0 1.99 3 S3 0 0.48 3 S3 0 2.4 3 S3 0 3.59 3 S3 0 1.61 3 S3 0 2.42 3 S3 0 3.43 3 S3 0 2.49 3 S3 0 1.66 3 S3 0 1.84 3 S3 0 1.74 3 S3 0 0.82 3 S3 0 1.23 3 S3 0 3.8 3 S3 0 3.68 3 S3 0 3.51 3 S3 0 0.54 3 S3 0 3.93 3 S3 0 1.58 3 S3 0 3.91 3 S3 0 2.96 3 S3 0 2.63 3 S3 0 1.35 3 S3 0 1.35 3 S3 0 2.05 3 S3 0 0.71 3 S3 0 0.64 3 S3 0 2.9 3 S3 0 0.58 3 S3 0 1.9 3 S3 0 2.87 3 S3 0 0.56 3 S3 0 1.55 3 S3 0 2.15 3 S3 0 0.83 3 S3 0 2.52 3 S3 0 1.19 3 S3 0 3.97 3 S3 0 1.83 3 S3 0 2.65 3 S3 0 3.25 3 S3 0 1.68 3 S3 0 1.99 3 S3 0 1.39 3 S3 0 3.6 3 S3 0 0.92 3 S3 0 3.18 3 S3 0 1.88 3 S3 0 1.33 3 S3 0 1.77 3 S3 0 2.99 3 S3 0 2.83 3 S3 0 1.8 3 S3 0 1.69 3 S3 0 1.82 3 S3 0 1.04 3 S3 0 0.26 3 S3 0 0.58 3 S3 0 2.31 3 S3 0 2.46 3 S3 0 1.58 3 S3 0 1.57 3 S3 0 2.13 3 S3 0 1.59 3 S3 0 1.95 3 S3 0 1.7 3 S3 0 1.32 3 S3 0 0.81 3 S3 0 2.02 3 S3 0 1.08 3 S3 0 1.59 3 S3 0 3.38 3 S3 0 2.56 3 S3 0 3.3 3 S3 0 1.67 3 S3 0 2.33 3 S3 0 1.44 3 S3 0 0.56 3 S3 0 3.78 3 S3 0 2.55 3 S3 0 3.98 3 S3 0 0.29 3 S3 0 2.37 3 S3 0 2.29 3 S3 0 2.02 3 S3 0 2.68 3 S3 0 2.55 3 S3 0 0.93 3 S3 0 3.26 3 S3 0 0.97 3 S3 0 0.93 3 S3 0 0.76 3 S3 0 3.3 3 S3 0 0.72 3 S3 0 0.98 3 S3 0 1.92 3 S3 0 1.85 3 S3 0 2.39 3 S3 0 1.47 3 S3 0 0.84 3 S3 0 3.6 3 S3 0 2.34 3 S3 0 0.76 3 S3 0 1.5 3 S3 0 2.41 3 S3 0 1.89 3 S3 0 1.98 3 S3 0 1.88 3 S3 0 2.99 3 S3 0 3.81 3 S3 0 2.47 3 S3 0 3.27 3 S3 0 1.19 3 S3 0 3.91 3 S3 0 1.17 3 S3 0 2.02 3 S3 0 1.35 3 S3 0 0.62 3 S3 0 0.4 3 S3 0 1.95 3 S3 0 3.79 3 S3 0 1.37 3 S3 0 2.39 3 S3 0 3.36 3 S3 0 1.62 3 S3 0 2.13 3 S3 0 1.84 3 S3 0 3.16 3 S3 0 1.21 3 S3 0 2.95 3 S3 0 2.88 3 S3 0 2.6 3 S3 0 1.17 3 S3 0 3.45 3 S3 0 0.75 3 S3 0 1.83 3 S3 0 1.27 3 S3 0 1.23 3 S3 0 2.37 3 S3 0 2.84 3 S3 0 2.73 3 S3 0 3.91 3 S3 0 2.78 3 S3 0 1.97 3 S3 0 1.56 3 S3 0 3.97 3 S3 0 2.09 3 S3 0 0.93 3 S3 0 0.28 3 S3 0 2.85 3 S3 0 2.06 3 S3 0 2.24 3 S3 0 2.3 3 S3 0 2.32 3 S3 0 1.59 3 S3 0 0.65 3 S3 0 3.07 3 S3 0 0.87 3 S3 0 1.08 3 S3 0 2.52 3 S3 0 0.56 3 S3 0 1.59 3 S3 0 2.52 3 S3 0 2.37 3 S3 0 0.29 3 S3 0 2.78 3 S3 0 3.91 3 S3 0 2.65 3 S3 0 0.89 3 S3 0 1.57 3 S3 0 1.07 3 S3 0 1.14 3 S3 0 2.91 3 S3 0 3.98 3 S3 0 3.22 3 S3 0 2.01 3 S3 0 1.15 3 S3 0 1.48 3 S3 0 0.71 3 S3 0 1.46 3 S3 0 1.3 3 S3 0 2.63 3 S3 0 3.46 3 S3 0 3.57 3 S3 0 0.77 3 S3 0 0.66 3 S3 0 1.39 3 S3 0 2.48 3 S3 0 3.49 3 S3 0 1.59 3 S3 0 1.01 3 S3 0 1.71 3 S3 0 3.05 3 S3 0 2.1 3 S3 0 1.61 3 S3 0 2.08 3 S3 0 2.93 3 S3 0 1.64 3 S3 0 3.29 3 S3 0 2.34 3 S3 0 3.91 3 S3 0 2.81 3 S3 0 0.71 3 S3 0 2.32 3 S3 0 3.14 3 S3 0 1.52 3 S3 0 3.24 3 S3 0 0.61 3 S3 0 1.7 3 S3 0 2.98 3 S3 0 2.28 3 S3 0 1.56 3 S3 0 1 3 S3 0 0.96 3 S3 0 2.43 3 S3 0 3.17 3 S3 0 0.63 3 S3 0 2.22 3 S3 0 2.28 3 S3 0 1.23 3 S3 0 2.83 3 S3 0 2.55 3 S3 0 2.98 3 S3 0 3.18 3 S3 0 2.62 3 S3 0 0.69 3 S3 0 2.87 3 S3 0 1.13 3 S3 0 1.35 3 S3 0 3.54 3 S3 0 1.37 3 S3 0 1.96 3 S3 0 0.98 3 S3 0 2.56 3 S3 0 2.06 3 S3 0 2.3 3 S3 0 3.39 3 S3 0 1.38 3 S3 0 1.37 3 S3 0 3.39 3 S3 0 0.28 3 S3 0 1.52 3 S3 0 1.13 3 S3 0 3.58 3 S3 0 1.66 3 S3 0 1.6 3 S3 0 1.59 3 S3 0 1.36 3 S3 0 1.65 3 S3 0 3.8 3 S3 0 2.31 3 S3 0 1.25 3 S3 0 1.14 3 S3 0 2.66 3 S3 0 0.73 3 S3 0 0.66 3 S3 0 2.14 3 S3 0 0.63 3 S3 0 3.82 3 S3 0 2.19 3 S3 0 0.76 3 S3 0 3.76 3 S3 0 1.98 3 S3 0 3.5 3 S3 0 2.53 3 S3 0 2.95 3 S3 0 1.53 3 S3 0 1.67 3 S3 0 2.68 3 S3 0 2.03 3 S3 0 2.72 3 S3 0 2.73 3 S3 0 1.87 3 S3 0 3.11 3 S3 0 1.55 3 S3 0 3.56 3 S3 0 1.57 3 S3 0 3.98 3 S3 0 3.97 3 S3 0 3.7 3 S3 0 0.77 3 S3 0 1.32 3 S3 0 2.39 3 S3 0 1.15 3 S3 0 1 3 S3 0 3.8 3 S3 0 3.78 3 S3 0 1.83 3 S3 0 3.08 3 S3 0 1.33 3 S3 0 3.34 3 S3 0 1.65 3 S3 0 2.43 3 S3 0 2.98 3 S3 0 0.71 3 S3 0 1.97 3 S3 0 1.72 3 S3 0 1.11 3 S3 0 1.43 3 S3 0 1.7 3 S3 0 2.15 3 S3 0 2.37 3 S3 0 3.14 3 S3 0 2.57 3 S3 0 3.34 3 S3 0 2.78 3 S3 0 3.28 3 S3 0 3.32 3 S3 0 1.25 3 S3 0 0.82 3 S3 0 1.53 3 S3 0 1.15 3 S3 0 0.79 3 S3 0 2.3 3 S3 0 1.52 3 S3 0 1.11 3 S3 0 2.42 3 S3 0 2.43 3 S3 0 2.03 3 S3 0 3.19 3 S3 0 0.94 3 S3 0 1.68 3 S3 0 1.86 3 S3 0 3.05 3 S3 0 3.14 3 S3 0 2.98 3 S3 0 3.67 3 S3 0 1.16 3 S3 0 2.57 3 S3 0 0.85 3 S3 0 3.34 3 S3 0 3.12 3 S3 0 3.78 3 S3 0 2.47 3 S3 0 2.1 3 S3 0 1.93 3 S3 0 2.74 3 S3 0 2.93 3 S3 0 0.75 3 S3 0 2.72 3 S3 0 1.02 3 S3 0 3.27 3 S3 0 2.81 3 S3 0 2.01 3 S3 0 1.02 3 S3 0 2.47 3 S3 0 3.31 3 S3 0 3.75 3 S3 0 0.91 3 S3 0 2.75 3 S3 0 3.92 3 S3 0 2.53 3 S3 0 2.49 3 S3 0 3.61 3 S3 0 3.11 3 S3 0 1.75 3 S3 0 2 3 S3 0 1.81 3 S3 0 1.01 3 S3 0 1.89 3 S3 0 1.65 3 S3 0 3.42 3 S3 0 2.35 3 S3 0 2.86 3 S3 0 0.31 3 S3 0 2.27 3 S3 0 1.39 3 S3 0 3.75 3 S3 0 0.38 3 S3 0 2.05 3 S3 0 1.83 3 S3 0 2.62 3 S3 0 1.6 3 S3 0 2.23 3 S3 0 3.82 3 S3 0 0.98 3 S3 0 3.61 3 S3 0 3.94 3 S3 0 1.21 3 S3 0 2.36 3 S3 0 1.9 3 S3 0 3.83 3 S3 0 1 3 S3 0 0.99 3 S3 0 2.04 3 S3 0 3.29 3 S3 0 2.36 3 S3 0 3.09 3 S3 0 2.67 3 S3 0 1.42 3 S3 0 2.8 3 S3 0 1.57 3 S3 0 3.85 3 S3 0 2.5 3 S3 0 1.5 3 S3 0 1.46 3 S3 0 3.69 3 S3 0 3.55 3 S3 0 0.98 3 S3 0 3.31 3 S3 0 0.36 3 S3 0 2.12 3 S3 0 3.71 3 S3 0 2.48 3 S3 0 3.08 3 S3 0 2.67 3 S3 0 1.32 3 S3 0 3.79 3 S3 0 2.23 3 S3 0 1.32 3 S3 0 1.82 3 S3 0 3.29 3 S3 0 2.1 3 S3 0 0.77 3 S3 0 2.31 3 S3 0 3.3 3 S3 0 0.76 3 S3 0 2.91 3 S3 0 1.12 3 S3 0 0.65 3 S3 0 2.07 3 S3 0 2.93 3 S3 0 3.82 3 S3 0 2.3 3 S3 0 3.33 3 S3 0 3.43 3 S3 0 2.6 3 S3 0 4 3 S3 0 1.96 3 S3 0 1.35 3 S3 0 0.97 3 S3 0 1.26 3 S3 0 1.97 3 S3 0 3.44 3 S3 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . G16腹围 G17腹围 G18腹围 G19腹围 G20腹围 G21腹围 G22腹围 G23腹围 G24腹围 G25腹围 G26腹围 G27腹围 G28腹围 G29腹围 G30腹围 G31腹围 G32腹围 G33腹围 G34腹围 G35腹围 G36腹围 G37腹围 G38腹围 G39腹围 G40腹围 G41腹围 G42腹围 0 正常 107.6 127.5 133.14 145.37 157.45 197.53 1 抗体阳性 112 126 129.5 143.13 155 204.71 治疗 110 136 153 193.5 216.5 235 253.5 271.5 267 273 297.5 285 308 325 334.3 358 2 3 4 5 6 7 0 0 0 0 正常 抗体阳性 0 0 0 0 0 0 正常 抗体阳性 治疗 * 孕妇甲状腺功能筛查及干预 甲状腺功能筛查可以避免漏诊 异常孕妇中经筛查发现的甲状腺疾病百分比 By thyroid screening By personal or family history Yijie Wu, et al. 5th Huaxia Congress of Endocrinology，2008: Taipei, p49. * 研究结果--妊娠结局 胎儿超声 CH未治疗组 胎儿腹围、股骨↓(P<0.01) CH治疗组 胎儿腹围、股骨与正常组无差异 CH新生儿体重 未治疗组<治疗组<正常组 临床甲减组与正常组胎儿超声腹围比较 Yijie Wu, et al. 5th Huaxia Congress of Endocrinology，2008: Taipei, p49. * 不同甲状腺功能胎儿宫内生长发育指标 双顶径 * # #Δ ▲ ▲☆ 在21周时未治疗组胎儿双顶径明显低于正常对照组（P<0.01） （mm） Chart3 23.33 13w 13w 24.5 24.5 25.25 14w 14w 30.71 30.8 30 30.5 35 33 35.33 34 37 37.25 38 34 57 53.5 21w 50.7 55.89 54.5 55 55.63 57.233 57.333 58.111 57.2 61.1 59.27 60.2 58.5 63.83 62.67 25w 62 67.67 63.5 68.5 62 70.4 66.5 27w 27w 71.78 71.67 72.67 70.5 76.2 75.56 75.5 29w 77.33 77.31 78.29 77.67 81.5 81.14 81 78.7 83.93 83 84.75 81 83.8 78.75 82.43 77.67 84.83 84.21 86.5 83.5 91.33 87.83 88.47 85 90.21 89.33 91 87.8 92.43 91.33 93 91.92 92.56 92.32 92.92 92.14 93.83 92.88 94 91.86 94.33 93.89 94 91.83 95.8 93.33 96.5 92.67 0.25≤TSH≤2.5 2.54治疗 TSH>4未治疗 孕周 双顶径 枕额径 21w 22w 23w 24w 25w 26w 27w 28w 29w 30w 0.25≤TSH≤2.5 70.67 69.52 73.04 75.43 80.67 85.33 91 92.67 97.5 98 2.54治疗 67.6 72.6 75.67 86 92 TSH>4未治疗 66.3 69.71 71.11 73.8 81 90.5 标准 excel标准偏差excel标准偏差函数exl标准差函数国标检验抽样标准表免费下载红头文件格式标准下载 差0 2.983 4.063 4.876 4.49 3.786 6.11 6.028 0.707 11.314 标准差1 3.512 2.726 4.007 3.775 5.033 5.745 4.243 2.872 标准差2 4.561 2.977 4.243 4.243 2.828 标准差3 2.983 4.112 4.336 3.493 2.121 枕额径 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.25≤TSH≤2.5 2.54治疗 TSH>4未治疗 孕周 枕额径 枕额径 头围 21w 22w 23w 24w 25w 26w 27w 28w 29w 30w 31w 0.25≤TSH≤2.5 196.4 202.85 211.22 221.27 239.67 247 271 265.33 276.33 282 285.5 2.54治疗 195.6 208.11 215.5 245.5 268 292 TSH>4未治疗 192.5 202.71 207.4 215.8 212 226 256 280 标准差0 10.669 11.252 14.036 18.635 8.963 14.731 6.364 10.408 1.414 24.194 12.021 标准差1 14.012 8.96 12.341 7.097 13.528 19.687 4.646 标准差2 10.31 9.88 9.192 21.92 15.556 标准差3 17.678 7.387 8.562 6.979 4.243 头围 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.25≤TSH≤2.5 2.54治疗 TSH>4未治疗 孕周 头围 头围 肱骨长 21w 22w 23w 24w 25w 26w 27w 28w 29w 30w 31w 0.25≤TSH≤2.5 36 35.44 38.4 39.73 42.33 46 49 51.67 51 52.67 50 2.54治疗 35.2 37 38 43.5 48 53 TSH>4未治疗 34 36.14 36.91 38.4 40 41 47 62 标准差0 2.132 2.025 2.827 2.781 2.082 2 2.082 1.414 4.933 标准差1 4 2.188 3.163 1.581 2.517 2.872 0.707 2.517 标准差2 3.347 1.936 4.243 4.95 4.243 标准差3 1.414 1.676 0.894 2.881 0 肱骨长 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.25≤TSH≤2.5 2.54治疗 TSH>4未治疗 孕周 肱骨长 肱骨长 胎重 22w 23w 24w 25w 26w 27w 28w 29w 30w 31w 32w 33w 34w 35w 36w 37w 38w 39w 40w 41w 21w 0.25≤TSH≤2.5 550.61 612.35 714.88 844.17 1124 1080.8 1276.56 1597.67 1681.51 1882.9 2112.93 2279.2 2339.71 2709.35 2946.79 3155.5 3275.29 3432.38 3665.56 3635.2 682 2.54治疗 463 608.43 661 998 1288 1550.4 1740 1784.2 2397.33 2269.29 2351.5 3186 2909 3167.29 3309.17 3446 3445.4 3854.5 410 TSH>4未治疗 548.67 631.4 687.2 858 852 1211 1623 1620.67 1803 1958 1896 2045.33 2060 2618.8 2895 3011.43 3056.71 3443.83 3307.33 409 标准差0 128.596 174.206 122.559 80.248 213.07 121.436 169.117 232.163 269.369 313.583 276.219 415.385 208.567 336.103 337.773 337.019 386.455 278.339 76.169 69.236 标准差1 64.553 232.484 97.804 110.309 151.381 146.371 44.744 201.601 161.329 623.842 408.543 212.366 250.969 325.689 255.3 804.602 333.914 167.316 440.836 35.355 标准差2 70.071 76.774 151.321 28.284 145.664 171.14 154.213 90.163 208.904 204.354 346.277 247.374 251.731 377.507 414.9 223.238 218.496 标准差3 85.685 90.79 69.546 144.815 263.793 328.781 236.324 781.727 369.352 147.652 241.079 320.721 226.054 330.448 260.92 397.485 胎重 550.61 516.5 463 548.67 97.804 97.804 612.35 539.24 608.43 631.4 714.88 722.13 661 687.2 844.17 831 25w 858 1124 714.75 998 852 1080.8 886.5 27w 27w 1276.56 1183 1288 1211 1597.67 1433.75 1550.4 1623 1681.51 1533.69 1740 1620.67 1882.9 1870.86 1784.2 1803 2112.93 1800.89 2397.33 1958 2279.2 1965 2269.29 1896 2339.71 2339.33 2351.5 2045.33 2709.35 2586.17 3186 2060 2946.79 2821.76 2909 2618.8 3155.5 3020.71 3167.29 2895 3275.29 3184.15 3309.17 3011.43 3432.38 3333.59 3446 3056.71 3665.56 3447 3445.4 3443.83 3635.2 3551.33 3854.5 3307.33 0.25≤TSH≤2.5 2.54治疗 TSH>4未治疗 孕周 胎重 胎重 双顶径 S 腹左右径 28w 29w 30w 31w 32w 33w 34w 35w 36w 37w 38w 39w 40w 41w 0.25≤TSH≤2.5 76.67 81.57 84.33 88.65 92.75 93.8 94.46 99.24 102.64 104.36 107.84 107.63 111.89 111.33 2.54治疗 75 78 83.29 83.67 89.57 95 96.5 101.67 100.4 102.43 105.42 106.75 108.8 116 TSH>4未治疗 76 80.42 83.25 87.42 88.67 89.4 92.33 98.6 101 105.14 103.57 108.83 108 标准差0 3.67 4.791 4.933 5.334 6.123 3.882 7.601 3.903 5.131 7.009 5.691 5.391 4.886 2.49 标准差1 2.828 7.365 5.838 4.152 5.931 4.033 4.796 6.797 4.125 5.17 4.337 5.754 3.911 1.155 标准差2 3.651 3.094 4.619 4.992 7.024 3.536 5.859 2.881 2.76 5.534 7.394 3.701 1.414 标准差3 0 7.607 3.284 7.211 7.071 5.32 8.145 5.225 6.674 2.268 7.743 3.545 3.464 腹左右径 76.67 72 75 76 81.57 81.25 78 29w 84.33 82.95 83.29 80.42 88.65 87.26 83.67 83.25 92.75 89 89.57 87.42 93.8 89.67 95 88.67 94.46 91.5 96.5 89.4 99.24 96.25 101.67 92.33 102.64 100.55 100.4 98.6 104.36 103.21 102.43 101 107.84 106.18 105.42 105.14 107.63 107.12 106.75 103.57 111.89 109.25 108.8 108.83 111.33 107.8 116 108 0.25≤TSH≤2.5 2.54治疗 TSH>4未治疗 孕周 腹左右径 腹左右径 双顶径一 13w 14w 15w 16w 17w 21w 22w 23w 24w 25w 26w 27w 28w 29w 30w 31w 32w 33w 34w 35w 36w 37w 38w 39w 40w 41w 0.25≤TSH≤2.5 23.33 24.5 30.71 35 37 57 55.89 57.233 61.1 63.83 67.67 70.4 71.78 76.2 77.33 81.5 83.93 83.8 84.83 91.33 90.21 92.43 92.56 93.83 94.33 95.8 2.54治疗 30 35.33 38 55 58.111 60.2 68.5 72.67 75.5 78.29 81 84.75 82.43 86.5 88.47 91 93 92.92 94 94 96.5 TSH>4未治疗 24.5 30.5 34 34 50.7 55.63 57.2 58.5 62 62 70.5 77.67 78.7 81 77.67 83.5 85 87.8 91.92 92.14 91.86 91.83 92.67 标准差0 1.155 2.258 1.89 2.49 1.826 2.751 3.62 4.304 3.795 3.371 4.726 3.782 6.028 2.877 3.927 3.349 3.05 2.7 3.806 2.601 3.731 2.697 4.28 2.069 1.906 2.49 标准差1 1.5 3.271 2.708 0.5 2.646 2.204 3.3431 1.792 2.082 5 3.536 2.872 2.588 3.449 2.734 2.174 3.047 3.43 2.823 2.914 3.039 2.405 2.342 1.85 4.726 标准差2 4.243 0.577 1.414 3.606 3.333 4.95 6.364 2.828 3.512 3.45 2.236 1.708 6.658 0.707 3.055 1.528 2.828 1.379 2.449 1.414 2.121 标准差3 0.707 0.707 1.414 1.414 3.536 2.446 3.9623 3.962 2.121 3.011 3.713 1.732 11.899 4.037 6.557 3.347 2.109 3.132 5.113 3.011 2.082 双顶径一 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.25≤TSH≤2.5 2.54治疗 TSH>4未治疗 孕周 双顶径 胸径一 13w 14w 15w 16w 17w 21w 22w 23w 24w 25w 26w 27w 28w 0.25≤TSH≤2.5 18.5 19 23 26.3 28.17 47 47.28 48.04 52.3 52.5 58 59.2 60.33 2.54治疗 21.5 26 27.5 45.6 48.56 51 59.5 60.67 TSH>4未治疗 16 22 23.5 26 41.4 45.43 47.4 47.5 48 52 58.75 标准差0 1.414 3.651 3.564 2.584 2.483 2.914 4.677 4.196 3.907 3.674 3.606 4.324 2.121 标准差1 2.082 4.472 2.082 1.155 2.646 2.669 3.53 3.02 4 3.464 2.414 5.167 标准差2 2.121 4.95 2.881 3.206 2.121 6.364 2.309 标准差3 2.121 2.828 0.707 3.536 3.259 3.912 2.915 1.5 胸径一 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.25≤TSH≤2.5 2.54治疗 TSH>4未治疗 孕周 胸径 13周至28周胸径 腹径一 13w 14w 15w 16w 17w 21w 22w 23w 24w 25w 26w 27w 28w 0.25≤TSH≤2.5 23 30 31.33 34.33 38.5 57.67 58.04 59.25 62.18 66.17 77 74.8 80.33 2.54治疗 30 35 35.5 57.5 60.8 61 70 78.67 TSH>4未治疗 22 29.5 31 34 54.1 53.87 57.33 59.6 63 69 74.5 标准差0 5.965 2.16 2.398 2.429 4.508 5.063 5.62 4.283 3.061 5.292 8.289 5.431 标准差1 2.517 3.782 2.646 1.732 7.506 6.228 5.348 2.869 1.528 6.652 2.121 2.317 标准差2 5.657 6.364 2.121 3.421 3.606 7.071 4.423 1.155 标准差3 0.707 0.707 6.188 3.564 3.05 4.123 腹径一 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.25≤TSH≤2.5 2.54治疗 TSH>4未治疗 孕周 腹径 13周至28周腹径 腹围一 13w 14w 15w 16w 17w 21w 22w 23w 24w 25w 26w 27w 28w 0.25≤TSH≤2.5 68 77.5 97.67 108.09 116.71 178.67 183.19 193 190.32 209.83 223.67 224.8 243.44 2.54治疗 99 104.67 108.5 176 187.33 193.5 238 238 TSH>4未治疗 70.5 93.5 104.5 109 165.5 170.4 181 185 200 203 230.25 标准差0 6.245 7.503 5.955 9.354 9.656 11.689 23.967 18.246 22.569 6.178 12.662 4.324 15.589 标准差1 6.397 11.194 7.676 4.573 22.502 9.826 15.372 7.931 4.163 15.875 7.778 11.703 标准差2 26.87 5.859 2.121 9.889 11.587 14.849 16.971 17.349 标准差3 0.707 3.536 6.455 10.607 15.188 8.456 11.18 13.937 腹围一 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.25≤TSH≤2.5 2.54治疗 TSH>4未治疗 孕周 腹围 13周至28周腹围 股骨长一 13w 14w 15w 16w 17w 21w 22w 23w 24w 25w 26w 27w 28w 0.25≤TSH≤2.5 10.67 12.17 16.29 19.27 29 38.67 38.85 39.79 43.82 46.33 47 51.8 53.67 2.54治疗 15 20.33 22 37.8 40.4 42 48 52 TSH>4未治疗 9.5 16.5 16.5 20.5 34.9 37.75 39.22 40.8 42 45 50.67 标准差0 0.577 1.329 2.138 2.97 1.272 2.132 2.397 3.12 3.473 2 3.606 0.837 3.5 标准差1 2.062 3.421 1.732 1.472 2.517 2.504 3.104 1.633 2.082 3.304 1.414 3.141 标准差2 2.828 2.517 0.707 3.701 2.108 4.95 7.071 5.033 标准差3 0.707 0.707 1.708 2.828 3.536 2.55 0.894 2.588 2 股骨长一 0 0 0 0 2.138 2.138 3.421 3.421 2.828 2.828 0.707 0.707 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.25≤TSH≤2.5 2.54治疗 TSH>4未治疗 孕周 股骨长 13周至28周股骨长 双顶径二 29w 30w 31w 32w 33w 34w 35w 36w 37w 38w 39w 40w 41w 0.25≤TSH≤2.5 76.2 77.33 81.5 83.93 83.8 84.83 91.33 90.21 92.43 92.56 93.83 94.33 95.8 2.54治疗 75.5 78.29 81 84.75 82.43 86.5 88.47 91 93 92.92 94 94 96.5 TSH>4未治疗 77.67 78.7 81 77.67 83.5 85 87.8 91.92 92.14 91.86 91.83 92.67 标准差0 2.877 3.927 3.349 3.05 2.7 3.806 2.601 3.731 2.697 4.28 2.069 1.906 2.49 标准差1 2.588 3.449 2.734 2.174 3.047 3.43 2.823 2.914 3.039 2.405 2.342 1.85 4.726 标准差2 3.512 3.45 2.236 1.708 6.658 0.707 3.055 1.528 2.828 1.379 2.449 1.414 2.121 标准差3 3.011 3.713 1.732 11.899 4.037 6.557 3.347 2.109 3.132 5.113 3.011 2.082 双顶径二 76.2 75.56 75.5 29w 77.33 77.31 78.29 77.67 81.5 81.14 81 78.7 83.93 83 84.75 81 83.8 78.75 82.43 77.67 84.83 84.21 86.5 83.5 91.33 87.83 88.47 85 90.21 89.33 91 87.8 92.43 91.33 93 91.92 92.56 92.32 92.92 92.14 93.83 92.88 94 91.86 94.33 93.89 94 91.83 95.8 93.33 96.5 92.67 0.25≤TSH≤2.5 2.54治疗 TSH>4未治疗 孕周 双顶径 29周至41周双顶径 胸径二 29w 30w 31w 32w 33w 34w 35w 36w 37w 38w 39w 40w 41w 0.25≤TSH≤2.5 64.33 66.78 72.19 74.64 72.1 75.17 78.71 81 81.15 81.47 81.93 83.17 82 2.54治疗 64.5 67 70.8 73 71 72.5 81.69 79.13 82.29 83.17 81.88 84.4 81.5 TSH>4未治疗 66.83 68.33 70.58 67.25 71.83 75.67 78 80 80.29 80.86 81 79.67 标准差0 2.958 4.577 2.96 3.003 3.665 4.201 3.771 3.771 3.541 4.58 2.586 2.995 4.278 标准差1 3.435 4.059 3.599 3.175 3.367 4.021 4.452 4.452 3.864 3.025 2.781 1.907 3.606 标准差2 3 4.655 3.194 2.363 2.646 3.536 4.726 2.582 2.87 3.129 1 3.209 0.707 标准差3 3.971 3.122 1.732 9.142 2.927 6.028 3.674 5.939 3.147 4.375 3.204 1.528 胸径二 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.25≤TSH≤2.5 2.54治疗 TSH>4未治疗 孕周 胸径 29周至41周胸径 腹径二 29w 30w 31w 32w 33w 34w 35w 36w 37w 38w 39w 40w 41w 0.25≤TSH≤2.5 83.56 82.38 91.14 92.07 94.5 95.64 100.59 103.79 106.05 109.37 110.13 112.89 110.4 2.54治疗 79.25 84.29 88.2 95.75 95.86 96.17 107 101.34 104.14 108.25 109 111.33 119.5 TSH>4未治疗 81 85.33 88.33 84.75 92.17 91.67 99 102.67 106.86 105.57 109.33 110.33 标准差0 4.586 5.284 5.206 4.843 4.625 7.702 4.501 4.682 6.139 5.188 5.438 4.575 2.608 标准差1 6.38 3.32 5.699 3.467 7.988 5.879 4.313 4.423 3.933 6.26 4.619 8.737 标准差2 3.202 2.87 1.924 4.349 5.859 7.778 4.501 5.956 2.854 6.96 7.394 5.675 0.707 标准差3 6.45 6.837 7.506 14.975 8.998 7.638 8.093 4.499 2.795 6.63 3.266 9.074 腹径二 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.25≤TSH≤2.5 2.54治疗 TSH>4未治疗 孕周 腹径 29周至41周腹径 腹围二 29w 30w 31w 32w 33w 34w 35w 36w 37w 38w 39w 40w 41w 0.25≤TSH≤2.5 264.44 265.67 277.23 287.36 296.6 300.79 314.65 327.07 332.68 339.32 342.4 354.33 356.6 2.54治疗 249.5 264.43 269.6 281.25 294.86 301.83 327.33 320.57 334 342.79 343 350.67 373.5 TSH>4未治疗 254.74 272.78 281 268.5 289 297 320.2 320.5 334.57 329.14 341.67 343 标准差0 12.156 38.034 15.449 17.596 13.664 22.168 11.346 14.465 19.074 15.988 17.694 14.025 6.914 标准差1 23.965 12.399 10.111 14.856 19.718 13.992 14.878 13.51 12.728 12.608 16.954 10.899 14.844 标准差2 13.796 7.044 9.555 42.836 11.015 19.799 15.011 14.14 8.287 17.243 18.348 11.777 3.536 标准差3 22.774 18.866 22.539 42.067 16.125 14.731 14.533 18.933 10.454 15.742 8.042 19.925 腹围二 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.25≤TSH≤2.5 2.54治疗 TSH>4未治疗 孕周 腹围 29周至41周腹围 股骨长二 29w 30w 31w 32w 33w 34w 35w 36w 37w 38w 39w 40w 41w 0.25≤TSH≤2.5 55.56 57.23 60.55 61.43 64.4 65.71 67.82 69.93 70.7 72.06 73 74.11 75 2.54治疗 53.25 56.29 59.71 64 61.14 64.67 70.57 71.05 73.43 74 73.75 77.5 TSH>4未治疗 56.67 58.8 60.67 56.25 63 68 69.08 71.83 68.14 72.17 73.67 标准差0 2.789 3.442 2.988 2.138 2.366 4.762 4.762 8.7 2.399 2.616 2.56 2.374 1.581 标准差1 4.506 2.94 2.215 2.29 3.388 2.563 2.146 1.94 1.987 2.182 2.398 2.137 1 标准差2 2.5 1.496 2.168 4.243 2.082 1.414 2.637 2.854 1.946 2.944 1.643 0.707 标准差3 2.066 4.3676 1.155 13.074 2.16 2.739 3.476 0.976 7.647 1.169 1.155 股骨长二 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.25≤TSH≤2.5 2.54治疗 TSH>4未治疗 孕周 股骨长 29周41周股骨长 Chart1 57 53.5 50.7 全 甲功分组 13w 14w 15w 16w 17w 18w 19w 20w 21w 22w 23w 24w 25w 26w 27w 28w 29w 30w 31w 32w 33w 34w 35w 36w 37w 38w 39w 40w 41w 947522 0 35 948157 0 28 948159 0 40 948237 0 37 948360 0 49 948362 0 52 948366 0 24 948741 0 38 948935 0 24 59 948958 0 33 953977 0 45 954088 0 30 954542 0 21 954661 0 32 954809 0 33 955157 0 31 955513 0 22 955631 0 35 955929 0 36 956117 0 39 956777 0 40 956986 0 25 957001 0 28 957064 0 32 957166 0 38 958162 0 34 958183 0 24 958845 0 34 959113 0 31 965282 0 38 966394 0 40 966467 0 36 966892 0 33 967020 0 25 29 967069 0 36 967072 0 24 I0576727 0 36 955792 0 50 955921 0 56 956849 0 55 948157 0 49 948460 0 50 948487 0 49 949063 0 48 958413 0 49 965865 0 52 966833 0 49 953512 0 50 952690 0 56 954088 0 56 954403 0 52 955490 0 53 954542 0 54 954870 0 55 956118 0 56 954693 0 54 957001 0 53 956959 0 59 956986 0 55 955961 0 58 956902 0 62 956582 0 56 956807 0 60 I0576843 0 51 I0576714 0 58 I0576727 0 59 957498 0 55 948159 0 66 957716 0 59 948936 0 53 967072 0 57 965587 0 53 966530 0 58 965667 0 51 953291 0 56 954661 0 53 954948 0 58 955929 0 60 954809 0 64 956337 0 60 956958 0 54 957166 0 60 956816 0 63 I0576796 0 54 I0576618 0 62 948237 0 64 948410 0 47 948133 0 59 958162 0 55 948603 0 58 958413 0 54 958845 0 59 959113 0 53 959136 0 55 958845 0 59 958183 0 57 967020 0 52 966945 0 61 953359 0 56 954938 0 59 955254 0 60 955157 0 65 954659 0 61 955769 0 53 955057 0 59 957064 0 59 956117 0 59 955254 0 60 947522 0 55 948455 0 50 956706 0 58 948366 0 60 948958 0 62 948741 0 66 958691 0 62 966394 0 55 966546 0 58 965282 0 62 967069 0 63 I0577403 0 62 955631 0 66 955564 0 58 I0576712 0 64 956777 0 66 958162 0 67 958183 0 62 956119 0 73 957143 0 64 958573 0 66 953977 0 73 956849 0 73 957013 0 64 I0576796 0 70 I0576859 0 72 953512 0 70 954693 0 68 I0576714 0 73 956709 0 74 957199 0 72 957196 0 72 948286 0 71 966892 0 73 967096 0 73 956164 0 80 957973 0 78 957232 0 77 957522 0 72 948655 0 71 957714 0 77 965865 0 74 I0577403 0 75 966530 0 76 953512 0 71 953291 0 76 954088 0 82 954403 0 78 954542 0 74 954948 0 80 954870 0 78 955254 0 78 956463 0 74 956118 0 79 954693 0 78 955792 0 79 955769 0 75 955921 0 78 955631 0 82 956337 0 77 956812 0 79 956986 0 76 956639 0 63 955254 0 78 956902 0 78 956582 0 73 956816 0 79 I0576843 0 72 I0576712 0 78 I0576727 0 77 948178 0 75 956943 0 77 948159 0 88 948133 0 79 948387 0 71 948360 0 80 948460 0 72 948487 0 79 948603 0 82 948958 0 77 948936 0 79 948935 0 84 958845 0 78 959113 0 74 958845 0 78 967020 0 77 966546 0 78 967072 0 80 967069 0 81 966833 0 76 952690 0 83 953359 0 81 954014 0 75 956040 0 82 956046 0 83 954893 0 76 954809 0 85 955157 0 83 955057 0 82 956959 0 84 957166 0 83 I0576796 0 77 I0576618 0 89 948157 0 80 956777 0 84 958162 0 77 948362 0 81 958413 0 74 958573 0 81 966394 0 84 966467 0 76 965282 0 85 953512 0 78 954661 0 84 955836 0 86 956958 0 79 957001 0 84 957064 0 76 956117 0 83 955961 0 82 956807 0 86 948237 0 88 957716 0 85 948741 0 84 949063 0 85 966945 0 89 954938 0 80 954948 0 87 957862 0 85 955836 0 86 948133 0 85 958691 0 80 959136 0 84 965587 0 87 965730 0 81 965667 0 83 952131 0 82 955490 0 83 955254 0 84 954659 0 88 955721 0 84 956986 0 86 957024 0 88 955254 0 84 957583 0 87 947522 0 77 948455 0 76 955935 0 87 957716 0 85 I0576859 0 88 953291 0 86 952690 0 88 955929 0 90 955921 0 88 956849 0 90 956959 0 92 955721 0 84 957143 0 84 I0576843 0 85 I0576712 0 91 I0576714 0 90 947522 0 82 948366 0 87 959136 0 88 966892 0 88 965587 0 91 I0577403 0 90 966530 0 92 952131 0 85 953551 0 86 954440 0 90 953977 0 88 954870 0 90 956119 0 94 955792 0 91 955646 0 82 955057 0 93 956812 0 92 957064 0 85 954864 0 88 956582 0 89 I0576796 0 91 I0576618 0 96 I0576727 0 92 948157 0 87 955697 0 82 956943 0 90 948133 0 92 948362 0 87 948487 0 90 948645 0 93 948935 0 96 949046 0 90 959113 0 87 959328 0 81 965888 0 93 966394 0 91 967096 0 91 967072 0 91 966807 0 89 966833 0 86 953512 0 91 953359 0 92 954938 0 89 954948 0 86 954893 0 90 955929 0 94 954809 0 96 956118 0 91 954693 0 83 955157 0 91 955769 0 93 955245 0 90 956337 0 91 956958 0 89 956812 0 91 957166 0 94 956117 0 93 956902 0 92 956816 0 92 956807 0 95 948237 0 93 958162 0 91 I0576859 0 93 948362 0 85 948360 0 93 948460 0 89 948741 0 94 958845 0 93 958691 0 89 959121 0 91 958845 0 93 958183 0 90 957902 0 92 958573 0 91 967020 0 90 966546 0 92 965282 0 95 966945 0 96 967069 0 91 965865 0 93 952131 0 90 953291 0 91 954088 0 98 954403 0 90 955490 0 89 954661 0 90 954938 0 90 954809 0 93 956118 0 89 954693 0 88 957001 0 90 956959 0 92 956986 0 93 957166 0 94 956639 0 72 955961 0 93 956582 0 91 956807 0 95 I0576843 0 90 I0576618 0 97 I0576712 0 95 I0576727 0 95 948157 0 91 948133 0 90 956777 0 95 948360 0 95 948603 0 94 958691 0 88 959092 0 94 957714 0 94 966546 0 92 966467 0 93 967096 0 92 967072 0 90 954014 0 95 954542 0 93 954870 0 94 955254 0 90 955929 0 94 954917 0 956119 0 96 955792 0 94 954659 0 94 955921 0 94 955631 0 95 956940 0 95 956335 0 955254 0 90 956902 0 91 956816 0 94 I0576843 0 92 948237 0 95 948178 0 95 948159 0 100 948366 0 94 948958 0 96 948936 0 94 959136 0 97 958183 0 91 957902 0 95 958573 0 93 967020 0 92 966394 0 94 966892 0 93 965667 0 93 952690 0 91 953701 0 92 954014 0 92 953977 0 93 954870 0 94 955631 0 96 956849 0 96 956902 0 92 957143 0 94 957843 0 98 948936 0 94 958845 0 95 958398 0 94 958845 0 95 957714 0 96 958573 0 91 965865 0 93 965667 0 94 953701 0 93 954542 0 92 957001 0 95 948958 0 95 965865 0 89 944130 1 37 948244 1 31 948352 1 26 948496 1 31 953808 1 37 953944 1 37 954248 1 38 955097 1 30 955208 1 37 955853 1 37 955933 1 32 956903 1 27 957247 1 32 957608 1 27 958089 1 49 958303 1 24 958452 1 34 958589 1 24 958691 1 32 966072 1 35 967232 1 26 I576407 1 60 951613 1 55 949080 1 56 953808 1 55 956735 1 56 956812 1 56 956903 1 58 947733 1 51 948352 1 53 966513 1 54 967232 1 53 953550 1 61 953432 1 56 954248 1 57 944130 1 58 955853 1 62 955097 1 54 955921 1 58 956511 1 49 957608 1 57 957564 1 59 957247 1 60 948244 1 59 957799 1 56 959393 1 58 958589 1 61 958628 1 51 958303 1 57 966072 1 59 953296 1 63 955244 1 60 955140 1 59 955933 1 58 957565 1 63 956634 1 61 956511 1 63 956436 1 60 948558 1 62 I0577340 1 62 955208 1 65 959393 1 62 967232 1 61 953531 1 63 958088 1 63 948496 1 53 958452 1 63 948385 1 67 959230 1 62 954013 1 72 955112 1 70 955715 1 72 957361 1 68 956205 1 72 957609 1 76 951613 1 75 955853 1 80 956735 1 77 948385 1 73 958089 1 76 953550 1 81 953944 1 81 953808 1 79 955933 1 72 955921 1 81 956436 1 76 956903 1 81 948244 1 78 947733 1 76 958322 1 75 948352 1 75 958628 1 71 957539 1 79 953432 1 79 954248 1 80 944130 1 81 957565 1 83 958589 1 85 966513 1 77 966072 1 83 953296 1 79 955208 1 85 955859 1 78 955140 1 81 955097 1 81 956047 1 81 957608 1 82 948496 1 80 949045 1 86 959393 1 85 959230 1 79 958303 1 81 954001 1 83 953531 1 83 956634 1 83 956511 1 85 957564 1 85 957799 1 76 965596 1 82 I576407 1 83 953944 1 86 955244 1 88 953227 1 79 955853 1 88 957799 1 85 951613 1 89 953296 1 88 953432 1 91 955057 1 84 956205 1 86 956436 1 86 955614 1 86 948558 1 86 958452 1 87 958089 1 93 966513 1 86 966072 1 92 I576407 1 88 955140 1 91 953227 1 86 955933 1 86 956735 1 92 957112 1 89 956397 1 96 948244 1 89 958322 1 91 949080 1 91 959393 1 90 958723 1 95 966513 1 91 967232 1 88 954011 1 92 953550 1 93 954248 1 88 953808 1 94 953531 1 91 955208 1 96 953227 1 86 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953531 953550 953808 953944 954001 954011 954013 954248 955097 955112 955140 955208 955244 955614 955715 955853 955859 955933 956047 956205 956397 956430 956436 956511 956634 956636 956735 956903 957112 957247 957564 957565 957608 957609 957799 958089 958303 958322 958452 958589 958628 958715 959230 959393 966072 966513 967232 I0577340 I576407 正常上限 正常下限 孕周 双顶径 2.5mU/L4治疗 TSH>4未治疗 孕周 双顶径 枕额径 21w 22w 23w 24w 25w 26w 27w 28w 29w 30w 0.25≤TSH≤2.5 70.67 69.52 73.04 75.43 80.67 85.33 91 92.67 97.5 98 2.54治疗 67.6 72.6 75.67 86 92 TSH>4未治疗 66.3 69.71 71.11 73.8 81 90.5 标准差0 2.983 4.063 4.876 4.49 3.786 6.11 6.028 0.707 11.314 标准差1 3.512 2.726 4.007 3.775 5.033 5.745 4.243 2.872 标准差2 4.561 2.977 4.243 4.243 2.828 标准差3 2.983 4.112 4.336 3.493 2.121 枕额径 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.25≤TSH≤2.5 2.54治疗 TSH>4未治疗 孕周 枕额径 枕额径 头围 21w 22w 23w 24w 25w 26w 27w 28w 29w 30w 31w 0.25≤TSH≤2.5 196.4 202.85 211.22 221.27 239.67 247 271 265.33 276.33 282 285.5 2.54治疗 195.6 208.11 215.5 245.5 268 292 TSH>4未治疗 192.5 202.71 207.4 215.8 212 226 256 280 标准差0 10.669 11.252 14.036 18.635 8.963 14.731 6.364 10.408 1.414 24.194 12.021 标准差1 14.012 8.96 12.341 7.097 13.528 19.687 4.646 标准差2 10.31 9.88 9.192 21.92 15.556 标准差3 17.678 7.387 8.562 6.979 4.243 头围 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.25≤TSH≤2.5 2.54治疗 TSH>4未治疗 孕周 头围 头围 肱骨长 21w 22w 23w 24w 25w 26w 27w 28w 29w 30w 31w 0.25≤TSH≤2.5 36 35.44 38.4 39.73 42.33 46 49 51.67 51 52.67 50 2.54治疗 35.2 37 38 43.5 48 53 TSH>4未治疗 34 36.14 36.91 38.4 40 41 47 62 标准差0 2.132 2.025 2.827 2.781 2.082 2 2.082 1.414 4.933 标准差1 4 2.188 3.163 1.581 2.517 2.872 0.707 2.517 标准差2 3.347 1.936 4.243 4.95 4.243 标准差3 1.414 1.676 0.894 2.881 0 肱骨长 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.25≤TSH≤2.5 2.54治疗 TSH>4未治疗 孕周 肱骨长 肱骨长 胎重 22w 23w 24w 25w 26w 27w 28w 29w 30w 31w 32w 33w 34w 35w 36w 37w 38w 39w 40w 41w 21w 0.25≤TSH≤2.5 550.61 612.35 714.88 844.17 1124 1080.8 1276.56 1597.67 1681.51 1882.9 2112.93 2279.2 2339.71 2709.35 2946.79 3155.5 3275.29 3432.38 3665.56 3635.2 682 2.54治疗 463 608.43 661 998 1288 1550.4 1740 1784.2 2397.33 2269.29 2351.5 3186 2909 3167.29 3309.17 3446 3445.4 3854.5 410 TSH>4未治疗 548.67 631.4 687.2 858 852 1211 1623 1620.67 1803 1958 1896 2045.33 2060 2618.8 2895 3011.43 3056.71 3443.83 3307.33 409 标准差0 128.596 174.206 122.559 80.248 213.07 121.436 169.117 232.163 269.369 313.583 276.219 415.385 208.567 336.103 337.773 337.019 386.455 278.339 76.169 69.236 标准差1 64.553 232.484 97.804 110.309 151.381 146.371 44.744 201.601 161.329 623.842 408.543 212.366 250.969 325.689 255.3 804.602 333.914 167.316 440.836 35.355 标准差2 70.071 76.774 151.321 28.284 145.664 171.14 154.213 90.163 208.904 204.354 346.277 247.374 251.731 377.507 414.9 223.238 218.496 标准差3 85.685 90.79 69.546 144.815 263.793 328.781 236.324 781.727 369.352 147.652 241.079 320.721 226.054 330.448 260.92 397.485 胎重 550.61 516.5 463 548.67 97.804 97.804 612.35 539.24 608.43 631.4 714.88 722.13 661 687.2 844.17 831 25w 858 1124 714.75 998 852 1080.8 886.5 27w 27w 1276.56 1183 1288 1211 1597.67 1433.75 1550.4 1623 1681.51 1533.69 1740 1620.67 1882.9 1870.86 1784.2 1803 2112.93 1800.89 2397.33 1958 2279.2 1965 2269.29 1896 2339.71 2339.33 2351.5 2045.33 2709.35 2586.17 3186 2060 2946.79 2821.76 2909 2618.8 3155.5 3020.71 3167.29 2895 3275.29 3184.15 3309.17 3011.43 3432.38 3333.59 3446 3056.71 3665.56 3447 3445.4 3443.83 3635.2 3551.33 3854.5 3307.33 0.25≤TSH≤2.5 2.54治疗 TSH>4未治疗 孕周 胎重 胎重 双顶径 S 腹左右径 28w 29w 30w 31w 32w 33w 34w 35w 36w 37w 38w 39w 40w 41w 0.25≤TSH≤2.5 76.67 81.57 84.33 88.65 92.75 93.8 94.46 99.24 102.64 104.36 107.84 107.63 111.89 111.33 2.54治疗 75 78 83.29 83.67 89.57 95 96.5 101.67 100.4 102.43 105.42 106.75 108.8 116 TSH>4未治疗 76 80.42 83.25 87.42 88.67 89.4 92.33 98.6 101 105.14 103.57 108.83 108 标准差0 3.67 4.791 4.933 5.334 6.123 3.882 7.601 3.903 5.131 7.009 5.691 5.391 4.886 2.49 标准差1 2.828 7.365 5.838 4.152 5.931 4.033 4.796 6.797 4.125 5.17 4.337 5.754 3.911 1.155 标准差2 3.651 3.094 4.619 4.992 7.024 3.536 5.859 2.881 2.76 5.534 7.394 3.701 1.414 标准差3 0 7.607 3.284 7.211 7.071 5.32 8.145 5.225 6.674 2.268 7.743 3.545 3.464 腹左右径 76.67 72 75 76 81.57 81.25 78 29w 84.33 82.95 83.29 80.42 88.65 87.26 83.67 83.25 92.75 89 89.57 87.42 93.8 89.67 95 88.67 94.46 91.5 96.5 89.4 99.24 96.25 101.67 92.33 102.64 100.55 100.4 98.6 104.36 103.21 102.43 101 107.84 106.18 105.42 105.14 107.63 107.12 106.75 103.57 111.89 109.25 108.8 108.83 111.33 107.8 116 108 0.25≤TSH≤2.5 2.54治疗 TSH>4未治疗 孕周 腹左右径 腹左右径 双顶径一 13w 14w 15w 16w 17w 21w 22w 23w 24w 25w 26w 27w 28w 29w 30w 31w 32w 33w 34w 35w 36w 37w 38w 39w 40w 41w 0.25≤TSH≤2.5 23.33 24.5 30.71 35 37 57 55.89 57.233 61.1 63.83 67.67 70.4 71.78 76.2 77.33 81.5 83.93 83.8 84.83 91.33 90.21 92.43 92.56 93.83 94.33 95.8 2.54治疗 30 35.33 38 55 58.111 60.2 68.5 72.67 75.5 78.29 81 84.75 82.43 86.5 88.47 91 93 92.92 94 94 96.5 TSH>4未治疗 24.5 30.5 34 34 50.7 55.63 57.2 58.5 62 62 70.5 77.67 78.7 81 77.67 83.5 85 87.8 91.92 92.14 91.86 91.83 92.67 标准差0 1.155 2.258 1.89 2.49 1.826 2.751 3.62 4.304 3.795 3.371 4.726 3.782 6.028 2.877 3.927 3.349 3.05 2.7 3.806 2.601 3.731 2.697 4.28 2.069 1.906 2.49 标准差1 1.5 3.271 2.708 0.5 2.646 2.204 3.3431 1.792 2.082 5 3.536 2.872 2.588 3.449 2.734 2.174 3.047 3.43 2.823 2.914 3.039 2.405 2.342 1.85 4.726 标准差2 4.243 0.577 1.414 3.606 3.333 4.95 6.364 2.828 3.512 3.45 2.236 1.708 6.658 0.707 3.055 1.528 2.828 1.379 2.449 1.414 2.121 标准差3 0.707 0.707 1.414 1.414 3.536 2.446 3.9623 3.962 2.121 3.011 3.713 1.732 11.899 4.037 6.557 3.347 2.109 3.132 5.113 3.011 2.082 双顶径一 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.25≤TSH≤2.5 2.54治疗 TSH>4未治疗 孕周 双顶径 胸径一 13w 14w 15w 16w 17w 21w 22w 23w 24w 25w 26w 27w 28w 0.25≤TSH≤2.5 18.5 19 23 26.3 28.17 47 47.28 48.04 52.3 52.5 58 59.2 60.33 2.54治疗 21.5 26 27.5 45.6 48.56 51 59.5 60.67 TSH>4未治疗 16 22 23.5 26 41.4 45.43 47.4 47.5 48 52 58.75 标准差0 1.414 3.651 3.564 2.584 2.483 2.914 4.677 4.196 3.907 3.674 3.606 4.324 2.121 标准差1 2.082 4.472 2.082 1.155 2.646 2.669 3.53 3.02 4 3.464 2.414 5.167 标准差2 2.121 4.95 2.881 3.206 2.121 6.364 2.309 标准差3 2.121 2.828 0.707 3.536 3.259 3.912 2.915 1.5 胸径一 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.25≤TSH≤2.5 2.54治疗 TSH>4未治疗 孕周 胸径 13周至28周胸径 腹径一 13w 14w 15w 16w 17w 21w 22w 23w 24w 25w 26w 27w 28w 0.25≤TSH≤2.5 23 30 31.33 34.33 38.5 57.67 58.04 59.25 62.18 66.17 77 74.8 80.33 2.54治疗 30 35 35.5 57.5 60.8 61 70 78.67 TSH>4未治疗 22 29.5 31 34 54.1 53.87 57.33 59.6 63 69 74.5 标准差0 5.965 2.16 2.398 2.429 4.508 5.063 5.62 4.283 3.061 5.292 8.289 5.431 标准差1 2.517 3.782 2.646 1.732 7.506 6.228 5.348 2.869 1.528 6.652 2.121 2.317 标准差2 5.657 6.364 2.121 3.421 3.606 7.071 4.423 1.155 标准差3 0.707 0.707 6.188 3.564 3.05 4.123 腹径一 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.25≤TSH≤2.5 2.54治疗 TSH>4未治疗 孕周 腹径 13周至28周腹径 腹围一 13w 14w 15w 16w 17w 21w 22w 23w 24w 25w 26w 27w 28w 0.25≤TSH≤2.5 68 77.5 97.67 108.09 116.71 178.67 183.19 193 190.32 209.83 223.67 224.8 243.44 2.54治疗 99 104.67 108.5 176 187.33 193.5 238 238 TSH>4未治疗 70.5 93.5 104.5 109 165.5 170.4 181 185 200 203 230.25 标准差0 6.245 7.503 5.955 9.354 9.656 11.689 23.967 18.246 22.569 6.178 12.662 4.324 15.589 标准差1 6.397 11.194 7.676 4.573 22.502 9.826 15.372 7.931 4.163 15.875 7.778 11.703 标准差2 26.87 5.859 2.121 9.889 11.587 14.849 16.971 17.349 标准差3 0.707 3.536 6.455 10.607 15.188 8.456 11.18 13.937 腹围一 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.25≤TSH≤2.5 2.54治疗 TSH>4未治疗 孕周 腹围 13周至28周腹围 股骨长一 13w 14w 15w 16w 17w 21w 22w 23w 24w 25w 26w 27w 28w 0.25≤TSH≤2.5 10.67 12.17 16.29 19.27 29 38.67 38.85 39.79 43.82 46.33 47 51.8 53.67 2.54治疗 15 20.33 22 37.8 40.4 42 48 52 TSH>4未治疗 9.5 16.5 16.5 20.5 34.9 37.75 39.22 40.8 42 45 50.67 标准差0 0.577 1.329 2.138 2.97 1.272 2.132 2.397 3.12 3.473 2 3.606 0.837 3.5 标准差1 2.062 3.421 1.732 1.472 2.517 2.504 3.104 1.633 2.082 3.304 1.414 3.141 标准差2 2.828 2.517 0.707 3.701 2.108 4.95 7.071 5.033 标准差3 0.707 0.707 1.708 2.828 3.536 2.55 0.894 2.588 2 股骨长一 0 0 0 0 2.138 2.138 3.421 3.421 2.828 2.828 0.707 0.707 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.25≤TSH≤2.5 2.54治疗 TSH>4未治疗 孕周 股骨长 13周至28周股骨长 双顶径二 29w 30w 31w 32w 33w 34w 35w 36w 37w 38w 39w 40w 41w 0.25≤TSH≤2.5 76.2 77.33 81.5 83.93 83.8 84.83 91.33 90.21 92.43 92.56 93.83 94.33 95.8 2.54治疗 75.5 78.29 81 84.75 82.43 86.5 88.47 91 93 92.92 94 94 96.5 TSH>4未治疗 77.67 78.7 81 77.67 83.5 85 87.8 91.92 92.14 91.86 91.83 92.67 标准差0 2.877 3.927 3.349 3.05 2.7 3.806 2.601 3.731 2.697 4.28 2.069 1.906 2.49 标准差1 2.588 3.449 2.734 2.174 3.047 3.43 2.823 2.914 3.039 2.405 2.342 1.85 4.726 标准差2 3.512 3.45 2.236 1.708 6.658 0.707 3.055 1.528 2.828 1.379 2.449 1.414 2.121 标准差3 3.011 3.713 1.732 11.899 4.037 6.557 3.347 2.109 3.132 5.113 3.011 2.082 双顶径二 76.2 75.56 75.5 29w 77.33 77.31 78.29 77.67 81.5 81.14 81 78.7 83.93 83 84.75 81 83.8 78.75 82.43 77.67 84.83 84.21 86.5 83.5 91.33 87.83 88.47 85 90.21 89.33 91 87.8 92.43 91.33 93 91.92 92.56 92.32 92.92 92.14 93.83 92.88 94 91.86 94.33 93.89 94 91.83 95.8 93.33 96.5 92.67 0.25≤TSH≤2.5 2.54治疗 TSH>4未治疗 孕周 双顶径 29周至41周双顶径 胸径二 29w 30w 31w 32w 33w 34w 35w 36w 37w 38w 39w 40w 41w 0.25≤TSH≤2.5 64.33 66.78 72.19 74.64 72.1 75.17 78.71 81 81.15 81.47 81.93 83.17 82 2.54治疗 64.5 67 70.8 73 71 72.5 81.69 79.13 82.29 83.17 81.88 84.4 81.5 TSH>4未治疗 66.83 68.33 70.58 67.25 71.83 75.67 78 80 80.29 80.86 81 79.67 标准差0 2.958 4.577 2.96 3.003 3.665 4.201 3.771 3.771 3.541 4.58 2.586 2.995 4.278 标准差1 3.435 4.059 3.599 3.175 3.367 4.021 4.452 4.452 3.864 3.025 2.781 1.907 3.606 标准差2 3 4.655 3.194 2.363 2.646 3.536 4.726 2.582 2.87 3.129 1 3.209 0.707 标准差3 3.971 3.122 1.732 9.142 2.927 6.028 3.674 5.939 3.147 4.375 3.204 1.528 胸径二 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.25≤TSH≤2.5 2.54治疗 TSH>4未治疗 孕周 胸径 29周至41周胸径 腹径二 29w 30w 31w 32w 33w 34w 35w 36w 37w 38w 39w 40w 41w 0.25≤TSH≤2.5 83.56 82.38 91.14 92.07 94.5 95.64 100.59 103.79 106.05 109.37 110.13 112.89 110.4 2.54治疗 79.25 84.29 88.2 95.75 95.86 96.17 107 101.34 104.14 108.25 109 111.33 119.5 TSH>4未治疗 81 85.33 88.33 84.75 92.17 91.67 99 102.67 106.86 105.57 109.33 110.33 标准差0 4.586 5.284 5.206 4.843 4.625 7.702 4.501 4.682 6.139 5.188 5.438 4.575 2.608 标准差1 6.38 3.32 5.699 3.467 7.988 5.879 4.313 4.423 3.933 6.26 4.619 8.737 标准差2 3.202 2.87 1.924 4.349 5.859 7.778 4.501 5.956 2.854 6.96 7.394 5.675 0.707 标准差3 6.45 6.837 7.506 14.975 8.998 7.638 8.093 4.499 2.795 6.63 3.266 9.074 腹径二 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.25≤TSH≤2.5 2.54治疗 TSH>4未治疗 孕周 腹径 29周至41周腹径 腹围二 29w 30w 31w 32w 33w 34w 35w 36w 37w 38w 39w 40w 41w 0.25≤TSH≤2.5 264.44 265.67 277.23 287.36 296.6 300.79 314.65 327.07 332.68 339.32 342.4 354.33 356.6 2.54治疗 249.5 264.43 269.6 281.25 294.86 301.83 327.33 320.57 334 342.79 343 350.67 373.5 TSH>4未治疗 254.74 272.78 281 268.5 289 297 320.2 320.5 334.57 329.14 341.67 343 标准差0 12.156 38.034 15.449 17.596 13.664 22.168 11.346 14.465 19.074 15.988 17.694 14.025 6.914 标准差1 23.965 12.399 10.111 14.856 19.718 13.992 14.878 13.51 12.728 12.608 16.954 10.899 14.844 标准差2 13.796 7.044 9.555 42.836 11.015 19.799 15.011 14.14 8.287 17.243 18.348 11.777 3.536 标准差3 22.774 18.866 22.539 42.067 16.125 14.731 14.533 18.933 10.454 15.742 8.042 19.925 腹围二 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.25≤TSH≤2.5 2.54治疗 TSH>4未治疗 孕周 腹围 29周至41周腹围 股骨长二 29w 30w 31w 32w 33w 34w 35w 36w 37w 38w 39w 40w 41w 0.25≤TSH≤2.5 55.56 57.23 60.55 61.43 64.4 65.71 67.82 69.93 70.7 72.06 73 74.11 75 2.54治疗 53.25 56.29 59.71 64 61.14 64.67 70.57 71.05 73.43 74 73.75 77.5 TSH>4未治疗 56.67 58.8 60.67 56.25 63 68 69.08 71.83 68.14 72.17 73.67 标准差0 2.789 3.442 2.988 2.138 2.366 4.762 4.762 8.7 2.399 2.616 2.56 2.374 1.581 标准差1 4.506 2.94 2.215 2.29 3.388 2.563 2.146 1.94 1.987 2.182 2.398 2.137 1 标准差2 2.5 1.496 2.168 4.243 2.082 1.414 2.637 2.854 1.946 2.944 1.643 0.707 标准差3 2.066 4.3676 1.155 13.074 2.16 2.739 3.476 0.976 7.647 1.169 1.155 股骨长二 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.25≤TSH≤2.5 2.54治疗 TSH>4未治疗 孕周 股骨长 29周41周股骨长 Chart2 81.5 81.14 81 78.7 全 甲功分组 13w 14w 15w 16w 17w 18w 19w 20w 21w 22w 23w 24w 25w 26w 27w 28w 29w 30w 31w 32w 33w 34w 35w 36w 37w 38w 39w 40w 41w 947522 0 35 948157 0 28 948159 0 40 948237 0 37 948360 0 49 948362 0 52 948366 0 24 948741 0 38 948935 0 24 59 948958 0 33 953977 0 45 954088 0 30 954542 0 21 954661 0 32 954809 0 33 955157 0 31 955513 0 22 955631 0 35 955929 0 36 956117 0 39 956777 0 40 956986 0 25 957001 0 28 957064 0 32 957166 0 38 958162 0 34 958183 0 24 958845 0 34 959113 0 31 965282 0 38 966394 0 40 966467 0 36 966892 0 33 967020 0 25 29 967069 0 36 967072 0 24 I0576727 0 36 955792 0 50 955921 0 56 956849 0 55 948157 0 49 948460 0 50 948487 0 49 949063 0 48 958413 0 49 965865 0 52 966833 0 49 953512 0 50 952690 0 56 954088 0 56 954403 0 52 955490 0 53 954542 0 54 954870 0 55 956118 0 56 954693 0 54 957001 0 53 956959 0 59 956986 0 55 955961 0 58 956902 0 62 956582 0 56 956807 0 60 I0576843 0 51 I0576714 0 58 I0576727 0 59 957498 0 55 948159 0 66 957716 0 59 948936 0 53 967072 0 57 965587 0 53 966530 0 58 965667 0 51 953291 0 56 954661 0 53 954948 0 58 955929 0 60 954809 0 64 956337 0 60 956958 0 54 957166 0 60 956816 0 63 I0576796 0 54 I0576618 0 62 948237 0 64 948410 0 47 948133 0 59 958162 0 55 948603 0 58 958413 0 54 958845 0 59 959113 0 53 959136 0 55 958845 0 59 958183 0 57 967020 0 52 966945 0 61 953359 0 56 954938 0 59 955254 0 60 955157 0 65 954659 0 61 955769 0 53 955057 0 59 957064 0 59 956117 0 59 955254 0 60 947522 0 55 948455 0 50 956706 0 58 948366 0 60 948958 0 62 948741 0 66 958691 0 62 966394 0 55 966546 0 58 965282 0 62 967069 0 63 I0577403 0 62 955631 0 66 955564 0 58 I0576712 0 64 956777 0 66 958162 0 67 958183 0 62 956119 0 73 957143 0 64 958573 0 66 953977 0 73 956849 0 73 957013 0 64 I0576796 0 70 I0576859 0 72 953512 0 70 954693 0 68 I0576714 0 73 956709 0 74 957199 0 72 957196 0 72 948286 0 71 966892 0 73 967096 0 73 956164 0 80 957973 0 78 957232 0 77 957522 0 72 948655 0 71 957714 0 77 965865 0 74 I0577403 0 75 966530 0 76 953512 0 71 953291 0 76 954088 0 82 954403 0 78 954542 0 74 954948 0 80 954870 0 78 955254 0 78 956463 0 74 956118 0 79 954693 0 78 955792 0 79 955769 0 75 955921 0 78 955631 0 82 956337 0 77 956812 0 79 956986 0 76 956639 0 63 955254 0 78 956902 0 78 956582 0 73 956816 0 79 I0576843 0 72 I0576712 0 78 I0576727 0 77 948178 0 75 956943 0 77 948159 0 88 948133 0 79 948387 0 71 948360 0 80 948460 0 72 948487 0 79 948603 0 82 948958 0 77 948936 0 79 948935 0 84 958845 0 78 959113 0 74 958845 0 78 967020 0 77 966546 0 78 967072 0 80 967069 0 81 966833 0 76 952690 0 83 953359 0 81 954014 0 75 956040 0 82 956046 0 83 954893 0 76 954809 0 85 955157 0 83 955057 0 82 956959 0 84 957166 0 83 I0576796 0 77 I0576618 0 89 948157 0 80 956777 0 84 958162 0 77 948362 0 81 958413 0 74 958573 0 81 966394 0 84 966467 0 76 965282 0 85 953512 0 78 954661 0 84 955836 0 86 956958 0 79 957001 0 84 957064 0 76 956117 0 83 955961 0 82 956807 0 86 948237 0 88 957716 0 85 948741 0 84 949063 0 85 966945 0 89 954938 0 80 954948 0 87 957862 0 85 955836 0 86 948133 0 85 958691 0 80 959136 0 84 965587 0 87 965730 0 81 965667 0 83 952131 0 82 955490 0 83 955254 0 84 954659 0 88 955721 0 84 956986 0 86 957024 0 88 955254 0 84 957583 0 87 947522 0 77 948455 0 76 955935 0 87 957716 0 85 I0576859 0 88 953291 0 86 952690 0 88 955929 0 90 955921 0 88 956849 0 90 956959 0 92 955721 0 84 957143 0 84 I0576843 0 85 I0576712 0 91 I0576714 0 90 947522 0 82 948366 0 87 959136 0 88 966892 0 88 965587 0 91 I0577403 0 90 966530 0 92 952131 0 85 953551 0 86 954440 0 90 953977 0 88 954870 0 90 956119 0 94 955792 0 91 955646 0 82 955057 0 93 956812 0 92 957064 0 85 954864 0 88 956582 0 89 I0576796 0 91 I0576618 0 96 I0576727 0 92 948157 0 87 955697 0 82 956943 0 90 948133 0 92 948362 0 87 948487 0 90 948645 0 93 948935 0 96 949046 0 90 959113 0 87 959328 0 81 965888 0 93 966394 0 91 967096 0 91 967072 0 91 966807 0 89 966833 0 86 953512 0 91 953359 0 92 954938 0 89 954948 0 86 954893 0 90 955929 0 94 954809 0 96 956118 0 91 954693 0 83 955157 0 91 955769 0 93 955245 0 90 956337 0 91 956958 0 89 956812 0 91 957166 0 94 956117 0 93 956902 0 92 956816 0 92 956807 0 95 948237 0 93 958162 0 91 I0576859 0 93 948362 0 85 948360 0 93 948460 0 89 948741 0 94 958845 0 93 958691 0 89 959121 0 91 958845 0 93 958183 0 90 957902 0 92 958573 0 91 967020 0 90 966546 0 92 965282 0 95 966945 0 96 967069 0 91 965865 0 93 952131 0 90 953291 0 91 954088 0 98 954403 0 90 955490 0 89 954661 0 90 954938 0 90 954809 0 93 956118 0 89 954693 0 88 957001 0 90 956959 0 92 956986 0 93 957166 0 94 956639 0 72 955961 0 93 956582 0 91 956807 0 95 I0576843 0 90 I0576618 0 97 I0576712 0 95 I0576727 0 95 948157 0 91 948133 0 90 956777 0 95 948360 0 95 948603 0 94 958691 0 88 959092 0 94 957714 0 94 966546 0 92 966467 0 93 967096 0 92 967072 0 90 954014 0 95 954542 0 93 954870 0 94 955254 0 90 955929 0 94 954917 0 956119 0 96 955792 0 94 954659 0 94 955921 0 94 955631 0 95 956940 0 95 956335 0 955254 0 90 956902 0 91 956816 0 94 I0576843 0 92 948237 0 95 948178 0 95 948159 0 100 948366 0 94 948958 0 96 948936 0 94 959136 0 97 958183 0 91 957902 0 95 958573 0 93 967020 0 92 966394 0 94 966892 0 93 965667 0 93 952690 0 91 953701 0 92 954014 0 92 953977 0 93 954870 0 94 955631 0 96 956849 0 96 956902 0 92 957143 0 94 957843 0 98 948936 0 94 958845 0 95 958398 0 94 958845 0 95 957714 0 96 958573 0 91 965865 0 93 965667 0 94 953701 0 93 954542 0 92 957001 0 95 948958 0 95 965865 0 89 944130 1 37 948244 1 31 948352 1 26 948496 1 31 953808 1 37 953944 1 37 954248 1 38 955097 1 30 955208 1 37 955853 1 37 955933 1 32 956903 1 27 957247 1 32 957608 1 27 958089 1 49 958303 1 24 958452 1 34 958589 1 24 958691 1 32 966072 1 35 967232 1 26 I576407 1 60 951613 1 55 949080 1 56 953808 1 55 956735 1 56 956812 1 56 956903 1 58 947733 1 51 948352 1 53 966513 1 54 967232 1 53 953550 1 61 953432 1 56 954248 1 57 944130 1 58 955853 1 62 955097 1 54 955921 1 58 956511 1 49 957608 1 57 957564 1 59 957247 1 60 948244 1 59 957799 1 56 959393 1 58 958589 1 61 958628 1 51 958303 1 57 966072 1 59 953296 1 63 955244 1 60 955140 1 59 955933 1 58 957565 1 63 956634 1 61 956511 1 63 956436 1 60 948558 1 62 I0577340 1 62 955208 1 65 959393 1 62 967232 1 61 953531 1 63 958088 1 63 948496 1 53 958452 1 63 948385 1 67 959230 1 62 954013 1 72 955112 1 70 955715 1 72 957361 1 68 956205 1 72 957609 1 76 951613 1 75 955853 1 80 956735 1 77 948385 1 73 958089 1 76 953550 1 81 953944 1 81 953808 1 79 955933 1 72 955921 1 81 956436 1 76 956903 1 81 948244 1 78 947733 1 76 958322 1 75 948352 1 75 958628 1 71 957539 1 79 953432 1 79 954248 1 80 944130 1 81 957565 1 83 958589 1 85 966513 1 77 966072 1 83 953296 1 79 955208 1 85 955859 1 78 955140 1 81 955097 1 81 956047 1 81 957608 1 82 948496 1 80 949045 1 86 959393 1 85 959230 1 79 958303 1 81 954001 1 83 953531 1 83 956634 1 83 956511 1 85 957564 1 85 957799 1 76 965596 1 82 I576407 1 83 953944 1 86 955244 1 88 953227 1 79 955853 1 88 957799 1 85 951613 1 89 953296 1 88 953432 1 91 955057 1 84 956205 1 86 956436 1 86 955614 1 86 948558 1 86 958452 1 87 958089 1 93 966513 1 86 966072 1 92 I576407 1 88 955140 1 91 953227 1 86 955933 1 86 956735 1 92 957112 1 89 956397 1 96 948244 1 89 958322 1 91 949080 1 91 959393 1 90 958723 1 95 966513 1 91 967232 1 88 954011 1 92 953550 1 93 954248 1 88 953808 1 94 953531 1 91 955208 1 96 953227 1 86 955097 1 92 957565 1 95 956634 1 88 956511 1 92 956636 1 92 956903 1 91 957247 1 95 948385 1 89 948352 1 88 948496 1 91 949080 1 95 958589 1 95 958628 1 88 958303 1 87 I576407 1 91 951613 1 944130 1 92 954013 1 90 955853 1 98 955933 1 91 955921 1 92 955057 1 91 956735 1 94 956397 1 98 956436 1 93 957608 1 90 957564 1 94 948244 1 92 947733 1 90 957799 1 95 958715 1 91 967232 1 92 965596 1 91 966072 1 95 954011 1 94 953944 1 95 953808 1 93 954013 1 91 955853 1 96 955097 1 94 956430 1 88 956634 1 92 956205 1 90 956636 1 93 956436 1 93 I0576714 1 94 958322 1 97 948385 1 95 948352 1 91 958452 1 93 959230 1 90 953432 1 91 954248 1 90 944130 1 93 956735 1 94 957064 1 91 957565 1 96 956205 1 91 957608 1 92 948763 1 90 959121 1 93 958628 1 90 958303 1 91 953944 1 97 956636 1 95 948558 1 88 955794 2 33 956676 2 37 956945 2 35 956953 2 27 957945 2 36 958834 2 39 965911 2 35 956905 2 56 948979 2 55 955165 2 60 965796 2 50 965596 2 54 955794 2 56 954949 2 53 954965 2 58 956945 2 60 956676 2 61 956953 2 55 957945 2 64 967726 2 57 965911 2 59 I0576715 2 55 958834 2 62 955875 2 73 955115 2 64 956091 2 74 956022 2 72 954556 2 72 955514 2 73 957945 2 79 948979 2 78 956091 2 81 955794 2 76 956676 2 81 I0576715 2 77 955165 2 81 965796 2 72 965596 2 80 949806 2 84 954965 2 78 956905 2 81 949005 2 80 965911 2 82 956945 2 85 955643 2 87 947195 2 84 958834 2 83 954949 2 82 965796 2 70 967726 2 81 954965 2 87 I0576715 2 86 967726 2 956091 2 88 956022 2 92 956509 2 94 952530 2 93 949806 2 92 955794 2 89 956953 2 89 957945 2 91 948979 2 92 955165 2 91 949806 2 96 955875 2 94 955532 2 91 956953 2 88 965596 2 96 967726 2 93 965911 2 93 956022 2 95 954949 2 93 954965 2 92 956945 2 96 956905 2 91 957945 2 93 948979 2 93 949108 2 94 949005 2 92 958834 2 96 965796 2 89 967726 2 93 956945 2 96 956676 2 93 965596 2 96 965911 2 91 954949 2 92 954965 2 95 957945 2 93 949005 2 95 955165 2 95 952530 2 98 955165 2 95 951819 3 44 954606 3 30 954831 3 33 955093 3 33 956116 3 35 956653 3 25 957984 3 34 966329 3 31 966517 3 24 967322 3 33 I0576797 3 36 957984 3 56 948839 3 51 948276 3 60 I0576540 3 56 954831 3 53 955927 3 58 956653 3 53 948613 3 56 966329 3 54 967084 3 55 952241 3 58 955093 3 58 956907 3 57 956116 3 51 956336 3 62 957250 3 58 I0576797 3 65 949064 3 57 967301 3 57 967322 3 64 957031 3 62 948747 3 68 954606 3 71 I0576540 3 75 957226 3 73 957165 3 71 956907 3 72 956116 3 74 957250 3 77 I0576797 3 82 957984 3 80 966329 3 75 967084 3 78 948276 3 75 955093 3 80 954831 3 77 956653 3 75 957250 3 78 956736 3 78 948337 3 88 948604 3 80 949064 3 79 967301 3 77 955927 3 81 948839 3 84 967322 3 84 956336 3 85 955897 3 86 948699 3 83 966517 3 61 954606 3 84 956907 3 80 957234 3 83 956116 3 80 I0576797 3 91 948239 3 83 954554 3 79 948276 3 84 966517 3 92 956907 3 82 957984 3 89 948604 3 90 966329 3 90 967301 3 88 952241 3 90 955093 3 94 I0576540 3 94 956653 3 88 957250 3 92 948239 3 90 948730 3 90 948839 3 94 949064 3 94 949054 3 94 967084 3 91 967322 3 92 955093 3 93 955927 3 89 956653 3 89 I0576797 3 96 949054 3 94 966329 3 91 967322 3 95 956116 3 86 956336 3 93 948239 3 90 948839 3 95 958527 3 85 966517 3 95 967322 3 99 952241 3 93 954606 3 91 I0576540 3 97 957250 3 97 957984 3 97 967301 3 91 948276 3 91 954606 3 90 957250 3 94 956096 4 35 965446 4 35 959072 4 50 967056 4 55 955328 4 67 957442 4 52 965446 4 59 956096 4 70 959072 4 73 957442 4 78 967056 4 80 955328 4 83 954915 4 78 965446 4 80 957442 4 92 955328 4 94 959072 4 91 967056 4 88 955787 4 92 956096 4 90 959072 4 93 967056 4 93 965446 4 91 955328 4 94 955874 5 39 956277 5 38 958114 5 31 958685 5 27 958868 5 34 958192 5 56 958588 5 59 958114 5 56 966937 5 54 958868 5 51 958685 5 59 955874 5 67 956277 5 66 948260 5 72 958868 5 74 958588 5 78 966937 5 74 958685 5 78 958114 5 81 956277 5 84 957469 5 80 948260 5 86 958192 5 86 966937 5 93 958032 5 87 958868 5 86 958588 5 95 958114 5 92 958588 5 97 958685 5 94 956277 5 95 958192 5 92 948260 5 96 958868 5 93 948260 5 94 958192 5 95 965665 6 26 966220 6 25 957546 6 58 965665 6 54 966220 6 53 958019 6 66 966220 6 74 957546 6 81 965665 6 81 958019 6 85 965665 6 86 957546 6 90 965665 6 92 966220 6 89 957546 6 95 958019 6 94 前四组 甲功分组 13w 14w 15w 16w 17w 18w 19w 20w 21w 22w 23w 24w 25w 26w 27w 28w 29w 30w 31w 32w 33w 34w 35w 36w 37w 38w 39w 40w 41w 947522 0 35 55 77 82 948157 0 28 49 80 87 91 948159 0 40 66 88 100 948178 0 75 95 948237 0 37 64 88 93 95 948360 0 49 80 948362 0 52 81 87 85 948366 0 24 60 87 94 948455 0 50 76 948460 0 50 72 89 948487 0 49 79 90 948603 0 58 82 94 948741 0 38 66 84 94 948935 0 24 59 84 96 948936 0 53 79 94 94 948958 0 33 62 77 96 95 949046 0 90 949063 0 48 85 952131 0 82 85 90 952690 0 56 83 88 91 953291 0 56 76 86 91 953359 0 56 81 92 953512 0 50 70 71 78 91 953551 0 86 953701 0 92 93 953977 0 45 73 88 93 954014 0 75 95 92 954088 0 30 56 82 98 954403 0 52 78 90 954440 0 90 954542 0 21 54 74 93 92 954659 0 61 88 94 954661 0 32 53 84 90 954693 0 54 68 78 83 88 954693 0 68 954809 0 33 64 85 96 93 954864 0 88 954870 0 55 78 90 94 94 954893 0 76 90 954917 0 954938 0 59 80 89 90 954948 0 58 80 87 86 955057 0 59 82 84 93 91 955157 0 31 65 83 91 955245 0 90 955254 0 60 78 84 90 955490 0 53 83 89 955513 0 22 955564 0 58 955631 0 35 66 82 95 96 955646 0 82 955697 0 82 955721 0 84 84 955769 0 53 75 93 955792 0 50 79 91 94 955836 0 86 86 955921 0 56 58 81 88 92 94 955929 0 36 60 90 94 94 955935 0 87 955961 0 58 82 93 956040 0 82 956046 0 83 956117 0 39 59 83 93 956118 0 56 79 91 89 956119 0 73 94 96 956164 0 80 956335 0 956337 0 60 77 91 956463 0 74 956582 0 56 73 89 91 956639 0 63 72 956706 0 58 956709 0 74 956777 0 40 66 84 95 956807 0 60 86 95 95 956812 0 56 79 92 91 956816 0 63 79 92 94 956849 0 55 73 90 96 956902 0 62 78 92 91 92 956940 0 95 956943 0 77 90 956958 0 54 79 89 956959 0 59 84 92 92 956986 0 25 55 76 86 93 957001 0 28 53 84 90 95 957013 0 64 957024 0 88 957064 0 32 59 76 85 91 957143 0 64 84 94 957166 0 38 60 83 94 94 957196 0 72 957199 0 72 957232 0 77 957714 0 77 94 96 957716 0 59 85 85 957862 0 85 957902 0 92 95 957973 0 78 958162 0 34 55 67 77 91 958183 0 24 57 62 90 91 958413 0 49 54 74 958573 0 66 81 91 93 91 958691 0 32 62 80 89 88 958845 0 34 59 78 93 95 959092 0 94 959113 0 31 53 74 87 959121 0 91 93 959136 0 55 84 88 97 959328 0 81 965282 0 38 62 85 95 965587 0 53 87 91 965667 0 51 83 93 94 965865 0 52 74 93 93 89 965888 0 93 966394 0 40 55 84 91 94 966467 0 36 76 93 966530 0 58 76 92 966546 0 58 78 92 92 966807 0 89 966833 0 49 76 86 966892 0 33 73 88 93 966945 0 61 89 96 967020 0 25 29 52 77 90 92 967069 0 36 63 81 91 967072 0 24 57 80 91 90 967096 0 73 91 92 I0576618 0 62 89 96 97 I0576712 0 64 78 91 95 I0576714 0 58 73 90 94 I0576727 0 36 59 77 92 95 I0576796 0 54 70 77 91 I0576843 0 51 72 85 90 92 I0576859 0 72 88 93 I0577403 0 62 75 90 944130 1 37 58 81 92 93 947733 1 51 59 79 85 92 90 948244 1 31 59 78 89 92 948352 1 26 53 75 88 91 948385 1 67 73 89 95 948496 1 31 53 80 91 948558 1 62 86 88 949045 1 86 949080 1 56 91 95 951613 1 55 75 89 953227 1 79 86 86 953296 1 63 79 88 953432 1 56 79 91 91 953531 1 63 83 91 953550 1 61 81 93 953808 1 37 55 79 94 93 953944 1 37 81 86 95 96 954001 1 83 954011 1 92 94 954013 1 72 90 91 954248 1 38 57 80 88 90 955097 1 30 54 81 92 94 955112 1 70 955140 1 59 81 91 955208 1 37 65 85 96 955244 1 60 88 955614 1 86 955715 1 72 955853 1 37 62 80 88 98 96 955859 1 78 955933 1 32 58 72 86 91 956047 1 81 956205 1 72 86 90 91 956397 1 96 98 956430 1 88 956436 1 60 76 86 93 93 956511 1 49 63 85 92 956634 1 61 83 88 92 956636 1 92 93 95 956735 1 56 77 92 94 94 956903 1 27 58 81 91 957112 1 89 957247 1 32 60 95 957564 1 59 85 94 957565 1 63 83 95 96 957608 1 27 57 82 90 92 957609 1 76 957799 1 56 76 85 95 958089 1 49 76 93 958303 1 24 57 81 87 91 958322 1 75 91 97 958452 1 34 63 87 93 958589 1 24 61 85 95 958628 1 51 71 88 90 958715 1 91 959230 1 62 79 90 959393 1 58 62 85 90 966072 1 35 59 83 92 95 966513 1 54 77 86 91 967232 1 26 53 61 88 92 I0577340 1 62 I576407 1 60 83 88 91 948979 2 55 78 92 93 949005 2 80 92 95 949108 2 94 949806 2 84 92 96 952530 2 93 98 954556 2 72 954949 2 53 82 93 92 954965 2 58 78 87 92 95 955115 2 64 955165 2 60 81 91 95 95 955514 2 73 955532 2 91 955643 2 87 955794 2 33 56 76 89 955875 2 73 94 956022 2 72 92 95 956091 2 74 81 88 956509 2 94 956676 2 37 61 81 93 956905 2 56 81 91 956945 2 35 60 85 96 96 956953 2 27 55 89 88 957945 2 36 64 79 91 93 93 958834 2 39 62 83 96 965596 2 54 80 82 91 96 965796 2 50 72 70 89 965911 2 35 59 82 93 91 967726 2 57 81 93 93 I0576715 2 55 77 86 948239 3 83 90 90 948276 3 60 75 84 91 948604 3 80 90 948839 3 51 84 94 95 949054 3 94 94 949064 3 57 79 94 951819 3 44 952241 3 58 90 93 954554 3 79 954606 3 30 71 84 91 90 954831 3 33 53 77 955093 3 33 58 80 94 93 955897 3 86 955927 3 58 81 89 956116 3 35 51 74 80 86 956336 3 62 85 93 956653 3 25 53 75 88 89 956736 3 78 956907 3 57 72 80 82 957031 3 62 957165 3 71 957226 3 73 957234 3 83 957250 3 58 77 78 92 97 94 957984 3 34 56 80 89 97 958527 3 85 966329 3 31 54 75 90 91 966517 3 24 61 92 95 967084 3 55 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0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 944130 947733 948244 948352 948385 948496 948558 949045 949080 951613 953227 953296 953432 953531 953550 953808 953944 954001 954011 954013 954248 955097 955112 955140 955208 955244 955614 955715 955853 955859 955933 956047 956205 956397 956430 956436 956511 956634 956636 956735 956903 957112 957247 957564 957565 957608 957609 957799 958089 958303 958322 958452 958589 958628 958715 959230 959393 966072 966513 967232 I0577340 I576407 正常上限 正常下限 孕周 双顶径 2.5mU/L4治疗 TSH>4未治疗 孕周 双顶径 枕额径 21w 22w 23w 24w 25w 26w 27w 28w 29w 30w 0.25≤TSH≤2.5 70.67 69.52 73.04 75.43 80.67 85.33 91 92.67 97.5 98 2.54治疗 67.6 72.6 75.67 86 92 TSH>4未治疗 66.3 69.71 71.11 73.8 81 90.5 标准差0 2.983 4.063 4.876 4.49 3.786 6.11 6.028 0.707 11.314 标准差1 3.512 2.726 4.007 3.775 5.033 5.745 4.243 2.872 标准差2 4.561 2.977 4.243 4.243 2.828 标准差3 2.983 4.112 4.336 3.493 2.121 枕额径 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.25≤TSH≤2.5 2.54治疗 TSH>4未治疗 孕周 枕额径 枕额径 头围 21w 22w 23w 24w 25w 26w 27w 28w 29w 30w 31w 0.25≤TSH≤2.5 196.4 202.85 211.22 221.27 239.67 247 271 265.33 276.33 282 285.5 2.54治疗 195.6 208.11 215.5 245.5 268 292 TSH>4未治疗 192.5 202.71 207.4 215.8 212 226 256 280 标准差0 10.669 11.252 14.036 18.635 8.963 14.731 6.364 10.408 1.414 24.194 12.021 标准差1 14.012 8.96 12.341 7.097 13.528 19.687 4.646 标准差2 10.31 9.88 9.192 21.92 15.556 标准差3 17.678 7.387 8.562 6.979 4.243 头围 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.25≤TSH≤2.5 2.54治疗 TSH>4未治疗 孕周 头围 头围 肱骨长 21w 22w 23w 24w 25w 26w 27w 28w 29w 30w 31w 0.25≤TSH≤2.5 36 35.44 38.4 39.73 42.33 46 49 51.67 51 52.67 50 2.54治疗 35.2 37 38 43.5 48 53 TSH>4未治疗 34 36.14 36.91 38.4 40 41 47 62 标准差0 2.132 2.025 2.827 2.781 2.082 2 2.082 1.414 4.933 标准差1 4 2.188 3.163 1.581 2.517 2.872 0.707 2.517 标准差2 3.347 1.936 4.243 4.95 4.243 标准差3 1.414 1.676 0.894 2.881 0 肱骨长 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.25≤TSH≤2.5 2.54治疗 TSH>4未治疗 孕周 肱骨长 肱骨长 胎重 22w 23w 24w 25w 26w 27w 28w 29w 30w 31w 32w 33w 34w 35w 36w 37w 38w 39w 40w 41w 21w 0.25≤TSH≤2.5 550.61 612.35 714.88 844.17 1124 1080.8 1276.56 1597.67 1681.51 1882.9 2112.93 2279.2 2339.71 2709.35 2946.79 3155.5 3275.29 3432.38 3665.56 3635.2 682 2.54治疗 463 608.43 661 998 1288 1550.4 1740 1784.2 2397.33 2269.29 2351.5 3186 2909 3167.29 3309.17 3446 3445.4 3854.5 410 TSH>4未治疗 548.67 631.4 687.2 858 852 1211 1623 1620.67 1803 1958 1896 2045.33 2060 2618.8 2895 3011.43 3056.71 3443.83 3307.33 409 标准差0 128.596 174.206 122.559 80.248 213.07 121.436 169.117 232.163 269.369 313.583 276.219 415.385 208.567 336.103 337.773 337.019 386.455 278.339 76.169 69.236 标准差1 64.553 232.484 97.804 110.309 151.381 146.371 44.744 201.601 161.329 623.842 408.543 212.366 250.969 325.689 255.3 804.602 333.914 167.316 440.836 35.355 标准差2 70.071 76.774 151.321 28.284 145.664 171.14 154.213 90.163 208.904 204.354 346.277 247.374 251.731 377.507 414.9 223.238 218.496 标准差3 85.685 90.79 69.546 144.815 263.793 328.781 236.324 781.727 369.352 147.652 241.079 320.721 226.054 330.448 260.92 397.485 胎重 550.61 516.5 463 548.67 97.804 97.804 612.35 539.24 608.43 631.4 714.88 722.13 661 687.2 844.17 831 25w 858 1124 714.75 998 852 1080.8 886.5 27w 27w 1276.56 1183 1288 1211 1597.67 1433.75 1550.4 1623 1681.51 1533.69 1740 1620.67 1882.9 1870.86 1784.2 1803 2112.93 1800.89 2397.33 1958 2279.2 1965 2269.29 1896 2339.71 2339.33 2351.5 2045.33 2709.35 2586.17 3186 2060 2946.79 2821.76 2909 2618.8 3155.5 3020.71 3167.29 2895 3275.29 3184.15 3309.17 3011.43 3432.38 3333.59 3446 3056.71 3665.56 3447 3445.4 3443.83 3635.2 3551.33 3854.5 3307.33 0.25≤TSH≤2.5 2.54治疗 TSH>4未治疗 孕周 胎重 胎重 双顶径 S 腹左右径 28w 29w 30w 31w 32w 33w 34w 35w 36w 37w 38w 39w 40w 41w 0.25≤TSH≤2.5 76.67 81.57 84.33 88.65 92.75 93.8 94.46 99.24 102.64 104.36 107.84 107.63 111.89 111.33 2.54治疗 75 78 83.29 83.67 89.57 95 96.5 101.67 100.4 102.43 105.42 106.75 108.8 116 TSH>4未治疗 76 80.42 83.25 87.42 88.67 89.4 92.33 98.6 101 105.14 103.57 108.83 108 标准差0 3.67 4.791 4.933 5.334 6.123 3.882 7.601 3.903 5.131 7.009 5.691 5.391 4.886 2.49 标准差1 2.828 7.365 5.838 4.152 5.931 4.033 4.796 6.797 4.125 5.17 4.337 5.754 3.911 1.155 标准差2 3.651 3.094 4.619 4.992 7.024 3.536 5.859 2.881 2.76 5.534 7.394 3.701 1.414 标准差3 0 7.607 3.284 7.211 7.071 5.32 8.145 5.225 6.674 2.268 7.743 3.545 3.464 腹左右径 76.67 72 75 76 81.57 81.25 78 29w 84.33 82.95 83.29 80.42 88.65 87.26 83.67 83.25 92.75 89 89.57 87.42 93.8 89.67 95 88.67 94.46 91.5 96.5 89.4 99.24 96.25 101.67 92.33 102.64 100.55 100.4 98.6 104.36 103.21 102.43 101 107.84 106.18 105.42 105.14 107.63 107.12 106.75 103.57 111.89 109.25 108.8 108.83 111.33 107.8 116 108 0.25≤TSH≤2.5 2.54治疗 TSH>4未治疗 孕周 腹左右径 腹左右径 双顶径一 13w 14w 15w 16w 17w 21w 22w 23w 24w 25w 26w 27w 28w 29w 30w 31w 32w 33w 34w 35w 36w 37w 38w 39w 40w 41w 0.25≤TSH≤2.5 23.33 24.5 30.71 35 37 57 55.89 57.233 61.1 63.83 67.67 70.4 71.78 76.2 77.33 81.5 83.93 83.8 84.83 91.33 90.21 92.43 92.56 93.83 94.33 95.8 2.54治疗 30 35.33 38 55 58.111 60.2 68.5 72.67 75.5 78.29 81 84.75 82.43 86.5 88.47 91 93 92.92 94 94 96.5 TSH>4未治疗 24.5 30.5 34 34 50.7 55.63 57.2 58.5 62 62 70.5 77.67 78.7 81 77.67 83.5 85 87.8 91.92 92.14 91.86 91.83 92.67 标准差0 1.155 2.258 1.89 2.49 1.826 2.751 3.62 4.304 3.795 3.371 4.726 3.782 6.028 2.877 3.927 3.349 3.05 2.7 3.806 2.601 3.731 2.697 4.28 2.069 1.906 2.49 标准差1 1.5 3.271 2.708 0.5 2.646 2.204 3.3431 1.792 2.082 5 3.536 2.872 2.588 3.449 2.734 2.174 3.047 3.43 2.823 2.914 3.039 2.405 2.342 1.85 4.726 标准差2 4.243 0.577 1.414 3.606 3.333 4.95 6.364 2.828 3.512 3.45 2.236 1.708 6.658 0.707 3.055 1.528 2.828 1.379 2.449 1.414 2.121 标准差3 0.707 0.707 1.414 1.414 3.536 2.446 3.9623 3.962 2.121 3.011 3.713 1.732 11.899 4.037 6.557 3.347 2.109 3.132 5.113 3.011 2.082 双顶径一 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.25≤TSH≤2.5 2.54治疗 TSH>4未治疗 孕周 双顶径 胸径一 13w 14w 15w 16w 17w 21w 22w 23w 24w 25w 26w 27w 28w 0.25≤TSH≤2.5 18.5 19 23 26.3 28.17 47 47.28 48.04 52.3 52.5 58 59.2 60.33 2.54治疗 21.5 26 27.5 45.6 48.56 51 59.5 60.67 TSH>4未治疗 16 22 23.5 26 41.4 45.43 47.4 47.5 48 52 58.75 标准差0 1.414 3.651 3.564 2.584 2.483 2.914 4.677 4.196 3.907 3.674 3.606 4.324 2.121 标准差1 2.082 4.472 2.082 1.155 2.646 2.669 3.53 3.02 4 3.464 2.414 5.167 标准差2 2.121 4.95 2.881 3.206 2.121 6.364 2.309 标准差3 2.121 2.828 0.707 3.536 3.259 3.912 2.915 1.5 胸径一 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.25≤TSH≤2.5 2.54治疗 TSH>4未治疗 孕周 胸径 13周至28周胸径 腹径一 13w 14w 15w 16w 17w 21w 22w 23w 24w 25w 26w 27w 28w 0.25≤TSH≤2.5 23 30 31.33 34.33 38.5 57.67 58.04 59.25 62.18 66.17 77 74.8 80.33 2.54治疗 30 35 35.5 57.5 60.8 61 70 78.67 TSH>4未治疗 22 29.5 31 34 54.1 53.87 57.33 59.6 63 69 74.5 标准差0 5.965 2.16 2.398 2.429 4.508 5.063 5.62 4.283 3.061 5.292 8.289 5.431 标准差1 2.517 3.782 2.646 1.732 7.506 6.228 5.348 2.869 1.528 6.652 2.121 2.317 标准差2 5.657 6.364 2.121 3.421 3.606 7.071 4.423 1.155 标准差3 0.707 0.707 6.188 3.564 3.05 4.123 腹径一 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.25≤TSH≤2.5 2.54治疗 TSH>4未治疗 孕周 腹径 13周至28周腹径 腹围一 13w 14w 15w 16w 17w 21w 22w 23w 24w 25w 26w 27w 28w 0.25≤TSH≤2.5 68 77.5 97.67 108.09 116.71 178.67 183.19 193 190.32 209.83 223.67 224.8 243.44 2.54治疗 99 104.67 108.5 176 187.33 193.5 238 238 TSH>4未治疗 70.5 93.5 104.5 109 165.5 170.4 181 185 200 203 230.25 标准差0 6.245 7.503 5.955 9.354 9.656 11.689 23.967 18.246 22.569 6.178 12.662 4.324 15.589 标准差1 6.397 11.194 7.676 4.573 22.502 9.826 15.372 7.931 4.163 15.875 7.778 11.703 标准差2 26.87 5.859 2.121 9.889 11.587 14.849 16.971 17.349 标准差3 0.707 3.536 6.455 10.607 15.188 8.456 11.18 13.937 腹围一 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.25≤TSH≤2.5 2.54治疗 TSH>4未治疗 孕周 腹围 13周至28周腹围 股骨长一 13w 14w 15w 16w 17w 21w 22w 23w 24w 25w 26w 27w 28w 0.25≤TSH≤2.5 10.67 12.17 16.29 19.27 29 38.67 38.85 39.79 43.82 46.33 47 51.8 53.67 2.54治疗 15 20.33 22 37.8 40.4 42 48 52 TSH>4未治疗 9.5 16.5 16.5 20.5 34.9 37.75 39.22 40.8 42 45 50.67 标准差0 0.577 1.329 2.138 2.97 1.272 2.132 2.397 3.12 3.473 2 3.606 0.837 3.5 标准差1 2.062 3.421 1.732 1.472 2.517 2.504 3.104 1.633 2.082 3.304 1.414 3.141 标准差2 2.828 2.517 0.707 3.701 2.108 4.95 7.071 5.033 标准差3 0.707 0.707 1.708 2.828 3.536 2.55 0.894 2.588 2 股骨长一 0 0 0 0 2.138 2.138 3.421 3.421 2.828 2.828 0.707 0.707 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.25≤TSH≤2.5 2.54治疗 TSH>4未治疗 孕周 股骨长 13周至28周股骨长 双顶径二 29w 30w 31w 32w 33w 34w 35w 36w 37w 38w 39w 40w 41w 0.25≤TSH≤2.5 76.2 77.33 81.5 83.93 83.8 84.83 91.33 90.21 92.43 92.56 93.83 94.33 95.8 2.54治疗 75.5 78.29 81 84.75 82.43 86.5 88.47 91 93 92.92 94 94 96.5 TSH>4未治疗 77.67 78.7 81 77.67 83.5 85 87.8 91.92 92.14 91.86 91.83 92.67 标准差0 2.877 3.927 3.349 3.05 2.7 3.806 2.601 3.731 2.697 4.28 2.069 1.906 2.49 标准差1 2.588 3.449 2.734 2.174 3.047 3.43 2.823 2.914 3.039 2.405 2.342 1.85 4.726 标准差2 3.512 3.45 2.236 1.708 6.658 0.707 3.055 1.528 2.828 1.379 2.449 1.414 2.121 标准差3 3.011 3.713 1.732 11.899 4.037 6.557 3.347 2.109 3.132 5.113 3.011 2.082 双顶径二 76.2 75.56 75.5 29w 77.33 77.31 78.29 77.67 81.5 81.14 81 78.7 83.93 83 84.75 81 83.8 78.75 82.43 77.67 84.83 84.21 86.5 83.5 91.33 87.83 88.47 85 90.21 89.33 91 87.8 92.43 91.33 93 91.92 92.56 92.32 92.92 92.14 93.83 92.88 94 91.86 94.33 93.89 94 91.83 95.8 93.33 96.5 92.67 0.25≤TSH≤2.5 2.54治疗 TSH>4未治疗 孕周 双顶径 29周至41周双顶径 胸径二 29w 30w 31w 32w 33w 34w 35w 36w 37w 38w 39w 40w 41w 0.25≤TSH≤2.5 64.33 66.78 72.19 74.64 72.1 75.17 78.71 81 81.15 81.47 81.93 83.17 82 2.54治疗 64.5 67 70.8 73 71 72.5 81.69 79.13 82.29 83.17 81.88 84.4 81.5 TSH>4未治疗 66.83 68.33 70.58 67.25 71.83 75.67 78 80 80.29 80.86 81 79.67 标准差0 2.958 4.577 2.96 3.003 3.665 4.201 3.771 3.771 3.541 4.58 2.586 2.995 4.278 标准差1 3.435 4.059 3.599 3.175 3.367 4.021 4.452 4.452 3.864 3.025 2.781 1.907 3.606 标准差2 3 4.655 3.194 2.363 2.646 3.536 4.726 2.582 2.87 3.129 1 3.209 0.707 标准差3 3.971 3.122 1.732 9.142 2.927 6.028 3.674 5.939 3.147 4.375 3.204 1.528 胸径二 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.25≤TSH≤2.5 2.54治疗 TSH>4未治疗 孕周 胸径 29周至41周胸径 腹径二 29w 30w 31w 32w 33w 34w 35w 36w 37w 38w 39w 40w 41w 0.25≤TSH≤2.5 83.56 82.38 91.14 92.07 94.5 95.64 100.59 103.79 106.05 109.37 110.13 112.89 110.4 2.54治疗 79.25 84.29 88.2 95.75 95.86 96.17 107 101.34 104.14 108.25 109 111.33 119.5 TSH>4未治疗 81 85.33 88.33 84.75 92.17 91.67 99 102.67 106.86 105.57 109.33 110.33 标准差0 4.586 5.284 5.206 4.843 4.625 7.702 4.501 4.682 6.139 5.188 5.438 4.575 2.608 标准差1 6.38 3.32 5.699 3.467 7.988 5.879 4.313 4.423 3.933 6.26 4.619 8.737 标准差2 3.202 2.87 1.924 4.349 5.859 7.778 4.501 5.956 2.854 6.96 7.394 5.675 0.707 标准差3 6.45 6.837 7.506 14.975 8.998 7.638 8.093 4.499 2.795 6.63 3.266 9.074 腹径二 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.25≤TSH≤2.5 2.54治疗 TSH>4未治疗 孕周 腹径 29周至41周腹径 腹围二 29w 30w 31w 32w 33w 34w 35w 36w 37w 38w 39w 40w 41w 0.25≤TSH≤2.5 264.44 265.67 277.23 287.36 296.6 300.79 314.65 327.07 332.68 339.32 342.4 354.33 356.6 2.54治疗 249.5 264.43 269.6 281.25 294.86 301.83 327.33 320.57 334 342.79 343 350.67 373.5 TSH>4未治疗 254.74 272.78 281 268.5 289 297 320.2 320.5 334.57 329.14 341.67 343 标准差0 12.156 38.034 15.449 17.596 13.664 22.168 11.346 14.465 19.074 15.988 17.694 14.025 6.914 标准差1 23.965 12.399 10.111 14.856 19.718 13.992 14.878 13.51 12.728 12.608 16.954 10.899 14.844 标准差2 13.796 7.044 9.555 42.836 11.015 19.799 15.011 14.14 8.287 17.243 18.348 11.777 3.536 标准差3 22.774 18.866 22.539 42.067 16.125 14.731 14.533 18.933 10.454 15.742 8.042 19.925 腹围二 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.25≤TSH≤2.5 2.54治疗 TSH>4未治疗 孕周 腹围 29周至41周腹围 股骨长二 29w 30w 31w 32w 33w 34w 35w 36w 37w 38w 39w 40w 41w 0.25≤TSH≤2.5 55.56 57.23 60.55 61.43 64.4 65.71 67.82 69.93 70.7 72.06 73 74.11 75 2.54治疗 53.25 56.29 59.71 64 61.14 64.67 70.57 71.05 73.43 74 73.75 77.5 TSH>4未治疗 56.67 58.8 60.67 56.25 63 68 69.08 71.83 68.14 72.17 73.67 标准差0 2.789 3.442 2.988 2.138 2.366 4.762 4.762 8.7 2.399 2.616 2.56 2.374 1.581 标准差1 4.506 2.94 2.215 2.29 3.388 2.563 2.146 1.94 1.987 2.182 2.398 2.137 1 标准差2 2.5 1.496 2.168 4.243 2.082 1.414 2.637 2.854 1.946 2.944 1.643 0.707 标准差3 2.066 4.3676 1.155 13.074 2.16 2.739 3.476 0.976 7.647 1.169 1.155 股骨长二 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.25≤TSH≤2.5 2.54治疗 TSH>4未治疗 孕周 股骨长 29周41周股骨长 Chart2 83.93 83 84.75 81 全 甲功分组 13w 14w 15w 16w 17w 18w 19w 20w 21w 22w 23w 24w 25w 26w 27w 28w 29w 30w 31w 32w 33w 34w 35w 36w 37w 38w 39w 40w 41w 947522 0 35 948157 0 28 948159 0 40 948237 0 37 948360 0 49 948362 0 52 948366 0 24 948741 0 38 948935 0 24 59 948958 0 33 953977 0 45 954088 0 30 954542 0 21 954661 0 32 954809 0 33 955157 0 31 955513 0 22 955631 0 35 955929 0 36 956117 0 39 956777 0 40 956986 0 25 957001 0 28 957064 0 32 957166 0 38 958162 0 34 958183 0 24 958845 0 34 959113 0 31 965282 0 38 966394 0 40 966467 0 36 966892 0 33 967020 0 25 29 967069 0 36 967072 0 24 I0576727 0 36 955792 0 50 955921 0 56 956849 0 55 948157 0 49 948460 0 50 948487 0 49 949063 0 48 958413 0 49 965865 0 52 966833 0 49 953512 0 50 952690 0 56 954088 0 56 954403 0 52 955490 0 53 954542 0 54 954870 0 55 956118 0 56 954693 0 54 957001 0 53 956959 0 59 956986 0 55 955961 0 58 956902 0 62 956582 0 56 956807 0 60 I0576843 0 51 I0576714 0 58 I0576727 0 59 957498 0 55 948159 0 66 957716 0 59 948936 0 53 967072 0 57 965587 0 53 966530 0 58 965667 0 51 953291 0 56 954661 0 53 954948 0 58 955929 0 60 954809 0 64 956337 0 60 956958 0 54 957166 0 60 956816 0 63 I0576796 0 54 I0576618 0 62 948237 0 64 948410 0 47 948133 0 59 958162 0 55 948603 0 58 958413 0 54 958845 0 59 959113 0 53 959136 0 55 958845 0 59 958183 0 57 967020 0 52 966945 0 61 953359 0 56 954938 0 59 955254 0 60 955157 0 65 954659 0 61 955769 0 53 955057 0 59 957064 0 59 956117 0 59 955254 0 60 947522 0 55 948455 0 50 956706 0 58 948366 0 60 948958 0 62 948741 0 66 958691 0 62 966394 0 55 966546 0 58 965282 0 62 967069 0 63 I0577403 0 62 955631 0 66 955564 0 58 I0576712 0 64 956777 0 66 958162 0 67 958183 0 62 956119 0 73 957143 0 64 958573 0 66 953977 0 73 956849 0 73 957013 0 64 I0576796 0 70 I0576859 0 72 953512 0 70 954693 0 68 I0576714 0 73 956709 0 74 957199 0 72 957196 0 72 948286 0 71 966892 0 73 967096 0 73 956164 0 80 957973 0 78 957232 0 77 957522 0 72 948655 0 71 957714 0 77 965865 0 74 I0577403 0 75 966530 0 76 953512 0 71 953291 0 76 954088 0 82 954403 0 78 954542 0 74 954948 0 80 954870 0 78 955254 0 78 956463 0 74 956118 0 79 954693 0 78 955792 0 79 955769 0 75 955921 0 78 955631 0 82 956337 0 77 956812 0 79 956986 0 76 956639 0 63 955254 0 78 956902 0 78 956582 0 73 956816 0 79 I0576843 0 72 I0576712 0 78 I0576727 0 77 948178 0 75 956943 0 77 948159 0 88 948133 0 79 948387 0 71 948360 0 80 948460 0 72 948487 0 79 948603 0 82 948958 0 77 948936 0 79 948935 0 84 958845 0 78 959113 0 74 958845 0 78 967020 0 77 966546 0 78 967072 0 80 967069 0 81 966833 0 76 952690 0 83 953359 0 81 954014 0 75 956040 0 82 956046 0 83 954893 0 76 954809 0 85 955157 0 83 955057 0 82 956959 0 84 957166 0 83 I0576796 0 77 I0576618 0 89 948157 0 80 956777 0 84 958162 0 77 948362 0 81 958413 0 74 958573 0 81 966394 0 84 966467 0 76 965282 0 85 953512 0 78 954661 0 84 955836 0 86 956958 0 79 957001 0 84 957064 0 76 956117 0 83 955961 0 82 956807 0 86 948237 0 88 957716 0 85 948741 0 84 949063 0 85 966945 0 89 954938 0 80 954948 0 87 957862 0 85 955836 0 86 948133 0 85 958691 0 80 959136 0 84 965587 0 87 965730 0 81 965667 0 83 952131 0 82 955490 0 83 955254 0 84 954659 0 88 955721 0 84 956986 0 86 957024 0 88 955254 0 84 957583 0 87 947522 0 77 948455 0 76 955935 0 87 957716 0 85 I0576859 0 88 953291 0 86 952690 0 88 955929 0 90 955921 0 88 956849 0 90 956959 0 92 955721 0 84 957143 0 84 I0576843 0 85 I0576712 0 91 I0576714 0 90 947522 0 82 948366 0 87 959136 0 88 966892 0 88 965587 0 91 I0577403 0 90 966530 0 92 952131 0 85 953551 0 86 954440 0 90 953977 0 88 954870 0 90 956119 0 94 955792 0 91 955646 0 82 955057 0 93 956812 0 92 957064 0 85 954864 0 88 956582 0 89 I0576796 0 91 I0576618 0 96 I0576727 0 92 948157 0 87 955697 0 82 956943 0 90 948133 0 92 948362 0 87 948487 0 90 948645 0 93 948935 0 96 949046 0 90 959113 0 87 959328 0 81 965888 0 93 966394 0 91 967096 0 91 967072 0 91 966807 0 89 966833 0 86 953512 0 91 953359 0 92 954938 0 89 954948 0 86 954893 0 90 955929 0 94 954809 0 96 956118 0 91 954693 0 83 955157 0 91 955769 0 93 955245 0 90 956337 0 91 956958 0 89 956812 0 91 957166 0 94 956117 0 93 956902 0 92 956816 0 92 956807 0 95 948237 0 93 958162 0 91 I0576859 0 93 948362 0 85 948360 0 93 948460 0 89 948741 0 94 958845 0 93 958691 0 89 959121 0 91 958845 0 93 958183 0 90 957902 0 92 958573 0 91 967020 0 90 966546 0 92 965282 0 95 966945 0 96 967069 0 91 965865 0 93 952131 0 90 953291 0 91 954088 0 98 954403 0 90 955490 0 89 954661 0 90 954938 0 90 954809 0 93 956118 0 89 954693 0 88 957001 0 90 956959 0 92 956986 0 93 957166 0 94 956639 0 72 955961 0 93 956582 0 91 956807 0 95 I0576843 0 90 I0576618 0 97 I0576712 0 95 I0576727 0 95 948157 0 91 948133 0 90 956777 0 95 948360 0 95 948603 0 94 958691 0 88 959092 0 94 957714 0 94 966546 0 92 966467 0 93 967096 0 92 967072 0 90 954014 0 95 954542 0 93 954870 0 94 955254 0 90 955929 0 94 954917 0 956119 0 96 955792 0 94 954659 0 94 955921 0 94 955631 0 95 956940 0 95 956335 0 955254 0 90 956902 0 91 956816 0 94 I0576843 0 92 948237 0 95 948178 0 95 948159 0 100 948366 0 94 948958 0 96 948936 0 94 959136 0 97 958183 0 91 957902 0 95 958573 0 93 967020 0 92 966394 0 94 966892 0 93 965667 0 93 952690 0 91 953701 0 92 954014 0 92 953977 0 93 954870 0 94 955631 0 96 956849 0 96 956902 0 92 957143 0 94 957843 0 98 948936 0 94 958845 0 95 958398 0 94 958845 0 95 957714 0 96 958573 0 91 965865 0 93 965667 0 94 953701 0 93 954542 0 92 957001 0 95 948958 0 95 965865 0 89 944130 1 37 948244 1 31 948352 1 26 948496 1 31 953808 1 37 953944 1 37 954248 1 38 955097 1 30 955208 1 37 955853 1 37 955933 1 32 956903 1 27 957247 1 32 957608 1 27 958089 1 49 958303 1 24 958452 1 34 958589 1 24 958691 1 32 966072 1 35 967232 1 26 I576407 1 60 951613 1 55 949080 1 56 953808 1 55 956735 1 56 956812 1 56 956903 1 58 947733 1 51 948352 1 53 966513 1 54 967232 1 53 953550 1 61 953432 1 56 954248 1 57 944130 1 58 955853 1 62 955097 1 54 955921 1 58 956511 1 49 957608 1 57 957564 1 59 957247 1 60 948244 1 59 957799 1 56 959393 1 58 958589 1 61 958628 1 51 958303 1 57 966072 1 59 953296 1 63 955244 1 60 955140 1 59 955933 1 58 957565 1 63 956634 1 61 956511 1 63 956436 1 60 948558 1 62 I0577340 1 62 955208 1 65 959393 1 62 967232 1 61 953531 1 63 958088 1 63 948496 1 53 958452 1 63 948385 1 67 959230 1 62 954013 1 72 955112 1 70 955715 1 72 957361 1 68 956205 1 72 957609 1 76 951613 1 75 955853 1 80 956735 1 77 948385 1 73 958089 1 76 953550 1 81 953944 1 81 953808 1 79 955933 1 72 955921 1 81 956436 1 76 956903 1 81 948244 1 78 947733 1 76 958322 1 75 948352 1 75 958628 1 71 957539 1 79 953432 1 79 954248 1 80 944130 1 81 957565 1 83 958589 1 85 966513 1 77 966072 1 83 953296 1 79 955208 1 85 955859 1 78 955140 1 81 955097 1 81 956047 1 81 957608 1 82 948496 1 80 949045 1 86 959393 1 85 959230 1 79 958303 1 81 954001 1 83 953531 1 83 956634 1 83 956511 1 85 957564 1 85 957799 1 76 965596 1 82 I576407 1 83 953944 1 86 955244 1 88 953227 1 79 955853 1 88 957799 1 85 951613 1 89 953296 1 88 953432 1 91 955057 1 84 956205 1 86 956436 1 86 955614 1 86 948558 1 86 958452 1 87 958089 1 93 966513 1 86 966072 1 92 I576407 1 88 955140 1 91 953227 1 86 955933 1 86 956735 1 92 957112 1 89 956397 1 96 948244 1 89 958322 1 91 949080 1 91 959393 1 90 958723 1 95 966513 1 91 967232 1 88 954011 1 92 953550 1 93 954248 1 88 953808 1 94 953531 1 91 955208 1 96 953227 1 86 955097 1 92 957565 1 95 956634 1 88 956511 1 92 956636 1 92 956903 1 91 957247 1 95 948385 1 89 948352 1 88 948496 1 91 949080 1 95 958589 1 95 958628 1 88 958303 1 87 I576407 1 91 951613 1 944130 1 92 954013 1 90 955853 1 98 955933 1 91 955921 1 92 955057 1 91 956735 1 94 956397 1 98 956436 1 93 957608 1 90 957564 1 94 948244 1 92 947733 1 90 957799 1 95 958715 1 91 967232 1 92 965596 1 91 966072 1 95 954011 1 94 953944 1 95 953808 1 93 954013 1 91 955853 1 96 955097 1 94 956430 1 88 956634 1 92 956205 1 90 956636 1 93 956436 1 93 I0576714 1 94 958322 1 97 948385 1 95 948352 1 91 958452 1 93 959230 1 90 953432 1 91 954248 1 90 944130 1 93 956735 1 94 957064 1 91 957565 1 96 956205 1 91 957608 1 92 948763 1 90 959121 1 93 958628 1 90 958303 1 91 953944 1 97 956636 1 95 948558 1 88 955794 2 33 956676 2 37 956945 2 35 956953 2 27 957945 2 36 958834 2 39 965911 2 35 956905 2 56 948979 2 55 955165 2 60 965796 2 50 965596 2 54 955794 2 56 954949 2 53 954965 2 58 956945 2 60 956676 2 61 956953 2 55 957945 2 64 967726 2 57 965911 2 59 I0576715 2 55 958834 2 62 955875 2 73 955115 2 64 956091 2 74 956022 2 72 954556 2 72 955514 2 73 957945 2 79 948979 2 78 956091 2 81 955794 2 76 956676 2 81 I0576715 2 77 955165 2 81 965796 2 72 965596 2 80 949806 2 84 954965 2 78 956905 2 81 949005 2 80 965911 2 82 956945 2 85 955643 2 87 947195 2 84 958834 2 83 954949 2 82 965796 2 70 967726 2 81 954965 2 87 I0576715 2 86 967726 2 956091 2 88 956022 2 92 956509 2 94 952530 2 93 949806 2 92 955794 2 89 956953 2 89 957945 2 91 948979 2 92 955165 2 91 949806 2 96 955875 2 94 955532 2 91 956953 2 88 965596 2 96 967726 2 93 965911 2 93 956022 2 95 954949 2 93 954965 2 92 956945 2 96 956905 2 91 957945 2 93 948979 2 93 949108 2 94 949005 2 92 958834 2 96 965796 2 89 967726 2 93 956945 2 96 956676 2 93 965596 2 96 965911 2 91 954949 2 92 954965 2 95 957945 2 93 949005 2 95 955165 2 95 952530 2 98 955165 2 95 951819 3 44 954606 3 30 954831 3 33 955093 3 33 956116 3 35 956653 3 25 957984 3 34 966329 3 31 966517 3 24 967322 3 33 I0576797 3 36 957984 3 56 948839 3 51 948276 3 60 I0576540 3 56 954831 3 53 955927 3 58 956653 3 53 948613 3 56 966329 3 54 967084 3 55 952241 3 58 955093 3 58 956907 3 57 956116 3 51 956336 3 62 957250 3 58 I0576797 3 65 949064 3 57 967301 3 57 967322 3 64 957031 3 62 948747 3 68 954606 3 71 I0576540 3 75 957226 3 73 957165 3 71 956907 3 72 956116 3 74 957250 3 77 I0576797 3 82 957984 3 80 966329 3 75 967084 3 78 948276 3 75 955093 3 80 954831 3 77 956653 3 75 957250 3 78 956736 3 78 948337 3 88 948604 3 80 949064 3 79 967301 3 77 955927 3 81 948839 3 84 967322 3 84 956336 3 85 955897 3 86 948699 3 83 966517 3 61 954606 3 84 956907 3 80 957234 3 83 956116 3 80 I0576797 3 91 948239 3 83 954554 3 79 948276 3 84 966517 3 92 956907 3 82 957984 3 89 948604 3 90 966329 3 90 967301 3 88 952241 3 90 955093 3 94 I0576540 3 94 956653 3 88 957250 3 92 948239 3 90 948730 3 90 948839 3 94 949064 3 94 949054 3 94 967084 3 91 967322 3 92 955093 3 93 955927 3 89 956653 3 89 I0576797 3 96 949054 3 94 966329 3 91 967322 3 95 956116 3 86 956336 3 93 948239 3 90 948839 3 95 958527 3 85 966517 3 95 967322 3 99 952241 3 93 954606 3 91 I0576540 3 97 957250 3 97 957984 3 97 967301 3 91 948276 3 91 954606 3 90 957250 3 94 956096 4 35 965446 4 35 959072 4 50 967056 4 55 955328 4 67 957442 4 52 965446 4 59 956096 4 70 959072 4 73 957442 4 78 967056 4 80 955328 4 83 954915 4 78 965446 4 80 957442 4 92 955328 4 94 959072 4 91 967056 4 88 955787 4 92 956096 4 90 959072 4 93 967056 4 93 965446 4 91 955328 4 94 955874 5 39 956277 5 38 958114 5 31 958685 5 27 958868 5 34 958192 5 56 958588 5 59 958114 5 56 966937 5 54 958868 5 51 958685 5 59 955874 5 67 956277 5 66 948260 5 72 958868 5 74 958588 5 78 966937 5 74 958685 5 78 958114 5 81 956277 5 84 957469 5 80 948260 5 86 958192 5 86 966937 5 93 958032 5 87 958868 5 86 958588 5 95 958114 5 92 958588 5 97 958685 5 94 956277 5 95 958192 5 92 948260 5 96 958868 5 93 948260 5 94 958192 5 95 965665 6 26 966220 6 25 957546 6 58 965665 6 54 966220 6 53 958019 6 66 966220 6 74 957546 6 81 965665 6 81 958019 6 85 965665 6 86 957546 6 90 965665 6 92 966220 6 89 957546 6 95 958019 6 94 前四组 甲功分组 13w 14w 15w 16w 17w 18w 19w 20w 21w 22w 23w 24w 25w 26w 27w 28w 29w 30w 31w 32w 33w 34w 35w 36w 37w 38w 39w 40w 41w 947522 0 35 55 77 82 948157 0 28 49 80 87 91 948159 0 40 66 88 100 948178 0 75 95 948237 0 37 64 88 93 95 948360 0 49 80 948362 0 52 81 87 85 948366 0 24 60 87 94 948455 0 50 76 948460 0 50 72 89 948487 0 49 79 90 948603 0 58 82 94 948741 0 38 66 84 94 948935 0 24 59 84 96 948936 0 53 79 94 94 948958 0 33 62 77 96 95 949046 0 90 949063 0 48 85 952131 0 82 85 90 952690 0 56 83 88 91 953291 0 56 76 86 91 953359 0 56 81 92 953512 0 50 70 71 78 91 953551 0 86 953701 0 92 93 953977 0 45 73 88 93 954014 0 75 95 92 954088 0 30 56 82 98 954403 0 52 78 90 954440 0 90 954542 0 21 54 74 93 92 954659 0 61 88 94 954661 0 32 53 84 90 954693 0 54 68 78 83 88 954693 0 68 954809 0 33 64 85 96 93 954864 0 88 954870 0 55 78 90 94 94 954893 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0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 #REF! 948157 948159 948178 948237 948360 948362 948366 #REF! 948460 948487 948603 948741 948935 948936 948958 949046 949063 952131 952690 953291 953359 953512 953551 953701 953977 954014 954088 954403 954440 954542 954659 954661 #REF! 954693 954809 954864 954870 954893 954917 954938 954948 955057 955157 955245 955254 955490 955513 955564 955631 955646 955721 955769 955792 955836 955921 955929 955935 955961 956040 956046 956117 956118 956119 956335 956337 956463 956582 #REF! 956706 956709 956777 956807 956812 956816 956849 956902 956940 956943 956958 956959 956986 957001 957013 957024 957064 957143 957166 957232 957714 957716 957902 958162 958183 958413 958573 958691 958845 959113 959121 959136 #REF! 965282 965587 965667 965865 965888 966394 966530 966546 966807 966833 966892 966945 967020 967069 967072 967096 I0576618 I0576712 I0576714 I0576727 I0576796 I0576843 I0576859 I0577403 正常上限 正常下限 孕周 双顶径 正常对照组孕妇胎儿双顶径变化 第三组 20w 21w 22w 23w 24w 25w 26w 27w 28w 29w 30w 31w 32w 33w 34w 35w 36w 37w 38w 39w 40w 41w 甲功分组 944130 58 81 92 93 1 947733 51 59 79 85 92 90 1 948244 59 78 89 92 1 948352 53 75 88 91 1 948385 67 73 89 95 1 948496 53 80 91 1 948558 62 86 88 1 949045 86 1 949080 56 91 95 1 951613 55 75 89 1 953227 79 86 86 1 953296 63 79 88 1 953432 56 79 91 91 1 953531 63 83 91 1 953550 61 81 93 1 953808 55 79 94 93 1 953944 81 86 95 96 1 954001 83 1 954011 92 94 1 954013 72 90 91 1 954248 57 80 88 90 1 955097 54 81 92 94 1 955112 70 1 955140 59 81 91 1 955208 65 85 96 1 955244 60 88 1 955614 86 1 955715 72 1 955853 62 80 88 98 96 1 955859 78 1 955933 58 72 86 91 1 956047 81 1 956205 72 86 90 91 1 956397 96 98 1 956430 88 1 956436 60 76 86 93 93 1 956511 49 63 85 92 1 956634 61 83 88 92 1 956636 92 93 95 1 956735 56 77 92 94 94 1 956903 58 81 91 1 957112 89 1 957247 60 95 1 957564 59 85 94 1 957565 63 83 95 96 1 957608 57 82 90 92 1 957609 76 1 957799 56 76 85 95 1 958089 49 76 93 1 958303 57 81 87 91 1 958322 75 91 97 1 958452 63 87 93 1 958589 61 85 95 1 958628 51 71 88 90 1 958715 91 1 959230 62 79 90 1 959393 58 62 85 90 1 966072 59 83 92 95 1 966513 54 77 86 91 1 967232 53 61 88 92 1 I0577340 62 1 I576407 60 83 88 91 1 正常上限 62 97 97 正常下限 54 84 第三组 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 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0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 944130 947733 948244 948352 948385 948496 948558 949045 949080 951613 953227 953296 953432 953531 953550 953808 953944 954001 954011 954013 954248 955097 955112 955140 955208 955244 955614 955715 955853 955859 955933 956047 956205 956397 956430 956436 956511 956634 956636 956735 956903 957112 957247 957564 957565 957608 957609 957799 958089 958303 958322 958452 958589 958628 958715 959230 959393 966072 966513 967232 I0577340 I576407 正常上限 正常下限 孕周 双顶径 2.5mU/L4治疗 TSH>4未治疗 孕周 双顶径 枕额径 21w 22w 23w 24w 25w 26w 27w 28w 29w 30w 0.25≤TSH≤2.5 70.67 69.52 73.04 75.43 80.67 85.33 91 92.67 97.5 98 2.54治疗 67.6 72.6 75.67 86 92 TSH>4未治疗 66.3 69.71 71.11 73.8 81 90.5 标准差0 2.983 4.063 4.876 4.49 3.786 6.11 6.028 0.707 11.314 标准差1 3.512 2.726 4.007 3.775 5.033 5.745 4.243 2.872 标准差2 4.561 2.977 4.243 4.243 2.828 标准差3 2.983 4.112 4.336 3.493 2.121 枕额径 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.25≤TSH≤2.5 2.54治疗 TSH>4未治疗 孕周 枕额径 枕额径 头围 21w 22w 23w 24w 25w 26w 27w 28w 29w 30w 31w 0.25≤TSH≤2.5 196.4 202.85 211.22 221.27 239.67 247 271 265.33 276.33 282 285.5 2.54治疗 195.6 208.11 215.5 245.5 268 292 TSH>4未治疗 192.5 202.71 207.4 215.8 212 226 256 280 标准差0 10.669 11.252 14.036 18.635 8.963 14.731 6.364 10.408 1.414 24.194 12.021 标准差1 14.012 8.96 12.341 7.097 13.528 19.687 4.646 标准差2 10.31 9.88 9.192 21.92 15.556 标准差3 17.678 7.387 8.562 6.979 4.243 头围 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.25≤TSH≤2.5 2.54治疗 TSH>4未治疗 孕周 头围 头围 肱骨长 21w 22w 23w 24w 25w 26w 27w 28w 29w 30w 31w 0.25≤TSH≤2.5 36 35.44 38.4 39.73 42.33 46 49 51.67 51 52.67 50 2.54治疗 35.2 37 38 43.5 48 53 TSH>4未治疗 34 36.14 36.91 38.4 40 41 47 62 标准差0 2.132 2.025 2.827 2.781 2.082 2 2.082 1.414 4.933 标准差1 4 2.188 3.163 1.581 2.517 2.872 0.707 2.517 标准差2 3.347 1.936 4.243 4.95 4.243 标准差3 1.414 1.676 0.894 2.881 0 肱骨长 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.25≤TSH≤2.5 2.54治疗 TSH>4未治疗 孕周 肱骨长 肱骨长 胎重 22w 23w 24w 25w 26w 27w 28w 29w 30w 31w 32w 33w 34w 35w 36w 37w 38w 39w 40w 41w 21w 0.25≤TSH≤2.5 550.61 612.35 714.88 844.17 1124 1080.8 1276.56 1597.67 1681.51 1882.9 2112.93 2279.2 2339.71 2709.35 2946.79 3155.5 3275.29 3432.38 3665.56 3635.2 682 2.54治疗 463 608.43 661 998 1288 1550.4 1740 1784.2 2397.33 2269.29 2351.5 3186 2909 3167.29 3309.17 3446 3445.4 3854.5 410 TSH>4未治疗 548.67 631.4 687.2 858 852 1211 1623 1620.67 1803 1958 1896 2045.33 2060 2618.8 2895 3011.43 3056.71 3443.83 3307.33 409 标准差0 128.596 174.206 122.559 80.248 213.07 121.436 169.117 232.163 269.369 313.583 276.219 415.385 208.567 336.103 337.773 337.019 386.455 278.339 76.169 69.236 标准差1 64.553 232.484 97.804 110.309 151.381 146.371 44.744 201.601 161.329 623.842 408.543 212.366 250.969 325.689 255.3 804.602 333.914 167.316 440.836 35.355 标准差2 70.071 76.774 151.321 28.284 145.664 171.14 154.213 90.163 208.904 204.354 346.277 247.374 251.731 377.507 414.9 223.238 218.496 标准差3 85.685 90.79 69.546 144.815 263.793 328.781 236.324 781.727 369.352 147.652 241.079 320.721 226.054 330.448 260.92 397.485 胎重 550.61 516.5 463 548.67 97.804 97.804 612.35 539.24 608.43 631.4 714.88 722.13 661 687.2 844.17 831 25w 858 1124 714.75 998 852 1080.8 886.5 27w 27w 1276.56 1183 1288 1211 1597.67 1433.75 1550.4 1623 1681.51 1533.69 1740 1620.67 1882.9 1870.86 1784.2 1803 2112.93 1800.89 2397.33 1958 2279.2 1965 2269.29 1896 2339.71 2339.33 2351.5 2045.33 2709.35 2586.17 3186 2060 2946.79 2821.76 2909 2618.8 3155.5 3020.71 3167.29 2895 3275.29 3184.15 3309.17 3011.43 3432.38 3333.59 3446 3056.71 3665.56 3447 3445.4 3443.83 3635.2 3551.33 3854.5 3307.33 0.25≤TSH≤2.5 2.54治疗 TSH>4未治疗 孕周 胎重 胎重 双顶径 S 腹左右径 28w 29w 30w 31w 32w 33w 34w 35w 36w 37w 38w 39w 40w 41w 0.25≤TSH≤2.5 76.67 81.57 84.33 88.65 92.75 93.8 94.46 99.24 102.64 104.36 107.84 107.63 111.89 111.33 2.54治疗 75 78 83.29 83.67 89.57 95 96.5 101.67 100.4 102.43 105.42 106.75 108.8 116 TSH>4未治疗 76 80.42 83.25 87.42 88.67 89.4 92.33 98.6 101 105.14 103.57 108.83 108 标准差0 3.67 4.791 4.933 5.334 6.123 3.882 7.601 3.903 5.131 7.009 5.691 5.391 4.886 2.49 标准差1 2.828 7.365 5.838 4.152 5.931 4.033 4.796 6.797 4.125 5.17 4.337 5.754 3.911 1.155 标准差2 3.651 3.094 4.619 4.992 7.024 3.536 5.859 2.881 2.76 5.534 7.394 3.701 1.414 标准差3 0 7.607 3.284 7.211 7.071 5.32 8.145 5.225 6.674 2.268 7.743 3.545 3.464 腹左右径 76.67 72 75 76 81.57 81.25 78 29w 84.33 82.95 83.29 80.42 88.65 87.26 83.67 83.25 92.75 89 89.57 87.42 93.8 89.67 95 88.67 94.46 91.5 96.5 89.4 99.24 96.25 101.67 92.33 102.64 100.55 100.4 98.6 104.36 103.21 102.43 101 107.84 106.18 105.42 105.14 107.63 107.12 106.75 103.57 111.89 109.25 108.8 108.83 111.33 107.8 116 108 0.25≤TSH≤2.5 2.54治疗 TSH>4未治疗 孕周 腹左右径 腹左右径 双顶径一 13w 14w 15w 16w 17w 21w 22w 23w 24w 25w 26w 27w 28w 29w 30w 31w 32w 33w 34w 35w 36w 37w 38w 39w 40w 41w 0.25≤TSH≤2.5 23.33 24.5 30.71 35 37 57 55.89 57.233 61.1 63.83 67.67 70.4 71.78 76.2 77.33 81.5 83.93 83.8 84.83 91.33 90.21 92.43 92.56 93.83 94.33 95.8 2.54治疗 30 35.33 38 55 58.111 60.2 68.5 72.67 75.5 78.29 81 84.75 82.43 86.5 88.47 91 93 92.92 94 94 96.5 TSH>4未治疗 24.5 30.5 34 34 50.7 55.63 57.2 58.5 62 62 70.5 77.67 78.7 81 77.67 83.5 85 87.8 91.92 92.14 91.86 91.83 92.67 标准差0 1.155 2.258 1.89 2.49 1.826 2.751 3.62 4.304 3.795 3.371 4.726 3.782 6.028 2.877 3.927 3.349 3.05 2.7 3.806 2.601 3.731 2.697 4.28 2.069 1.906 2.49 标准差1 1.5 3.271 2.708 0.5 2.646 2.204 3.3431 1.792 2.082 5 3.536 2.872 2.588 3.449 2.734 2.174 3.047 3.43 2.823 2.914 3.039 2.405 2.342 1.85 4.726 标准差2 4.243 0.577 1.414 3.606 3.333 4.95 6.364 2.828 3.512 3.45 2.236 1.708 6.658 0.707 3.055 1.528 2.828 1.379 2.449 1.414 2.121 标准差3 0.707 0.707 1.414 1.414 3.536 2.446 3.9623 3.962 2.121 3.011 3.713 1.732 11.899 4.037 6.557 3.347 2.109 3.132 5.113 3.011 2.082 双顶径一 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.25≤TSH≤2.5 2.54治疗 TSH>4未治疗 孕周 双顶径 胸径一 13w 14w 15w 16w 17w 21w 22w 23w 24w 25w 26w 27w 28w 0.25≤TSH≤2.5 18.5 19 23 26.3 28.17 47 47.28 48.04 52.3 52.5 58 59.2 60.33 2.54治疗 21.5 26 27.5 45.6 48.56 51 59.5 60.67 TSH>4未治疗 16 22 23.5 26 41.4 45.43 47.4 47.5 48 52 58.75 标准差0 1.414 3.651 3.564 2.584 2.483 2.914 4.677 4.196 3.907 3.674 3.606 4.324 2.121 标准差1 2.082 4.472 2.082 1.155 2.646 2.669 3.53 3.02 4 3.464 2.414 5.167 标准差2 2.121 4.95 2.881 3.206 2.121 6.364 2.309 标准差3 2.121 2.828 0.707 3.536 3.259 3.912 2.915 1.5 胸径一 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.25≤TSH≤2.5 2.54治疗 TSH>4未治疗 孕周 胸径 13周至28周胸径 腹径一 13w 14w 15w 16w 17w 21w 22w 23w 24w 25w 26w 27w 28w 0.25≤TSH≤2.5 23 30 31.33 34.33 38.5 57.67 58.04 59.25 62.18 66.17 77 74.8 80.33 2.54治疗 30 35 35.5 57.5 60.8 61 70 78.67 TSH>4未治疗 22 29.5 31 34 54.1 53.87 57.33 59.6 63 69 74.5 标准差0 5.965 2.16 2.398 2.429 4.508 5.063 5.62 4.283 3.061 5.292 8.289 5.431 标准差1 2.517 3.782 2.646 1.732 7.506 6.228 5.348 2.869 1.528 6.652 2.121 2.317 标准差2 5.657 6.364 2.121 3.421 3.606 7.071 4.423 1.155 标准差3 0.707 0.707 6.188 3.564 3.05 4.123 腹径一 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.25≤TSH≤2.5 2.54治疗 TSH>4未治疗 孕周 腹径 13周至28周腹径 腹围一 13w 14w 15w 16w 17w 21w 22w 23w 24w 25w 26w 27w 28w 0.25≤TSH≤2.5 68 77.5 97.67 108.09 116.71 178.67 183.19 193 190.32 209.83 223.67 224.8 243.44 2.54治疗 99 104.67 108.5 176 187.33 193.5 238 238 TSH>4未治疗 70.5 93.5 104.5 109 165.5 170.4 181 185 200 203 230.25 标准差0 6.245 7.503 5.955 9.354 9.656 11.689 23.967 18.246 22.569 6.178 12.662 4.324 15.589 标准差1 6.397 11.194 7.676 4.573 22.502 9.826 15.372 7.931 4.163 15.875 7.778 11.703 标准差2 26.87 5.859 2.121 9.889 11.587 14.849 16.971 17.349 标准差3 0.707 3.536 6.455 10.607 15.188 8.456 11.18 13.937 腹围一 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.25≤TSH≤2.5 2.54治疗 TSH>4未治疗 孕周 腹围 13周至28周腹围 股骨长一 13w 14w 15w 16w 17w 21w 22w 23w 24w 25w 26w 27w 28w 0.25≤TSH≤2.5 10.67 12.17 16.29 19.27 29 38.67 38.85 39.79 43.82 46.33 47 51.8 53.67 2.54治疗 15 20.33 22 37.8 40.4 42 48 52 TSH>4未治疗 9.5 16.5 16.5 20.5 34.9 37.75 39.22 40.8 42 45 50.67 标准差0 0.577 1.329 2.138 2.97 1.272 2.132 2.397 3.12 3.473 2 3.606 0.837 3.5 标准差1 2.062 3.421 1.732 1.472 2.517 2.504 3.104 1.633 2.082 3.304 1.414 3.141 标准差2 2.828 2.517 0.707 3.701 2.108 4.95 7.071 5.033 标准差3 0.707 0.707 1.708 2.828 3.536 2.55 0.894 2.588 2 股骨长一 0 0 0 0 2.138 2.138 3.421 3.421 2.828 2.828 0.707 0.707 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.25≤TSH≤2.5 2.54治疗 TSH>4未治疗 孕周 股骨长 13周至28周股骨长 双顶径二 29w 30w 31w 32w 33w 34w 35w 36w 37w 38w 39w 40w 41w 0.25≤TSH≤2.5 76.2 77.33 81.5 83.93 83.8 84.83 91.33 90.21 92.43 92.56 93.83 94.33 95.8 2.54治疗 75.5 78.29 81 84.75 82.43 86.5 88.47 91 93 92.92 94 94 96.5 TSH>4未治疗 77.67 78.7 81 77.67 83.5 85 87.8 91.92 92.14 91.86 91.83 92.67 标准差0 2.877 3.927 3.349 3.05 2.7 3.806 2.601 3.731 2.697 4.28 2.069 1.906 2.49 标准差1 2.588 3.449 2.734 2.174 3.047 3.43 2.823 2.914 3.039 2.405 2.342 1.85 4.726 标准差2 3.512 3.45 2.236 1.708 6.658 0.707 3.055 1.528 2.828 1.379 2.449 1.414 2.121 标准差3 3.011 3.713 1.732 11.899 4.037 6.557 3.347 2.109 3.132 5.113 3.011 2.082 双顶径二 76.2 75.56 75.5 29w 77.33 77.31 78.29 77.67 81.5 81.14 81 78.7 83.93 83 84.75 81 83.8 78.75 82.43 77.67 84.83 84.21 86.5 83.5 91.33 87.83 88.47 85 90.21 89.33 91 87.8 92.43 91.33 93 91.92 92.56 92.32 92.92 92.14 93.83 92.88 94 91.86 94.33 93.89 94 91.83 95.8 93.33 96.5 92.67 0.25≤TSH≤2.5 2.54治疗 TSH>4未治疗 孕周 双顶径 29周至41周双顶径 胸径二 29w 30w 31w 32w 33w 34w 35w 36w 37w 38w 39w 40w 41w 0.25≤TSH≤2.5 64.33 66.78 72.19 74.64 72.1 75.17 78.71 81 81.15 81.47 81.93 83.17 82 2.54治疗 64.5 67 70.8 73 71 72.5 81.69 79.13 82.29 83.17 81.88 84.4 81.5 TSH>4未治疗 66.83 68.33 70.58 67.25 71.83 75.67 78 80 80.29 80.86 81 79.67 标准差0 2.958 4.577 2.96 3.003 3.665 4.201 3.771 3.771 3.541 4.58 2.586 2.995 4.278 标准差1 3.435 4.059 3.599 3.175 3.367 4.021 4.452 4.452 3.864 3.025 2.781 1.907 3.606 标准差2 3 4.655 3.194 2.363 2.646 3.536 4.726 2.582 2.87 3.129 1 3.209 0.707 标准差3 3.971 3.122 1.732 9.142 2.927 6.028 3.674 5.939 3.147 4.375 3.204 1.528 胸径二 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.25≤TSH≤2.5 2.54治疗 TSH>4未治疗 孕周 胸径 29周至41周胸径 腹径二 29w 30w 31w 32w 33w 34w 35w 36w 37w 38w 39w 40w 41w 0.25≤TSH≤2.5 83.56 82.38 91.14 92.07 94.5 95.64 100.59 103.79 106.05 109.37 110.13 112.89 110.4 2.54治疗 79.25 84.29 88.2 95.75 95.86 96.17 107 101.34 104.14 108.25 109 111.33 119.5 TSH>4未治疗 81 85.33 88.33 84.75 92.17 91.67 99 102.67 106.86 105.57 109.33 110.33 标准差0 4.586 5.284 5.206 4.843 4.625 7.702 4.501 4.682 6.139 5.188 5.438 4.575 2.608 标准差1 6.38 3.32 5.699 3.467 7.988 5.879 4.313 4.423 3.933 6.26 4.619 8.737 标准差2 3.202 2.87 1.924 4.349 5.859 7.778 4.501 5.956 2.854 6.96 7.394 5.675 0.707 标准差3 6.45 6.837 7.506 14.975 8.998 7.638 8.093 4.499 2.795 6.63 3.266 9.074 腹径二 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.25≤TSH≤2.5 2.54治疗 TSH>4未治疗 孕周 腹径 29周至41周腹径 腹围二 29w 30w 31w 32w 33w 34w 35w 36w 37w 38w 39w 40w 41w 0.25≤TSH≤2.5 264.44 265.67 277.23 287.36 296.6 300.79 314.65 327.07 332.68 339.32 342.4 354.33 356.6 2.54治疗 249.5 264.43 269.6 281.25 294.86 301.83 327.33 320.57 334 342.79 343 350.67 373.5 TSH>4未治疗 254.74 272.78 281 268.5 289 297 320.2 320.5 334.57 329.14 341.67 343 标准差0 12.156 38.034 15.449 17.596 13.664 22.168 11.346 14.465 19.074 15.988 17.694 14.025 6.914 标准差1 23.965 12.399 10.111 14.856 19.718 13.992 14.878 13.51 12.728 12.608 16.954 10.899 14.844 标准差2 13.796 7.044 9.555 42.836 11.015 19.799 15.011 14.14 8.287 17.243 18.348 11.777 3.536 标准差3 22.774 18.866 22.539 42.067 16.125 14.731 14.533 18.933 10.454 15.742 8.042 19.925 腹围二 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.25≤TSH≤2.5 2.54治疗 TSH>4未治疗 孕周 腹围 29周至41周腹围 股骨长二 29w 30w 31w 32w 33w 34w 35w 36w 37w 38w 39w 40w 41w 0.25≤TSH≤2.5 55.56 57.23 60.55 61.43 64.4 65.71 67.82 69.93 70.7 72.06 73 74.11 75 2.54治疗 53.25 56.29 59.71 64 61.14 64.67 70.57 71.05 73.43 74 73.75 77.5 TSH>4未治疗 56.67 58.8 60.67 56.25 63 68 69.08 71.83 68.14 72.17 73.67 标准差0 2.789 3.442 2.988 2.138 2.366 4.762 4.762 8.7 2.399 2.616 2.56 2.374 1.581 标准差1 4.506 2.94 2.215 2.29 3.388 2.563 2.146 1.94 1.987 2.182 2.398 2.137 1 标准差2 2.5 1.496 2.168 4.243 2.082 1.414 2.637 2.854 1.946 2.944 1.643 0.707 标准差3 2.066 4.3676 1.155 13.074 2.16 2.739 3.476 0.976 7.647 1.169 1.155 股骨长二 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.25≤TSH≤2.5 2.54治疗 TSH>4未治疗 孕周 股骨长 29周41周股骨长 Chart3 90.21 89.33 91 87.8 全 甲功分组 13w 14w 15w 16w 17w 18w 19w 20w 21w 22w 23w 24w 25w 26w 27w 28w 29w 30w 31w 32w 33w 34w 35w 36w 37w 38w 39w 40w 41w 947522 0 35 948157 0 28 948159 0 40 948237 0 37 948360 0 49 948362 0 52 948366 0 24 948741 0 38 948935 0 24 59 948958 0 33 953977 0 45 954088 0 30 954542 0 21 954661 0 32 954809 0 33 955157 0 31 955513 0 22 955631 0 35 955929 0 36 956117 0 39 956777 0 40 956986 0 25 957001 0 28 957064 0 32 957166 0 38 958162 0 34 958183 0 24 958845 0 34 959113 0 31 965282 0 38 966394 0 40 966467 0 36 966892 0 33 967020 0 25 29 967069 0 36 967072 0 24 I0576727 0 36 955792 0 50 955921 0 56 956849 0 55 948157 0 49 948460 0 50 948487 0 49 949063 0 48 958413 0 49 965865 0 52 966833 0 49 953512 0 50 952690 0 56 954088 0 56 954403 0 52 955490 0 53 954542 0 54 954870 0 55 956118 0 56 954693 0 54 957001 0 53 956959 0 59 956986 0 55 955961 0 58 956902 0 62 956582 0 56 956807 0 60 I0576843 0 51 I0576714 0 58 I0576727 0 59 957498 0 55 948159 0 66 957716 0 59 948936 0 53 967072 0 57 965587 0 53 966530 0 58 965667 0 51 953291 0 56 954661 0 53 954948 0 58 955929 0 60 954809 0 64 956337 0 60 956958 0 54 957166 0 60 956816 0 63 I0576796 0 54 I0576618 0 62 948237 0 64 948410 0 47 948133 0 59 958162 0 55 948603 0 58 958413 0 54 958845 0 59 959113 0 53 959136 0 55 958845 0 59 958183 0 57 967020 0 52 966945 0 61 953359 0 56 954938 0 59 955254 0 60 955157 0 65 954659 0 61 955769 0 53 955057 0 59 957064 0 59 956117 0 59 955254 0 60 947522 0 55 948455 0 50 956706 0 58 948366 0 60 948958 0 62 948741 0 66 958691 0 62 966394 0 55 966546 0 58 965282 0 62 967069 0 63 I0577403 0 62 955631 0 66 955564 0 58 I0576712 0 64 956777 0 66 958162 0 67 958183 0 62 956119 0 73 957143 0 64 958573 0 66 953977 0 73 956849 0 73 957013 0 64 I0576796 0 70 I0576859 0 72 953512 0 70 954693 0 68 I0576714 0 73 956709 0 74 957199 0 72 957196 0 72 948286 0 71 966892 0 73 967096 0 73 956164 0 80 957973 0 78 957232 0 77 957522 0 72 948655 0 71 957714 0 77 965865 0 74 I0577403 0 75 966530 0 76 953512 0 71 953291 0 76 954088 0 82 954403 0 78 954542 0 74 954948 0 80 954870 0 78 955254 0 78 956463 0 74 956118 0 79 954693 0 78 955792 0 79 955769 0 75 955921 0 78 955631 0 82 956337 0 77 956812 0 79 956986 0 76 956639 0 63 955254 0 78 956902 0 78 956582 0 73 956816 0 79 I0576843 0 72 I0576712 0 78 I0576727 0 77 948178 0 75 956943 0 77 948159 0 88 948133 0 79 948387 0 71 948360 0 80 948460 0 72 948487 0 79 948603 0 82 948958 0 77 948936 0 79 948935 0 84 958845 0 78 959113 0 74 958845 0 78 967020 0 77 966546 0 78 967072 0 80 967069 0 81 966833 0 76 952690 0 83 953359 0 81 954014 0 75 956040 0 82 956046 0 83 954893 0 76 954809 0 85 955157 0 83 955057 0 82 956959 0 84 957166 0 83 I0576796 0 77 I0576618 0 89 948157 0 80 956777 0 84 958162 0 77 948362 0 81 958413 0 74 958573 0 81 966394 0 84 966467 0 76 965282 0 85 953512 0 78 954661 0 84 955836 0 86 956958 0 79 957001 0 84 957064 0 76 956117 0 83 955961 0 82 956807 0 86 948237 0 88 957716 0 85 948741 0 84 949063 0 85 966945 0 89 954938 0 80 954948 0 87 957862 0 85 955836 0 86 948133 0 85 958691 0 80 959136 0 84 965587 0 87 965730 0 81 965667 0 83 952131 0 82 955490 0 83 955254 0 84 954659 0 88 955721 0 84 956986 0 86 957024 0 88 955254 0 84 957583 0 87 947522 0 77 948455 0 76 955935 0 87 957716 0 85 I0576859 0 88 953291 0 86 952690 0 88 955929 0 90 955921 0 88 956849 0 90 956959 0 92 955721 0 84 957143 0 84 I0576843 0 85 I0576712 0 91 I0576714 0 90 947522 0 82 948366 0 87 959136 0 88 966892 0 88 965587 0 91 I0577403 0 90 966530 0 92 952131 0 85 953551 0 86 954440 0 90 953977 0 88 954870 0 90 956119 0 94 955792 0 91 955646 0 82 955057 0 93 956812 0 92 957064 0 85 954864 0 88 956582 0 89 I0576796 0 91 I0576618 0 96 I0576727 0 92 948157 0 87 955697 0 82 956943 0 90 948133 0 92 948362 0 87 948487 0 90 948645 0 93 948935 0 96 949046 0 90 959113 0 87 959328 0 81 965888 0 93 966394 0 91 967096 0 91 967072 0 91 966807 0 89 966833 0 86 953512 0 91 953359 0 92 954938 0 89 954948 0 86 954893 0 90 955929 0 94 954809 0 96 956118 0 91 954693 0 83 955157 0 91 955769 0 93 955245 0 90 956337 0 91 956958 0 89 956812 0 91 957166 0 94 956117 0 93 956902 0 92 956816 0 92 956807 0 95 948237 0 93 958162 0 91 I0576859 0 93 948362 0 85 948360 0 93 948460 0 89 948741 0 94 958845 0 93 958691 0 89 959121 0 91 958845 0 93 958183 0 90 957902 0 92 958573 0 91 967020 0 90 966546 0 92 965282 0 95 966945 0 96 967069 0 91 965865 0 93 952131 0 90 953291 0 91 954088 0 98 954403 0 90 955490 0 89 954661 0 90 954938 0 90 954809 0 93 956118 0 89 954693 0 88 957001 0 90 956959 0 92 956986 0 93 957166 0 94 956639 0 72 955961 0 93 956582 0 91 956807 0 95 I0576843 0 90 I0576618 0 97 I0576712 0 95 I0576727 0 95 948157 0 91 948133 0 90 956777 0 95 948360 0 95 948603 0 94 958691 0 88 959092 0 94 957714 0 94 966546 0 92 966467 0 93 967096 0 92 967072 0 90 954014 0 95 954542 0 93 954870 0 94 955254 0 90 955929 0 94 954917 0 956119 0 96 955792 0 94 954659 0 94 955921 0 94 955631 0 95 956940 0 95 956335 0 955254 0 90 956902 0 91 956816 0 94 I0576843 0 92 948237 0 95 948178 0 95 948159 0 100 948366 0 94 948958 0 96 948936 0 94 959136 0 97 958183 0 91 957902 0 95 958573 0 93 967020 0 92 966394 0 94 966892 0 93 965667 0 93 952690 0 91 953701 0 92 954014 0 92 953977 0 93 954870 0 94 955631 0 96 956849 0 96 956902 0 92 957143 0 94 957843 0 98 948936 0 94 958845 0 95 958398 0 94 958845 0 95 957714 0 96 958573 0 91 965865 0 93 965667 0 94 953701 0 93 954542 0 92 957001 0 95 948958 0 95 965865 0 89 944130 1 37 948244 1 31 948352 1 26 948496 1 31 953808 1 37 953944 1 37 954248 1 38 955097 1 30 955208 1 37 955853 1 37 955933 1 32 956903 1 27 957247 1 32 957608 1 27 958089 1 49 958303 1 24 958452 1 34 958589 1 24 958691 1 32 966072 1 35 967232 1 26 I576407 1 60 951613 1 55 949080 1 56 953808 1 55 956735 1 56 956812 1 56 956903 1 58 947733 1 51 948352 1 53 966513 1 54 967232 1 53 953550 1 61 953432 1 56 954248 1 57 944130 1 58 955853 1 62 955097 1 54 955921 1 58 956511 1 49 957608 1 57 957564 1 59 957247 1 60 948244 1 59 957799 1 56 959393 1 58 958589 1 61 958628 1 51 958303 1 57 966072 1 59 953296 1 63 955244 1 60 955140 1 59 955933 1 58 957565 1 63 956634 1 61 956511 1 63 956436 1 60 948558 1 62 I0577340 1 62 955208 1 65 959393 1 62 967232 1 61 953531 1 63 958088 1 63 948496 1 53 958452 1 63 948385 1 67 959230 1 62 954013 1 72 955112 1 70 955715 1 72 957361 1 68 956205 1 72 957609 1 76 951613 1 75 955853 1 80 956735 1 77 948385 1 73 958089 1 76 953550 1 81 953944 1 81 953808 1 79 955933 1 72 955921 1 81 956436 1 76 956903 1 81 948244 1 78 947733 1 76 958322 1 75 948352 1 75 958628 1 71 957539 1 79 953432 1 79 954248 1 80 944130 1 81 957565 1 83 958589 1 85 966513 1 77 966072 1 83 953296 1 79 955208 1 85 955859 1 78 955140 1 81 955097 1 81 956047 1 81 957608 1 82 948496 1 80 949045 1 86 959393 1 85 959230 1 79 958303 1 81 954001 1 83 953531 1 83 956634 1 83 956511 1 85 957564 1 85 957799 1 76 965596 1 82 I576407 1 83 953944 1 86 955244 1 88 953227 1 79 955853 1 88 957799 1 85 951613 1 89 953296 1 88 953432 1 91 955057 1 84 956205 1 86 956436 1 86 955614 1 86 948558 1 86 958452 1 87 958089 1 93 966513 1 86 966072 1 92 I576407 1 88 955140 1 91 953227 1 86 955933 1 86 956735 1 92 957112 1 89 956397 1 96 948244 1 89 958322 1 91 949080 1 91 959393 1 90 958723 1 95 966513 1 91 967232 1 88 954011 1 92 953550 1 93 954248 1 88 953808 1 94 953531 1 91 955208 1 96 953227 1 86 955097 1 92 957565 1 95 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