不同眼内填充物作为硅油乳化高危因素的作用INTERACTION OF DIFFERENT OCULAR ENDOTAMPONADES AS A RISK FACTOR
FOR SILCONE OlL EMULSIFlCATION
不同眼内填充物作为硅油乳化高危因素的作用
JOACHIM H. DRESP, PHD,* DIRK-HENNING MENZ, PHDt
Purpose: To investigate the influence of other substances used intraoperatively in vitreoret...
INTERACTION OF DIFFERENT OCULAR ENDOTAMPONADES AS A RISK FACTOR
FOR SILCONE OlL EMULSIFlCATION
不同眼内填充物作为硅油乳化高危因素的作用
JOACHIM H. DRESP, PHD,* DIRK-HENNING MENZ, PHDt
Purpose: To investigate the influence of other substances used intraoperatively in vitreoretinal surgery on the emulsification of silicone oil in patients' eyes.
Methods: Gas chromatography coupled mass spectroscopy of the headspace (GelMS/HS) was used to detect volatile compounds in silicone oil samples explanted from patients qualitatively as well as quantitatively. Surface and interfacial tensions of the explanted samples were measured using the pendent drop technique.
Results: Some samples of non -emulsified explanted silicone oil were not different in their content of volatile substances measured by GC-MS/HS. In all explanted samples of emulsified silicone oil volatile substances could be detected, which do not exist or are at the detection limit in native silicone oil for ophthalmic use. The majority of contaminants are
heavy liquids, cleaning substances, and oligosiloxanes.
Conclusion: The contact of silicone oil with all types of substances should be reduced to a minimum. Reuse of tubing sets must be avoided. If a direct exchange between heavy liquids and silicone oil seems necessary, turbulence at the interfaces must be avoided and the contact time between these two endotamponades must be kept as short as possible.If these precautions are obeyed, the risk of emulsification of silicone oil used as an ocular endotamponade can be significantly reduced down to the influence of individual patients' conditions. RETINA 25:902-910, 2005
目的:研究玻璃体视网膜手术中其他眼内填充物对于患者眼中硅油乳化的影响。
方法:用气相色谱质谱的顶空(GelMS/HS)对从患者眼中取出的硅油中的挥发性的物质来进
行定量及定性的检测。用悬滴法测量样品的表面及界面的张力。
结果:根据GC-MS/HS.的测量，取出的没有乳化的硅油样品中其挥发性的物质的含量并没有差异。在所有的取出的乳化硅油样品中可以检测到挥发性的物质。这些挥发物不存在于眼科用硅油中。大多数污染物是重液体、清洁剂和oligosiloxanes 。
结论:硅油应避免和所有类型的其他物质接触。。应避免重复使用管道。如果重液体与硅油发生 了必须的直接混合，应尽量避免接口湍流，其两者的接触时间也应尽量缩短。如果预防措施实行了，那么作为眼内的填充物的硅油发生乳化现象就可以显著降低，甚至只在个别患者发生。
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