血清_尿PSA比值对血清PSA处于_灰区_中前列腺癌的诊断价值

·≤∶γ · · · “ ” 【 】 “ ～▲αχα℃ 。 “ ” ” — —— —χα ▲▲ ★’ ≥γ ▲▲∶℃ 。 ℃≤χμ≤ αχα▲ 。 ℃ ℃ 【 】 ℃ ★∶χ≤α ±▲χα’℃ ★γχ—▲ ±≤χ▲≤’℃ ★μχ∶≥ ±αχγ▲ —χ▲μ ±▲χα ℃ αχ…μγ αχ≥αμ —χα 。 ～▲αχα ℃℃ 。∶《 ℃ ±αχ≥’ ℃ —χ▲≥× αχ▲× ▲χ≤—× αχα∶ ±αχγ▲’ ℃ ★≤χ▲≥ ≥≥χ▲《 μχγ《。 The role of the ratio of serum PSA and urine PSA in diagnosing prostate carcinoma within the serum PSA “gray ” zone 1. LI Liao ￣ yuan, GAO Xin. Department of Urology, The Third Affiliated Hospital of SUN Yat ￣sen University, Guangzhou 510630, China.. 2. LI Liao ￣yuan, YANG Ming ,ZHANG Hai ￣bin ,LIN Zhe. Department of Urology, The First People ’s Hospital of Foshan, Foshan 528000, China. 3. LI Jie ￣fang,LUO Zhi ￣gang,CAO You ￣han. Department of Urology,The First Affiliated Hospital of South ￣China University, Heng yang 421000, China. 【Abstract 】 Objective To evaluate the value of serum and urine prostate specific antigen ratio （s/u PSA ）in diagnosing patients with prostate carcinoma （PCa ） whose serum PSA (sPSA) concentration is between 4.0 ng/ml and 10.0ng/ml. Methods A total of 191 consecutive patients with prostate diseases whose sPSA concentration ranged from 4.0 ng/ml to 10.0ng/ml were accessed. The sPSA and uPSA concentration of all patients was analyzed by radioimmunologic assay and the s/u PSA ratios were calculated. According to the results of prostate biopsy, the patients were divided into two groups: PCa group (n=76) and benign prostate hyperplasia (BPH) group (n=115). The receiver operating characteristic (ROC) curves were generated by plotting the sensitivity versus specificity. Area under the cures was calculated for each assay. Results There was no statistically significant difference in both sPSA and uPSA levels between BPH group and PCa group(5.20±1.09ng/ml vs 6.41±2.12ng/ml; 3.57±0.97 ng/ml vs 2.17±0.61 ng/ml respectively )(t=0.91, t=1.24, P>0.05, respectively). However, the s/u PSA ratios in PCa group were higher than those in BPH group (4.13 ±1.09 vs 2.32± 0.61, t =4.17, P <0.01). Area under the ROC curves of s/u PSA ratio and sPSA were 0.836 and 0.703 respectively. The specificity of s/u PSA ratio and sPSA were 77.1% and 39.6% respectively at cutoffs yielding 95% sensitivity. Conclusions At the same sensitivity, s/u PSA has a higher specificity than sPSA. 【Key words 】 Prostate specific antigen; Prostatic neoplasms; Carcinoma The s/u PSA ratio can provide better differential effect of PCa and BPH than traditional sPSA when sPSA concentration ranges from 4.0 ng/ml to 10.0ng/ml. ∶▲αγμα ×∶≤…ααα × —≤▲ααα × ·≤∶≥ · 。° × ≤ × —χα “ ” 。 —χα 、 ℃ ▲ ～▲αχα℃ 。≤α《 、 ～▲αχα℃ 。 。 ★ × ’ 、 ≤αα≤ ≥ ≤αα≥ γ 。 —χα ≤χ —χα℃ ▲αχα℃ 、 ≤ ▲∶ ≤α γα ℃ ≥χ—α ▲∶ ≤α 、 。 、 αχ▲ αχ∶ 。 αχ▲ αχ▲ μ≥ 。 。 χ 、 、 ± ≤ 、 ～▲αχα℃ ▲χ 。 。 、 、 ℃ ≤ ℃ —γα▲α γ 。 ～∶ ▲ 。 ∶▲αα ℃ μχ∶ μ×— ▲∶ μ∶αα ℃ ≤α γα ×▲αα 。 、 ▲▲χα 。 ℃ 、 ° 、℃ 、 。 、 ▲▲∶μ γχ▲ ▲▲∶ γγχ≥ ×× αχα∶ × ℃ ～…≥ γ…χ▲ ≥γ αχα▲ ★ ▲’ 。 ▲ ★℃’ ≥γ ▲▲∶ 、℃ ★ ★℃’ ℃ ±αχγ▲ ≤χ▲≥ μχ∶≥ ±αχ≥ χ± ’ γχ—▲ ±≤χ▲≤ ±▲χα ∶χ≤α ±▲χα —χ▲μ ≤χμ≤ ±αχγ▲ 、 ℃ …∶《 ℃ ∶χ≤μ℃ ∶χα∶ —χμ《 …—χα《 ∶《 ℃ ≤χ▲∶℃ μχ≥ μχγ《 ≥≥χ▲《★ ▲ ≤’ 。 ℃ ▲αα《 ▲ ·≤∶… · ≤ ℃ ★《’ ≥∶χα ℃ ° ★℃’ ★《’ ±★《’ αχ∶ °★《’ γμχ… ° ≥αχα ★《’ ±★《’ γχμμ °★《’ —χμ ∶≥χ— …≥χα ≥≥χ≥ αχ…▲ αχ≥ …∶χ …αχα …∶χα αχα —χ≥▲ ∶χ≤μ μχ≥— ∶—χ▲ —χμ —≥χ▲ αχ—γ αχμ▲ αχ—▲ γμχ∶ γ≤χγ γ≤χ ≥—χ ≥γχ∶ …≤χ∶ ∶χα ∶χα∶ —χμ …∶χα …—χα …—χγ … αχ≥∶ αχ≥μ … ∶χα ▲ααχα ≤χ▲∶ αχ≥— μχγ ▲≤χ▲ αχ≤ ∶≥χ… …γχ∶ μχ≥ ≥≥χ▲ μχ▲α αχγ▲ ≥∶χ≤ …≤ αχμ≥ ∶μχ≤ ▲ααχα αχμ 。 …χ—《 …≥χγ《 αχ≥αμ ▲ 。 。℃ αχ…μγ × ▲ ℃ ★《’ × ★《’ —χα ℃ ≤χ μχ —χα γ 。 ▲χ ∶ 。 、 “ 。 α▲ ≤ ” 。 。 —χα ～▲αχα℃ ～▲αχα℃ —χα℃ ≥ ▲° α▲ ° × ℃ ▲α ℃ 。 ▲▲ α▲ ° α《 。 。 … ∶ ×▲α 。 ～▲α γ α▲ ° “ α≤ ” 。 。 。 、 × ▲≤ ★ ×’ 、 。 ▲μ 、 ·HC] · 。 ℃ ℃ αχα∶ 。 ℃ ℃ 。℃ ℃ ℃ ℃ χ≤ ℃ ▲αα《 —χ▲ …χ—《 …≥χγ《 αχαα∶ χ≤ ≤μχ▲≥ ℃ 。 ℃ 。 。 。 ≥—χ▲ ℃ —χ▲ “ ” “ ” 、 1 2 Lee R, Localio AR, Armstrong K, et al. 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