姓名 段树民
性别 男
国籍 中国
工作单位、职务:中国科学院神经科学研究所 研究员,副所长;中国科学院院士,神经科
学国家重点实验室主任,全国政协委员
单位电话 021-54921818
传真 021-54921735
电子邮箱 shumin@ion.ac.cn
学历
1978 年 02 月至 1982 年 08 月 蚌埠医学院,医疗系 医学 学士
1982 年 09 月至 1985 年 08 月 南通医学院 生理学 硕士
1988 年 10 月至 1991 年 03 月 日本九州大学医学部 生理学 博士
工作
简历
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1985 年 09 月至 1988 年 09 月 南通医学院航海医学研究所 助教,讲师
1992 年 01 月至 1994 年 02 月 中国科学院上海脑研究所 博士后
1994 年 03 月至 1995 年 03 月 南通医学院航海医学研究所 副研究员,所长
1995 年 04 月至 1996 年 04 月 日本九洲大学医学部 世川医学奖学金特别研究员
1996 年 07 月至 1997 年 11 月 美国夏威夷大学 博士后
1997 年 12 月至 1999 年 12 月 美国加州大学旧金山分校神经科 博士后
2000 年 01 月至今中国科学院神经科学研究所 研究员
2007,9 月:神经科学国家重点实验室 主任
2007 年 11 月 中国科学院 院士
2008 年 3 月 全国政协委员
2008 年 11 月 发展中国家科学院(第三世界科学院, TWAS)院士
2009 年 3 月 中国科学院神经科学研究所 副所长
学术任职
编委: 《Journal of Neurophysiology》, 《Neurobiology of Disease》, 《Glia》,
《Hippocampus》
《中国科学 C 辑:生命科学》
获奖:
2007 年上海市科技精英
2008 年 何梁何利奖
近年发表论文:
Duan S, Anderson CM, Stein BA, Swanson RA, Glutamate induces rapid
upregulation of astrocyte glutamate transport and cell-surface
expression of GLAST. J Neurosci 19:10193-10200 (1999)
Swanson R.A., Duan S., Regulation of glutamate transporter function
(Review). Neuroscientist, 5: 280-282 (1999)
Duan S, Cooke IM, Selective inhibition of transient K+ current by La3+ in crab
peptide-secretory neurons. J Neurophysiol 81:1848-1855 (1999)
Duan S, Cooke IM, Glutamate and GABA activate different receptors and Cl
(-) conductances in crab peptide-secretory neurons. J Neurophysiol 83:
31-37 (2000)
Anderson CM, Norquist BA, Vesce S, Nicholls DG, Soine WH, Duan S, Swanson
RA. Barbiturates induce mitochondrial depolarization and potentiate
excitotoxic neuronal death. J Neurosci. 22:9203-9209.(2002)
Xiang Y, Li Y., Zhang Z., Wang S., Yuan XB., Wu CP, Poo MM and Duan S*,
Nerve growth cones guidance mediated by G-protein-coupled receptors.
Nature Neuroscience, 5, 843 - 848 (2002) (全国百篇优秀博士论文)
Duan, S, C M. Anderson, E C. Keung, K.Farrell, Y. Chen, and RA. Swanson.
P2X7 Receptor-Mediated Release of Excitatory Amino Acids from Astrocytes.
J Neurosci, 23: 1320-1328 (2003)
Yuan X, Jin, M., Xu, X., Wu, CP., Poo, M., and Duan, S*. Signalling and
crosstalk of Rho GTPases in mediating axon guidance. Nature Cell Biology ,
5, 38 - 45 (2003) (全国百篇优秀博士论文)
Wang, Z., Xu, N., Wu,CP., Duan, S*., and Poo, M. Bidirectional Changes
in Spatial Dendritic Integration Accompanying Long-Term Synaptic
Modifications. Neuron, 37: 463-472 (2003)
Yang, Y., Ge, W., Chen, Y., Wu, CP., Poo, M., and Duan, S*. Contribution
of astrocytes to hippocampal long-term potentiation through release of
D-serine. PNAS, 100, 15194 – 15199 (2003) (2003 年中国医药科技十
大新闻)
Zhang, J. Ye, C., Wu, CP., Poo, M., and Duan, S*. ATP Released by Astrocytes
Mediates Glutamatergic Activity-Dependent Heterosynaptic Suppression.
Neuron, 40, 971-982 (2003) Comment in: O Pascual and PG. Haydon,
Synaptic Inhibition Mediated by Glia. Neuron, 40, 873-875 (2003) (全
国百篇优秀博士论文)
Wang B, Xiao Y, Ding BB, Zhang N, Yuan X, Gui L, Qian KX, Duan S, Chen
Z, Rao Y, Geng JG. Induction of tumor angiogenesis by Slit-Robo signaling
and inhibition of cancer growth by blocking Robo activity. Cancer Cell.
4:19-29 (2003).
Li, C., Wu, CP., Duan, S*, and Poo, M. Bidirectional Modification of
Presynaptic Neuronal Excitability Accompanying Spike Timing-Dependent
Synaptic Plasticity. Neuron,41, 257–268 (2004)
Xu, H., Yuan, X., Guan, C., Duan, S., Wu, C., and Feng, L. Calcium signaling
in chemorepellant Slit2-dependent regulation of neuronal migration. PNAS,
101, 4296-4301 (2004)
Pan, P., Cai, Q., Lin, L., Lu, P., Duan, S*., and Sheng, Z.
SNAP-29-mediated Modulation of Synaptic Transmission in Cultured
Hippocampal Neurons. J. Biol.Chem. 280: 25769-25779 (2005)
Xu X, Fu AK, Ip FC, Wu CP, Duan S, Poo MM, Yuan XB, Ip NY. Agrin regulates
growth cone turning of Xenopus spinal motoneurons. Development.
132:4309-4316. (2005)
Jin W, Ge WP, Xu J, Cao M, Peng L, Yung W, Liao D, Duan S, Zhang M, Xia
J. Lipid binding regulates synaptic targeting of PICK1, AMPA receptor
trafficking, and synaptic plasticity. J Neurosci. 2006 Mar
1;26(9):2380-90.
Shen WH, Wu B, Dou Y, Zhang ZJ, Duan S* Rapid activity-induced synaptic
maturation mediated by brain-derived neurotrophic factor. Neuorn, 2006,
50: 401-414(封面文章)
Comment in: Atasoy and Kavalali,Presynaptic Unsilencing: Searching
for a Mechanism. Neuron, 2006, 50:345-346
Ge WP, Yang XJ, Zhang ZJ, Wang HK, Deng QD, and Duan S* Long-Term
Potentiation of Neuron-Glia Synapses Mediated by Ca 2+ -Permeable AMPA
Receptors Science, 2006, 312, 1533-1537 (全国百篇优秀博士论文, 2006
年中国基础研究十大新闻)
Lu W, Zheng BJ, Xu K, Schwarz W, Du L, Wong CK, Chen J, Duan S, Deubel
V, Sun B. Severe acute respiratory syndrome-associated coronavirus 3a
protein forms an ion channel and modulates virus release. PNAS, 2006,
103:12540-12545
Duan S*, Neary J, P2X7/P2Z receptors: properties and relevance to CNS
functions (Invited review). Glia, 2006, 54:738-746.
Ge WP, Duan S*. Persistent Enhancement of Neuron-Glia Signaling Mediated
by Increased Extracellular K+ Accompanying Long-Term Synaptic
Potentiation. J Neurophysiol. 2007, 97: 2564-2569
Yang W, Zheng C, Song Q, Yang X, Qiu S, Liu C, Chen Z, Duan S, Luo J. A
three amino acid tail following the TM4 region of NR2 subunits is
sufficient to overcome er retention of NR1-1a subunit. J Biol Chem. 2007,
282:9269-9278
Zhang X, Xu R, Zhu B, Yang X, Ding X, Duan S, Xu T, Zhuang Y, Han M. Syne-1
and Syne-2 play crucial roles in myonuclear anchorage and motor neuron
innervation. Development. 2007, 134:901-908.
Zhou W, Ge WP, Zeng S, Duan S, Luo Q. Identification and two-photon imaging
of oligodendrocyte in CA1 region of hippocampal slices. Biochem Biophys
Res Commun. 2007 Jan 19;352(3):598-602.
Chen G, Li HM, Chen YR, Gu XS, Duan S* Decreased estradiol release from
astrocytes contributes to the neurodegeneration in a mouse model of
Niemann-Pick disease type C. Glia. 2007, 55:1509-1518.
Wang, C., Zhang, L., Zhou, Y., Zhou, J., Yang, X., Duan, S., Xiong, Z.,
Ding, Y.(2007) Activity-dependent development of callosal projections in
the somatosensory cortex. J. Neurosci. 27: 11334-11342
Z-J Zhang, G Chen, W Zhou, A-H Song, W Wang, T Xu, Q-M Luo, X-S Gu, Duan
S*, Regulated ATP release from lysosomes in astrocytes. Nature Cell Biol
2007, 9: 945-953.
Liao CY, Li XY, Wu B, Duan S*, Jiang GB. Acute enhancement of synaptic
transmission and chronic inhibition of synaptogenesis induced by
perluorooctane sulfonate through mediation of voltage-dependent calcium
channel. Environ Sci Technol. 2008 42:5335-5341
Zheng J, Shen WH, Lu TJ, Zhou Y, Chen Q, Wang Z, Xiang T, Zhu YC, Zhang
C, Duan S, Xiong ZQ. Clathrin-dependent endocytosis is required for
TrkB-dependent Akt-mediated neuronal protection and dendritic growth. J
Biol Chem. 2008,283:13280-13288.
Yu HM, Wen J, Wang R, Shen WH, Duan S, Yang HT. Critical role of type 2
ryanodine receptor in mediating activity-dependent neurogenesis from
embryonic stem cells. Cell Calcium. 2008, 43:417-431.
Li H, Chen G, Zhou B, Duan S*. Actin Filament Assembly by MARCKS- PI(4,5)P2
Signaling Is Critical for Dendrite Branching. Mol Biol Cell. 2008, 19:
4804-4813
Song AH, Wang D, Chen G, Li Y, Luo J, Duan S*, Poo MM. A selective filter
for cytoplasmic transport at the axon initial segment. Cell. 2009,
136:1148-1160.
“*”Corresponding or co-corresponding author.
* 通讯作者
重要国际会议特邀报告:
1. Plenary Lecture: The 9th European Meeting On Glial Cells In Health
and Disease. To be held in 2009, September 8-12, Paris, France
2. 3 rd Annual Canadian Neuroscience Meeting, to be held from May 24-27,
2009, Vancouver, Canada
3. Gordon Research Conference on “ Glial Biology: Functional
Interactions Among Glia & Neurons”, March 15-20, 2009, Ventura, CA
(USA)
4. Gordon Research Conference on “Neurobiology of Brain Disorder ”,
August 24-29, 2008, Oxford, United Kingdom
5. Gordon Research Conference on“Molecular & Cellular Neurobiology ” ,
Jun 8-13, 2008, Hong Kong, China
6. Cold Spring Harbor Laboratory Meeting “Glia in Health & Disease”,
July 17 - 21, 2008, Cold Spring Harbor (USA)
7. Gordon Research Conference on “ Glial Biology: Functional
Interactions Among Glia & Neurons”, March 11-16, 2007, Ventura, CA
(USA)
8. Gordon Research Conference on “ Excitatory Synapses and Brain
Function” , June 10-15, 2007,Colby-Sawyer College in New London, New
Hampshire (USA)
9. 2007 Gordon Research Conference on "Neurotrophic Factors", June 17-22,
2007, Salve Regina University in Newport, Rhode Island
10. Symposium in the 7th IBRO WORLD CONGRESS OF NEUROSCIENCE: Purine
mediated neuron-glia interactions: physiological and pathological
relevance (Chair). Melbourne, Australia, 12-17 July, 2007.
11. Plasticity of neuron-glia signalling, The 4th Congress of Federation
of Asian-Oceanian Neuroscience Societies (FAONS), November 30 -
December 2, 2006, Hong Kong
12. 10.Neuron-glia crosstalking in synaptic plasticity and neuronal
signaling integrations. International symposium on Glial Activities
in Neural Plasticity and Information Processing. Jan 2005, Tokyo
13. Gordon Research Conference (GRC), Glial Biology: Functional
Interactions Among Glia and Neurons, March, 2005, Ventura, CA, USA
14. The 20th BIENNIAL MEETING of the International Society for
Neurochemistry (ISN), Symposium: Glial cells as therapeutic targets
for neurological disorders. Aug 2005, Innsbruck, Austria
15. Contribution of astrocytes to neuronal signaling processing, IBRO
Symposium on Neural Plasticity, Development and Repair, April, 2004,
Hong Kong.
主持重要学术会议:
1. Symposium in 10 th SCBA International Symposium: Development and
plasticity of the Nervous system.(Co-chair) July, 2004, Beijing
2. First Chinese Symposium on Glia functions (Chair), Wuhan, China, Oct
17-18, 2005
3. Gordon Research Conference, Molecular & Cellular Neurobiology.
(Section discussion leader: Synaptic Transmission II). Hong Kong,
June 11-16, 2006
4. Symposium in the 7th IBRO WORLD CONGRESS OF NEUROSCIENCE: Purine
mediated neuron-glia interactions: physiological and pathological
relevance (Chair). Melbourne, Australia, 12-17 July, 2007.
5. Cold Spring Harbor Laboratory Meeting “Glia in Health & Disease”
(Discuss leader), July 17 - 21, 2008, Cold Spring Harbor (USA)