欧洲理事会(CoE)和ETS123规定

欧洲理事会(CoE)和ETS123规定 欧洲理事会(CoE)和ETS123规定 ?Isolators Theresultcomesinthissentence: NCThesameprinciplesregardingqualityandquantityofspace, Environmentalenrichmentandotherconsiderationsinthis documentshouldapplytocontainmentsystemssuchasindividually ventilatedcages(IVC),althoughthedesignofthesystemmay meanthatthismayhavetobeapproacheddifferently.N) Conclusion: NewfinalversionasdraftofETS123datedDecember2004isgivingexcellentbaseforfurthermoresocialandfairwork withlaboratoryanimals.AnewmeetingofcommissionispreparedforDecember2005anddraftversionshouldbere2 placedtroughthefinalversionofETS1232005.Fromthismoment,allnationalcommissionsofcountriesintheEUare officiallyabletoreplaceoldETS123from1986inthenationallaw. Practically,todayallnewinstallationinEurope,butalsoinotherregionoftheworldareacceptingtodayNvsnotyetrati2 fieddraftofETS123 ?0?P?t???((CoE)??ETS123???? StanisavHerman EHRETLabor&PharmatechnikFabrikstr.279312Emmendingen,Germany TIZBIFO(?d???.?1????IVC??????????????????)???9?????(???:?? FELASA(???????????9?0?P???T?()?????t?????:?? ???? 1997??,?0?P?t???((CoE)?:???????k?d????,?????d???6ETS123????(?0?P1986???&?????????4?? ?????????????????????e?i??????????)??????A?????????Z?9?D8I?????????8?????o????CoE???????n ??????????8s ?O?????r: 3????5?????????]???????????????O?????????.?O?????&???;... ?-???????n?B??(figs.1-7AppendixA,1986)???.?O?????0????(figs.8-12,AppendixA,1986)???? ??????????????????????????????????8s???????????4?????????9?9???????i??8s?????,?????????????? ?x?????N?m?????f?B?????B?&?????v???????n???z???????B?????.?O????. ?d?????????i????A?????????-?????????????Z?B?Z?????k???????????z?&???????????r?r,?6???? ????CodeofPracticeforLaboratoryAnimalBreeders(1995)8s ???c?????z????,?d?????4?????F???????????????????O???????c??????????????8s NC???Z????A???????9?4?0?P?????4???o????????????????????????8I?.?O8I???????????r??8s?6???z ?????????????????I???????????????????4???????q????????,???????????i?K?????????O???????????? ?A?????n,???????????????????????O???????????????.?t????8s?B?????????????a???????s?T???????? ??8s???????????4?:???B?:???????????u?F???????t???????????&??????8sN) 6 8?8? 8?8?CALAS-ICLASInternationalSymposiumonLaboratoryAnimalScience 2 AppendixA(ETS123,1986)???????t?????Z???? ?? ? ? ? ? ? ,?l?t ?, ???????u: NC?-???????4?d???a?,???????&?N,???????K???4?m???????????????????????s????????8s?D?h???? ???????????f?????????(?G???a?-?f?)????????????,?????a?-?f?)???????????4????????????,?????? ?????????????m?K??,?D?v???????????????????f?D?h???????f???h???????B???4???????p??8s???????? ?????????O??????,?????t???????:?????????(??????????8s?4???k?????i???????z?h???????????????? ???-?F,NC?-??????N)?r???-???????8?????????f?-???R?????t??????????,???k?????????0???8???B???? 50%8s ?4?????&??,?????o???8???????????.??,???????Z?????k???-?????z?h?&???h???.??????N) ????-???????? ?????B??: ?5???w?????????????-?????????????????????n ?? ? (IVC) ?: NC?%???????????????n???z?9?m?c???q??,?????????????4???i????8I???????x?????????k?????F???o ???????c???t???????4??????????,???????(???-??????8sN) ????: 2004??12?T????ETS123?????F?????????n,?B?????0?f8I???????8?i???????????????????u?????G ???????z8s5???T???t???????w?????(??,?????t?????????5TS35?z????8s???????v??,?z ?h?0???:?????????(???????n?4?????????????F??????????6????????????TS38s 8?8? ?????????????d???q???(?????????? 20012E12200 198E12 72 ,???4?z?h?0?P????????????????8I???r,?a???f???e???(?????8?B?????????????(?k???8???n???? ??ETS123????8s ?????????R???]???????w???????????????????????q?? ??????8???????8??w????8???????8??:?C??8????2??8???????8??????? ?F???O????????Π,?t?i8?560118 [????]8????]???9?6???(?????N?????N???N?????????????N?????f?????t???m??,?c?y???????S?0?? ?t??????,?????z??8I?]???????B????,???????%,?(????????????????????,?9?????z??8I???????i???5?h ?0?????0????,???????:?B21?f????????NC?5???z??N) (1,2) 8s?5?????4??????????????,?????????R???]???? ???w??,?q?????]?????????????????????????????.8I???????????P??????,?c?????????????]?????????? ???0???????????????????????h???q?????4????8s[????]8??h?4?:????8I??????8I???0?????R9??,???B?t ?:?h?k??,???F???;????(60mgΠkg)1??,?F?;????(45mgΠkg)3??,???;????(30mgΠ kg)3??????????2??,?? ?h???l???P?????N(STZ,streptozotocin),?????????????z??8I?]??8I?]????8I?????N8IC2( IV.GTT)??????????????????????8I???R??8I???]?????????????f???i???]???????? ?R???r?r,?????w?????????????????t??????8s???????:???]???w????????,?????????-?????f,???????? ?-?????????????????????z???N??,?????????????]????????????????????,???t???????????.???????? ??????8s[????]8??4?m?c?;????STZ???h???l7???????R?i,?m?c?u???8?y??????o??????e??ADP?G???? ?T?:?????2,????o??????????i?[???p,?N?:?????N?t?????p8s?c???y????????8I?s?????????4???S?e??,?? ?????]?? (3,4,5) ????8s????????7???R?4????1?T?i??????8I???R??8I???]?????i?[????,???????p1Kg????, NC?h?(???pN)?????[??,?q?h????8I???D8I???????????R??????;?z???-(20-45mmolΠ L)8I?]???-8I???f?z?????? ?-(3-4mmolΠL)?[??????,?c?????N??C2,?]?F?????o????(4-6.3mgΠdl)8Io?12(1-1. 3mgΠdl),??????(1.3mgΠ dl)8I?????i???????????i?[????,???F???;???????????4?????i?5108?x?????]??8s ?????????????E???h??8I???????4?????i2?T????????1mmolΠ L,?c?s?????v?h?z?u??8s?-?????n???9???; ????(30mgΠkg)?i???;????(60mgΠ kg)????,???]???R???r?r??????????????????,???q?u?????h???;?????? ?3??,?O???9STZ???t???2????o?????,???????0?I???0???z??,?z???-?415-25mmolΠ L?o?????I??1?k?T ????8s?c???42?k?T?i???????.?-?????z?????h???N?f???z??,?c?y?????????????????]????????8s?4?m ???????????????????u,???;?????F??3???R?45?T?i?????.?????.??????,???????O???.????????2???? ?e;?c???;???????????v???O???.??(?41??????),?m?x???????]???????????q??,????????1?????]???? ????,?c???;?????????????D?:?B2?????]???w???h?????????q??8s[????]?5?q???(??STZ???????????? ?R,?y?????????.?I???0?z??????,?????N??C2,???c???????????0?? ?]???????w??,?:?w?i???????t?A?????????f?z??????8I?E???h?s8I??????8I?]??8I?]????,?]?????o????8Io?12 ,?0????????2, ?F8I???;???????????:?B?.???0???]???????w??,?????????.???u???????i????1?????]???K?t ???-,???;?????????u????,???s?T?q?????]??????????????????????8s ?O?????4?????;????STZ???h???l?????R?i??????????1?????]?????????w??;???w?????????m???? ????,2?k?T?i???????????]???0??????????,?c???;?????????????????w?????s?????????]?????????? ?q??8s 8?8? 8?8?CALAS-ICLASInternationalSymposiumonLaboratoryAnimalScience 82